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Knight Therapeutics (TSE:GUD)
TSX:GUD

Knight Therapeutics (GUD) AI Stock Analysis

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TSE:GUD

Knight Therapeutics

(TSX:GUD)

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Neutral 57 (OpenAI - 4o)
Rating:57Neutral
Price Target:
C$6.00
▲(0.50% Upside)
Knight Therapeutics' overall score is driven by strong earnings call performance, showcasing significant revenue and EBITDA growth. However, challenges in profitability, cash flow, and valuation metrics weigh down the score. The technical analysis indicates a neutral market sentiment.
Positive Factors
Revenue Growth
The significant revenue growth of 34% year-over-year indicates strong market demand and successful product expansion, supporting long-term business sustainability.
Oncology Portfolio Expansion
Expanding the oncology portfolio with new in-licensed drugs enhances Knight's competitive position in the high-growth oncology market, driving future revenue potential.
Increased Financial Flexibility
Increasing the credit facility provides Knight with greater financial flexibility to invest in growth opportunities and manage operational needs, strengthening its financial position.
Negative Factors
Profitability Challenges
Persistent profitability issues, such as negative net income, could hinder long-term financial health and limit reinvestment capabilities, impacting growth prospects.
Regulatory Setbacks
Regulatory setbacks, like the rejection in Brazil, delay market entry and revenue generation, potentially affecting the company's strategic growth plans in key markets.
Cash Flow Concerns
Weak cash flow performance limits Knight's ability to fund operations and invest in growth, posing risks to long-term financial stability and operational efficiency.

Knight Therapeutics (GUD) vs. iShares MSCI Canada ETF (EWC)

Knight Therapeutics Business Overview & Revenue Model

Company DescriptionKnight Therapeutics Inc., a specialty pharmaceutical company, develops, acquires, in-licenses, out-licenses, markets, and distributes pharmaceutical and consumer health products, and medical devices in Canada, Latin America, and internationally. It offers Nerlynx for extended adjuvant breast cancer and metastatic breast cancer; Tafasitamab for relapsed or refractory diffuse large B-cell lymphoma; Pemigatinib to treat metastatic cholangiocarcinoma; Trelstar for advanced prostate cancer and for pain associated with endometriosis; Vidaza for myelodysplastic syndrome; Abraxane for metastatic pancreatic adenocarcinoma; Halaven for metastatic breast cancer and doft tissue sarcoma; and Lenvima for differentiated thyroid cancer, advanced renal cell cancer, and unresectable hepatocellular carcinoma. The company also provides Ladevina for multiple myeloma, myelodysplastic syndrome, mantle cell lymphoma, and follicular lymphoma; Zyvalix for metastatic prostate cancer; Karfib for relapsed or refractory multiple myeloma; Leprid for advanced prostate cancer; Rembre for chronic myeloid leukemia; Ambisome and Cresemba for fungal infection; Impavido for leishmaniasis; Exelon for mild to moderately severe dementia; and Ibsrela for the treatment of irritable bowel syndrome with constipation. In addition, it offers Salofalk for ulcerative colitis; Ursofalk to treat biliary cirrhosis; Imvexxy for moderate to severe dyspareunia; Bijuva for moderate to severe vasomotor symptoms associated with menopause in women with intact uteri; Fibridoner to treat idiopathic pulmonary fibrosis; Toliscrin DPI for pseudomonas aeruginosa lung infection in patients with cystic fibrosis; Toliscrin 1-2 for severe acute or resistant chronic infections; and Tobradosa Haler for chronic lung infections. Further, the company finances other life science companies; and invests in life sciences venture capital funds. Knight Therapeutics Inc. was incorporated in 2013 and is headquartered in Montreal, Canada.
How the Company Makes MoneyKnight Therapeutics generates revenue primarily through the commercialization and sales of its pharmaceutical products. The company employs a revenue model that includes both direct sales and partnerships with other pharmaceutical companies for product distribution and licensing agreements. Key revenue streams consist of product sales in Canada, royalties from licensed products, and milestone payments from collaborative agreements. Additionally, Knight Therapeutics has established strategic partnerships that enhance its market access and product offerings, contributing significantly to its revenue growth. The company also focuses on acquiring rights to promising pharmaceuticals, which can lead to potential earnings through market exclusivity and pricing strategies in the therapeutic sectors it operates within.

Knight Therapeutics Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 19, 2026
Earnings Call Sentiment Positive
Knight Therapeutics reported strong financial performance with record revenues and EBITDA, significant growth driven by key products, and an improved financial outlook for 2025. The expansion of the oncology portfolio and increased credit facility provide a solid foundation for future growth. However, challenges were noted with regulatory setbacks in Brazil and Canada and a financial asset loss, though these do not overshadow the overall positive trends and achievements.
Q3-2025 Updates
Positive Updates
Record High Adjusted Revenues and EBITDA
Knight Therapeutics achieved record high adjusted revenues of $319 million and adjusted EBITDA of approximately $49 million for the nine months ended September 30, 2025. Revenues grew by $48 million or 18% compared to the same period last year.
Revenue Growth from Key Products
Revenues were driven by the Paladin and Sumitomo transactions, which contributed $27 million of incremental revenues, and key promoted products delivered organic growth of 12% on a constant currency basis.
Expansion of Oncology Portfolio
Knight expanded its partnership with Incyte by in-licensing the LatAm rights to two innovative drugs, retifanlimab and axatilimab, and launched several products including JORNAY PM in Canada, MINJUVI in Argentina, and PEMAZYRE in Brazil and Mexico.
Increased Financial Outlook for 2025
Knight increased its financial outlook for fiscal 2025, expecting revenues between $430 million and $440 million, and an adjusted EBITDA between 13.5% to 14.5% of revenues.
Increased Credit Facility
Knight doubled its revolving credit facility from USD 50 million to USD 100 million, with an accordion feature for another USD 100 million, providing increased financial flexibility.
Negative Updates
Rejection of Marketing Authorization in Brazil
Knight received a rejection of its marketing authorization application for TAVALISSE from Anvisa, the Brazilian Health Agency. An appeal has been submitted, which could take up to 14 months.
Notice of Noncompliance from Health Canada
Knight received a notice of noncompliance from Health Canada on the drug submission for Qelbree, requiring additional information to be submitted in 2026.
Financial Asset Loss
Knight recorded a net loss of $4.6 million driven by the mark-to-market revaluations of strategic fund investments.
Company Guidance
In the third quarter of 2025, Knight Therapeutics reported record adjusted revenues of $122.6 million, marking a 34% increase over the same period last year, with a constant currency revenue growth of 31%. The company achieved an adjusted EBITDA of $21 million, a 56% rise from the previous year, and an adjusted EBITDA per share increase of 62% to $0.21. This growth was driven by the Paladin and Sumitomo transactions, which contributed $25 million in incremental revenues, and a 15% increase in key oncology products like AKYNZEO and MINJUVI. The company also saw a 127% increase in revenues within its specialty therapeutic area, largely due to the Paladin and Sumitomo portfolios. Despite setbacks with regulatory approvals in Brazil and Canada, Knight aims to address these and has raised its 2025 revenue guidance to between $430 million and $440 million, with an adjusted EBITDA margin of 13.5% to 14.5%.

Knight Therapeutics Financial Statement Overview

Summary
Knight Therapeutics shows moderate revenue growth and a strong balance sheet with low leverage. However, profitability and cash flow generation are areas of concern, with declining margins and negative free cash flow growth. The company needs to improve operational efficiency and cash management to enhance financial performance.
Income Statement
55
Neutral
Knight Therapeutics shows moderate revenue growth with a TTM increase of 3.16%. However, profitability is a concern, as indicated by a low net profit margin of 0.10% and negative EBIT margin. The gross profit margin remains stable at around 43%, but the declining EBITDA margin suggests pressure on operational efficiency.
Balance Sheet
70
Positive
The company maintains a strong balance sheet with a low debt-to-equity ratio of 0.14, indicating conservative leverage. However, the return on equity is minimal at 0.05%, reflecting limited profitability. The equity ratio is robust, suggesting financial stability.
Cash Flow
45
Neutral
Cash flow performance is weak, with a significant decline in free cash flow growth by 89.84% TTM. The operating cash flow to net income ratio is low at 0.20, indicating challenges in converting income into cash. The negative free cash flow to net income ratio further highlights cash flow issues.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue413.85M371.30M328.20M293.56M243.48M199.52M
Gross Profit160.41M174.41M152.65M138.06M115.41M81.69M
EBITDA54.35M64.38M40.90M25.26M42.59M67.56M
Net Income-3.49M4.33M-16.84M-29.89M15.68M31.76M
Balance Sheet
Total Assets1.05B963.80M945.49M1.05B991.89M1.04B
Cash, Cash Equivalents and Short-Term Investments95.56M172.84M154.42M185.61M162.99M411.34M
Total Debt106.24M49.46M69.09M77.70M40.96M56.19M
Total Liabilities281.78M168.69M198.62M228.98M149.87M153.44M
Stockholders Equity766.79M795.11M746.87M825.86M842.02M886.24M
Cash Flow
Free Cash Flow5.63M4.81M25.98M14.66M-179.56M-32.87M
Operating Cash Flow35.95M36.28M35.94M40.48M44.62M-12.21M
Investing Cash Flow-53.94M16.96M29.34M-63.08M-105.28M101.35M
Financing Cash Flow25.88M-33.54M-81.00M1.76M-78.31M-29.23M

Knight Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price5.97
Price Trends
50DMA
5.99
Negative
100DMA
6.10
Negative
200DMA
6.03
Negative
Market Momentum
MACD
>-0.01
Positive
RSI
44.93
Neutral
STOCH
29.25
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TSE:GUD, the sentiment is Negative. The current price of 5.97 is below the 20-day moving average (MA) of 6.03, below the 50-day MA of 5.99, and below the 200-day MA of 6.03, indicating a bearish trend. The MACD of >-0.01 indicates Positive momentum. The RSI at 44.93 is Neutral, neither overbought nor oversold. The STOCH value of 29.25 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for TSE:GUD.

Knight Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
74
Outperform
C$383.08M16.0016.32%94.28%5.23%
67
Neutral
C$1.44B28.683.34%22.20%
57
Neutral
$592.59M-168.17-0.48%18.70%88.31%
54
Neutral
C$325.36M-11.87-7.93%62.15%60.50%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
C$149.80M-7.67-20.49%0.73%33.51%
49
Neutral
C$355.53M-6.09-10.76%23.87%-19.57%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
TSE:GUD
Knight Therapeutics
5.97
0.63
11.80%
TSE:CPH
Cipher Pharmaceuticals
15.10
0.73
5.08%
TSE:OGI
OrganiGram Holdings
2.41
0.08
3.43%
TSE:ACB
Aurora Cannabis
6.27
0.06
0.97%
TSE:CRON
Cronos Group
3.76
0.92
32.39%
TSE:HLS
HLS Therapeutics Inc
4.79
0.83
20.96%

Knight Therapeutics Corporate Events

Business Operations and StrategyFinancial Disclosures
Knight Therapeutics Achieves Record-High Revenues in Q3 2025
Positive
Nov 6, 2025

Knight Therapeutics reported record-high quarterly revenues and adjusted EBITDA for the third quarter of 2025, driven by the integration of the Paladin and Sumitomo portfolios and growth in its promoted products. Despite a net loss, the company increased its financial guidance for 2025 and expanded its product pipeline with new launches in Canada, Argentina, Brazil, and Mexico, which could enhance its market positioning and stakeholder value.

Private Placements and FinancingBusiness Operations and Strategy
Knight Therapeutics Secures US$100 Million Credit Facility to Boost Growth
Positive
Oct 31, 2025

Knight Therapeutics Inc. has successfully closed a US$100 million revolving credit facility, doubling its previous capacity and including an accordion feature for an additional US$100 million. This facility, syndicated with four banks including National Bank of Canada, Citibank, CIBC, and TD, is intended to support the company’s growth strategy, including acquisitions, and provides financial flexibility for corporate purposes. The facility has a maturity date of June 17, 2028, with options for extension, and includes various financial covenants.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 11, 2025