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Knight Therapeutics (TSE:GUD)
TSX:GUD
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Knight Therapeutics (GUD) AI Stock Analysis

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TSE:GUD

Knight Therapeutics

(TSX:GUD)

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Neutral 47 (OpenAI - 4o)
Rating:47Neutral
Price Target:
C$6.00
▼(-0.83% Downside)
Knight Therapeutics faces significant challenges with profitability and cash flow, reflected in its financial performance score. The technical analysis indicates a bearish trend, and the stock appears overvalued with a very high P/E ratio. Despite positive earnings call insights, these factors weigh heavily on the overall score.
Positive Factors
Revenue Growth
The significant revenue growth highlights the company's successful product integration and market expansion, indicating strong future potential.
Product Pipeline Expansion
Expanding the product pipeline and launching new drugs enhances market position and addresses unmet medical needs, supporting long-term growth.
Financial Flexibility
Increased credit facility provides financial flexibility, enabling strategic investments and acquisitions to drive growth and operational resilience.
Negative Factors
Regulatory Challenges
Regulatory setbacks could delay product launches and revenue generation, impacting the company's ability to capitalize on market opportunities.
Profitability Concerns
Weak profitability metrics suggest operational inefficiencies and pressure on margins, which could hinder long-term financial performance.
Cash Flow Issues
Declining cash flow generation limits the company's ability to reinvest in growth initiatives and manage financial obligations effectively.

Knight Therapeutics (GUD) vs. iShares MSCI Canada ETF (EWC)

Knight Therapeutics Business Overview & Revenue Model

Company DescriptionKnight Therapeutics Inc., a specialty pharmaceutical company, develops, acquires, in-licenses, out-licenses, markets, and distributes pharmaceutical and consumer health products, and medical devices in Canada, Latin America, and internationally. It offers Nerlynx for extended adjuvant breast cancer and metastatic breast cancer; Tafasitamab for relapsed or refractory diffuse large B-cell lymphoma; Pemigatinib to treat metastatic cholangiocarcinoma; Trelstar for advanced prostate cancer and for pain associated with endometriosis; Vidaza for myelodysplastic syndrome; Abraxane for metastatic pancreatic adenocarcinoma; Halaven for metastatic breast cancer and doft tissue sarcoma; and Lenvima for differentiated thyroid cancer, advanced renal cell cancer, and unresectable hepatocellular carcinoma. The company also provides Ladevina for multiple myeloma, myelodysplastic syndrome, mantle cell lymphoma, and follicular lymphoma; Zyvalix for metastatic prostate cancer; Karfib for relapsed or refractory multiple myeloma; Leprid for advanced prostate cancer; Rembre for chronic myeloid leukemia; Ambisome and Cresemba for fungal infection; Impavido for leishmaniasis; Exelon for mild to moderately severe dementia; and Ibsrela for the treatment of irritable bowel syndrome with constipation. In addition, it offers Salofalk for ulcerative colitis; Ursofalk to treat biliary cirrhosis; Imvexxy for moderate to severe dyspareunia; Bijuva for moderate to severe vasomotor symptoms associated with menopause in women with intact uteri; Fibridoner to treat idiopathic pulmonary fibrosis; Toliscrin DPI for pseudomonas aeruginosa lung infection in patients with cystic fibrosis; Toliscrin 1-2 for severe acute or resistant chronic infections; and Tobradosa Haler for chronic lung infections. Further, the company finances other life science companies; and invests in life sciences venture capital funds. Knight Therapeutics Inc. was incorporated in 2013 and is headquartered in Montreal, Canada.
How the Company Makes MoneyKnight Therapeutics generates revenue primarily through the commercialization of its pharmaceutical products, which includes both proprietary drugs and licensed products. The company's revenue model is based on sales of these products in the markets where they are available. Key revenue streams include direct sales to healthcare providers and pharmacies, as well as potential royalties and milestones from partnerships with other pharmaceutical companies. Significant partnerships with other biopharmaceutical firms enhance its product pipeline and market reach, contributing to the company's earnings. Additionally, Knight Therapeutics may also engage in licensing deals that provide upfront payments and ongoing royalties, further diversifying its revenue sources.

Knight Therapeutics Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 19, 2026
Earnings Call Sentiment Positive
Knight Therapeutics reported strong financial performance with record revenues and EBITDA, significant growth driven by key products, and an improved financial outlook for 2025. The expansion of the oncology portfolio and increased credit facility provide a solid foundation for future growth. However, challenges were noted with regulatory setbacks in Brazil and Canada and a financial asset loss, though these do not overshadow the overall positive trends and achievements.
Q3-2025 Updates
Positive Updates
Record High Adjusted Revenues and EBITDA
Knight Therapeutics achieved record high adjusted revenues of $319 million and adjusted EBITDA of approximately $49 million for the nine months ended September 30, 2025. Revenues grew by $48 million or 18% compared to the same period last year.
Revenue Growth from Key Products
Revenues were driven by the Paladin and Sumitomo transactions, which contributed $27 million of incremental revenues, and key promoted products delivered organic growth of 12% on a constant currency basis.
Expansion of Oncology Portfolio
Knight expanded its partnership with Incyte by in-licensing the LatAm rights to two innovative drugs, retifanlimab and axatilimab, and launched several products including JORNAY PM in Canada, MINJUVI in Argentina, and PEMAZYRE in Brazil and Mexico.
Increased Financial Outlook for 2025
Knight increased its financial outlook for fiscal 2025, expecting revenues between $430 million and $440 million, and an adjusted EBITDA between 13.5% to 14.5% of revenues.
Increased Credit Facility
Knight doubled its revolving credit facility from USD 50 million to USD 100 million, with an accordion feature for another USD 100 million, providing increased financial flexibility.
Negative Updates
Rejection of Marketing Authorization in Brazil
Knight received a rejection of its marketing authorization application for TAVALISSE from Anvisa, the Brazilian Health Agency. An appeal has been submitted, which could take up to 14 months.
Notice of Noncompliance from Health Canada
Knight received a notice of noncompliance from Health Canada on the drug submission for Qelbree, requiring additional information to be submitted in 2026.
Financial Asset Loss
Knight recorded a net loss of $4.6 million driven by the mark-to-market revaluations of strategic fund investments.
Company Guidance
In the third quarter of 2025, Knight Therapeutics reported record adjusted revenues of $122.6 million, marking a 34% increase over the same period last year, with a constant currency revenue growth of 31%. The company achieved an adjusted EBITDA of $21 million, a 56% rise from the previous year, and an adjusted EBITDA per share increase of 62% to $0.21. This growth was driven by the Paladin and Sumitomo transactions, which contributed $25 million in incremental revenues, and a 15% increase in key oncology products like AKYNZEO and MINJUVI. The company also saw a 127% increase in revenues within its specialty therapeutic area, largely due to the Paladin and Sumitomo portfolios. Despite setbacks with regulatory approvals in Brazil and Canada, Knight aims to address these and has raised its 2025 revenue guidance to between $430 million and $440 million, with an adjusted EBITDA margin of 13.5% to 14.5%.

Knight Therapeutics Financial Statement Overview

Summary
Knight Therapeutics shows stable revenue growth and a strong balance sheet with low leverage. However, profitability and cash flow generation are areas of concern, with declining margins and negative free cash flow growth. Improvements in operational efficiency and cash management are needed.
Income Statement
55
Neutral
Knight Therapeutics shows moderate revenue growth with a TTM increase of 3.16%. However, profitability is a concern, as indicated by a low net profit margin of 0.10% and negative EBIT margin. The gross profit margin remains stable at around 43%, but the declining EBITDA margin suggests pressure on operational efficiency.
Balance Sheet
70
Positive
The company maintains a strong balance sheet with a low debt-to-equity ratio of 0.14, indicating conservative leverage. However, the return on equity is minimal at 0.05%, reflecting limited profitability. The equity ratio is robust, suggesting financial stability.
Cash Flow
45
Neutral
Cash flow performance is weak, with a significant decline in free cash flow growth by 89.84% TTM. The operating cash flow to net income ratio is low at 0.20, indicating challenges in converting income into cash. The negative free cash flow to net income ratio further highlights cash flow issues.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue384.56M371.30M328.20M293.56M243.48M199.52M
Gross Profit165.07M174.41M152.65M138.06M115.41M81.69M
EBITDA52.05M64.38M40.90M25.26M42.59M67.56M
Net Income383.00K4.33M-16.84M-29.89M15.68M31.76M
Balance Sheet
Total Assets1.04B963.80M945.49M1.05B991.89M1.04B
Cash, Cash Equivalents and Short-Term Investments116.42M172.84M154.42M185.61M162.99M411.34M
Total Debt104.74M49.46M69.09M77.70M40.96M56.19M
Total Liabilities274.89M168.69M198.62M228.98M149.87M153.44M
Stockholders Equity763.06M795.11M746.87M825.86M842.02M886.24M
Cash Flow
Free Cash Flow-1.54M4.81M25.98M14.66M-179.56M-32.87M
Operating Cash Flow30.41M36.28M35.94M40.48M44.62M-12.21M
Investing Cash Flow-39.59M16.96M29.34M-63.08M-105.28M101.35M
Financing Cash Flow26.83M-33.54M-81.00M1.76M-78.31M-29.23M

Knight Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price6.05
Price Trends
50DMA
6.04
Positive
100DMA
6.09
Negative
200DMA
5.95
Positive
Market Momentum
MACD
-0.01
Negative
RSI
60.11
Neutral
STOCH
68.95
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TSE:GUD, the sentiment is Positive. The current price of 6.05 is above the 20-day moving average (MA) of 5.84, above the 50-day MA of 6.04, and above the 200-day MA of 5.95, indicating a bullish trend. The MACD of -0.01 indicates Negative momentum. The RSI at 60.11 is Neutral, neither overbought nor oversold. The STOCH value of 68.95 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for TSE:GUD.

Knight Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
76
Outperform
C$126.23M15.1222.62%1.78%16.82%19.25%
71
Outperform
$375.57M22.4012.25%121.40%-47.34%
61
Neutral
5.24%-7.99%
58
Neutral
C$86.45M64.481.88%0.03%-17.30%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
C$169.51M-8.20-20.58%-1.42%35.15%
47
Neutral
$578.13M1,705.88-0.48%18.70%88.31%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
TSE:GUD
Knight Therapeutics
6.05
0.79
15.02%
TSE:TH
Theratechnologies
4.47
2.69
151.12%
TSE:CPH
Cipher Pharmaceuticals
13.48
-0.40
-2.88%
TSE:MDP
Medexus Pharmaceuticals Inc
2.68
0.51
23.50%
TSE:RX
Biosyent
10.97
<0.01
0.09%
TSE:HLS
HLS Therapeutics Inc
5.32
1.67
45.75%

Knight Therapeutics Corporate Events

Knight Therapeutics Reports Record Q3 Revenues and Raises Guidance
Nov 7, 2025

Knight Therapeutics Inc., a specialty pharmaceutical company based in Montreal, focuses on acquiring, in-licensing, and commercializing pharmaceutical products across Canada and Latin America. The company recently reported its financial results for the third quarter of 2025, highlighting record-high quarterly revenues and adjusted EBITDA since its inception. Knight Therapeutics also increased its financial guidance for the year, reflecting strong performance and strategic growth initiatives.

Business Operations and StrategyFinancial Disclosures
Knight Therapeutics Achieves Record-High Revenues in Q3 2025
Positive
Nov 6, 2025

Knight Therapeutics reported record-high quarterly revenues and adjusted EBITDA for the third quarter of 2025, driven by the integration of the Paladin and Sumitomo portfolios and growth in its promoted products. Despite a net loss, the company increased its financial guidance for 2025 and expanded its product pipeline with new launches in Canada, Argentina, Brazil, and Mexico, which could enhance its market positioning and stakeholder value.

The most recent analyst rating on (TSE:GUD) stock is a Hold with a C$6.00 price target. To see the full list of analyst forecasts on Knight Therapeutics stock, see the TSE:GUD Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Knight Therapeutics Secures US$100 Million Credit Facility to Boost Growth
Positive
Oct 31, 2025

Knight Therapeutics Inc. has successfully closed a US$100 million revolving credit facility, doubling its previous capacity and including an accordion feature for an additional US$100 million. This facility, syndicated with four banks including National Bank of Canada, Citibank, CIBC, and TD, is intended to support the company’s growth strategy, including acquisitions, and provides financial flexibility for corporate purposes. The facility has a maturity date of June 17, 2028, with options for extension, and includes various financial covenants.

The most recent analyst rating on (TSE:GUD) stock is a Hold with a C$6.00 price target. To see the full list of analyst forecasts on Knight Therapeutics stock, see the TSE:GUD Stock Forecast page.

Knight Therapeutics’ Earnings Call Highlights Growth and Expansion
Aug 13, 2025

Knight Therapeutics’ recent earnings call revealed a generally positive sentiment, underscored by strong revenue growth and strategic portfolio expansion. Despite facing challenges such as increased operational expenses and a decline in gross margin, the company showcased successful business development and an optimistic revenue outlook, which contributed to the overall positive tone of the call.

Knight Therapeutics Reports Record Revenue Amid Net Loss
Aug 8, 2025

Knight Therapeutics Inc., headquartered in Montreal, Canada, is a specialty pharmaceutical company focused on acquiring, in-licensing, and commercializing pharmaceutical products for Canada and Latin America. The company operates through its subsidiaries United Medical, Biotoscana Farma, and Laboratorio LKM. Knight Therapeutics Inc.’s shares trade on the Toronto Stock Exchange under the symbol GUD.

Business Operations and StrategyFinancial DisclosuresPrivate Placements and Financing
Knight Therapeutics Achieves Record Revenues Amid Strategic Expansions
Neutral
Aug 7, 2025

Knight Therapeutics reported record-high quarterly revenues for the second quarter of 2025, with a 12% increase over the previous year. Despite the revenue growth, the company faced a net loss of $12,622, attributed to hyperinflation accounting in Argentina affecting gross margins. The company entered into a revolving credit facility with National Bank of Canada and executed an asset purchase agreement with Paladin Pharma Inc., indicating strategic moves to strengthen its market position.

The most recent analyst rating on (TSE:GUD) stock is a Buy with a C$7.00 price target. To see the full list of analyst forecasts on Knight Therapeutics stock, see the TSE:GUD Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 07, 2025