Progress in Azetukalner Development
Xenon Pharmaceuticals has made significant progress in the development of azetukalner, a highly potent and selective Kv7 potassium channel opener, for use in epilepsy and major depressive disorder (MDD). The company is advancing its Phase III epilepsy and MDD programs and expects to initiate the X-NOVA2 trial before the end of the year.
Strong Financial Position
As of September 30, 2024, Xenon reported having $803.3 million in cash and cash equivalents, which is expected to fund operations into 2027, supporting the completion of Phase III studies for azetukalner and other development activities.
Anticipated Key Milestones in 2025
Xenon anticipates pivotal milestones in 2025, including top-line data from the X-TOLE2 epilepsy study in the second half of the year and results from a Phase II MDD study in the first half of the year.
Expansion of Clinical Pipeline
The company is advancing its early-stage pipeline, with plans to file multiple INDs in 2025, including for new Kv7 candidates and Nav1.7 sodium channel inhibitors.