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Tonix Pharmaceuticals (TNXP)
NASDAQ:TNXP

Tonix Pharma (TNXP) AI Stock Analysis

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TNXP

Tonix Pharma

(NASDAQ:TNXP)

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Neutral 43 (OpenAI - 5.2)
Rating:43Neutral
Price Target:
$15.50
▲(2.79% Upside)
The score is held down primarily by weak financial performance (losses and cash burn) and bearish technicals (below major moving averages with negative MACD). Positive corporate developments (commercial launch and regulatory/pipeline progress) provide support but do not fully offset the current profitability and trend risks; valuation is difficult to assess due to negative earnings.
Positive Factors
Pipeline Progress
The FDA clearance for TNX-102 SL in major depressive disorder allows Tonix to advance its clinical trials, potentially enhancing its market position by addressing unmet needs in MDD treatment.
New Product Launch
The launch of TONMYA tablets in the U.S. marks a significant step for Tonix, potentially increasing its market presence and offering new treatment options, thereby positively impacting revenue growth.
Strategic Licensing
Acquiring rights to TNX-4900 enhances Tonix's portfolio with a promising non-opioid pain management solution, potentially positioning the company as a leader in this growing market segment.
Negative Factors
Profitability Challenges
Tonix faces significant profitability issues with negative net and EBIT margins, which could hinder its ability to generate sustainable profits and affect its long-term financial health.
Cash Burn
Ongoing cash burn due to negative operating cash flow indicates financial strain, potentially limiting Tonix's ability to invest in growth opportunities and maintain operations without external funding.
Potential Dilution Risk
The increased share offering capacity introduces potential dilution risk, which could negatively impact existing shareholders and reflect a reliance on equity financing to support operations.

Tonix Pharma (TNXP) vs. SPDR S&P 500 ETF (SPY)

Tonix Pharma Business Overview & Revenue Model

Company DescriptionTonix Pharmaceuticals Holding Corp., a clinical-stage biopharmaceutical company, focuses on discovering, acquiring, developing, and licensing therapeutics and diagnostics to treat and prevent human disease and alleviate suffering. Its portfolio includes immunology, rare disease, infectious disease, and central nervous system (CNS) product candidates. The company's immunology portfolio includes biologics to address organ transplant rejection, autoimmunity, and cancer, including TNX-1500, a humanized monoclonal antibody targeting CD40-ligand being developed for the prevention of allograft and xenograft rejection and for the treatment of autoimmune diseases. Its rare disease portfolio comprises TNX-2900 for the treatment of Prader-Willi syndrome. The company's infectious disease pipeline includes TNX-801, a vaccine to prevent smallpox and monkeypox; TNX-1840 and TNX-1850 that are live virus vaccines based on its recombinant pox vaccine (RPV) platform for COVID-19; TNX-3500, a small molecule antiviral drug to treat acute COVID-19; and TNX-102 SL, a small molecule drug to treat Long COVID, a chronic post-acute COVID-19 condition. Its CNS portfolio includes small molecules and biologics to treat pain, neurologic, psychiatric, and addiction conditions, including TNX-102 SL, which is in mid-Phase 3 development for the management of fibromyalgia; TNX-1900 that is in development for the prevention of migraine headache; and TNX-1300, a biologic designed to treat cocaine intoxication. The company was founded in 2007 and is headquartered in Chatham, New Jersey.
How the Company Makes MoneyTonix Pharmaceuticals generates revenue primarily through the development and commercialization of its product candidates. The company may receive funding through government grants, collaborations, and partnerships with larger pharmaceutical companies or research institutions. Additionally, Tonix may generate revenue from licensing agreements or royalties if its products are successfully developed and brought to market. The company is actively seeking strategic partnerships to enhance its research capabilities and accelerate the development of its product pipeline, which can contribute to future earnings.

Tonix Pharma Financial Statement Overview

Summary
Tonix Pharma shows revenue growth but struggles with profitability and cash flow. The company has a strong equity position with minimal leverage, but negative return on equity and cash flow issues highlight ongoing financial challenges.
Income Statement
Tonix Pharma has shown some revenue growth with a 4.76% increase in the TTM period. However, the company is struggling with profitability, as evidenced by negative net profit margins (-5.41%) and EBIT margins (-8.28%). The gross profit margin is relatively low at 29.27%, indicating challenges in cost management. Overall, while there is some revenue growth, the company faces significant profitability issues.
Balance Sheet
The balance sheet shows a strong equity position with a low debt-to-equity ratio of 0.0029, indicating minimal leverage. However, the return on equity is negative (-37.82%), reflecting ongoing losses. The equity ratio is not explicitly calculated, but the high stockholders' equity relative to total assets suggests a solid equity base. Despite the strong equity position, the negative ROE highlights profitability challenges.
Cash Flow
Tonix Pharma's cash flow statement reveals a negative operating cash flow, indicating cash burn. The free cash flow growth rate is positive at 16.22%, suggesting some improvement. However, the operating cash flow to net income ratio is negative, and the free cash flow to net income ratio is slightly above 1, indicating that cash flow is not significantly worse than net income. Overall, cash flow remains a concern despite some positive growth.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue10.30M10.09M7.77M0.000.000.00
Gross Profit3.53M2.33M3.03M0.000.00-27.00K
EBITDA-97.31M-74.32M-114.09M-110.84M-92.26M-50.44M
Net Income-99.22M-130.04M-116.66M-110.22M-92.29M-50.46M
Balance Sheet
Total Assets252.44M162.89M154.46M225.69M240.90M98.18M
Cash, Cash Equivalents and Short-Term Investments190.06M98.78M24.95M120.23M178.66M77.07M
Total Debt425.00K5.30M9.81M760.00K956.00K1.31M
Total Liabilities21.30M23.33M48.93M18.51M22.18M10.54M
Stockholders Equity231.14M139.56M105.53M207.18M218.72M87.65M
Cash Flow
Free Cash Flow-78.33M-61.05M-109.90M-146.20M-110.86M-57.13M
Operating Cash Flow-74.82M-60.92M-102.00M-98.05M-75.56M-48.57M
Investing Cash Flow-3.51M-120.00K-29.07M-48.15M-35.31M-8.56M
Financing Cash Flow240.54M134.87M36.52M87.84M212.49M123.11M

Tonix Pharma Technical Analysis

Technical Analysis Sentiment
Negative
Last Price15.08
Price Trends
50DMA
17.16
Negative
100DMA
21.62
Negative
200DMA
26.90
Negative
Market Momentum
MACD
-0.70
Positive
RSI
37.29
Neutral
STOCH
17.20
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TNXP, the sentiment is Negative. The current price of 15.08 is below the 20-day moving average (MA) of 17.10, below the 50-day MA of 17.16, and below the 200-day MA of 26.90, indicating a bearish trend. The MACD of -0.70 indicates Positive momentum. The RSI at 37.29 is Neutral, neither overbought nor oversold. The STOCH value of 17.20 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for TNXP.

Tonix Pharma Risk Analysis

Tonix Pharma disclosed 66 risk factors in its most recent earnings report. Tonix Pharma reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Tonix Pharma Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
56
Neutral
$142.35M25.6112.64%35.42%
56
Neutral
$293.88M-5.92-110.72%77.08%
55
Neutral
$288.42M-174.79%-76.59%94.03%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
$116.51M-52.35%-46.92%20.26%
49
Neutral
$169.78M-2.96-271.32%-75.77%-31.24%
43
Neutral
$196.42M-0.02-64.99%-8.79%81.36%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
TNXP
Tonix Pharma
15.17
-12.70
-45.57%
PLX
Protalix
2.00
-0.27
-11.89%
FATE
Fate Therapeutics
1.06
-0.61
-36.53%
AVTX
Avalo Therapeutics
17.11
10.11
144.43%
FBRX
Forte Biosciences
24.18
6.40
36.00%
IPHA
Innate Pharma
1.74
-0.09
-4.92%

Tonix Pharma Corporate Events

Private Placements and Financing
Tonix Pharma Announces $20 Million Registered Direct Offering
Neutral
Dec 29, 2025

On December 29, 2025, Tonix Pharmaceuticals entered into a securities purchase agreement with a single institutional investor for a registered direct offering comprising 615,025 shares of common stock and pre-funded warrants to purchase an additional 615,025 shares, at per-share and per-warrant prices of $16.26 and $16.259, respectively. The transaction, expected to close on or about December 30, 2025, is anticipated to generate approximately $20 million in gross proceeds and includes standard terms such as ownership caps on warrant exercises, short-term restrictions on Tonix issuing additional equity or variable-rate securities, and 30-day lock-up agreements for directors and officers; TD Securities (USA) LLC is acting as placement agent and will receive a 6% cash fee on the gross proceeds, underscoring Tonix’s continued reliance on equity-linked financings to support its operations and balance sheet while signaling to stakeholders a willingness to accept issuance constraints in exchange for near-term capital.

The most recent analyst rating on (TNXP) stock is a Hold with a $18.00 price target. To see the full list of analyst forecasts on Tonix Pharma stock, see the TNXP Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Tonix Pharma advances TNX-4800 Lyme disease program
Positive
Dec 29, 2025

On December 29, 2025, Tonix Pharmaceuticals announced updated plans for its TNX-4800 Lyme disease prophylaxis program, including a scheduled 2026 meeting with the U.S. Food and Drug Administration to explore Phase 2/3 development options and the potential use of a controlled human infection model involving Borrelia-infected ticks to demonstrate efficacy. The company reported results from a randomized, double-blind, dose-escalation study in 44 healthy adults showing that single subcutaneous doses up to 10 mg/kg were generally safe and well tolerated, with mostly mild or moderate adverse events, rapid systemic absorption, long-lasting serum levels measurable for up to 12 months, low incidence of anti-drug antibodies, and drug exposure well below levels associated with toxicity in animal studies, underscoring TNX-4800’s potential as an annually administered alternative to traditional Lyme vaccines and signaling a strategic step toward later-stage clinical development.

The most recent analyst rating on (TNXP) stock is a Hold with a $18.00 price target. To see the full list of analyst forecasts on Tonix Pharma stock, see the TNXP Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Tonix Pharma Secures Rights to TNX-4900 for Pain Management
Positive
Dec 16, 2025

On December 16, 2025, Tonix Pharmaceuticals announced it has secured exclusive worldwide rights to TNX-4900, a promising non-opioid treatment for chronic neuropathic pain, from Rutgers University. This licensing agreement highlights Tonix’s strategic move to enhance its portfolio with a highly selective Sigma-1 receptor antagonist, which has shown significant efficacy and safety in preclinical models, potentially positioning the company as a leader in non-opioid pain management solutions.

The most recent analyst rating on (TNXP) stock is a Hold with a $20.00 price target. To see the full list of analyst forecasts on Tonix Pharma stock, see the TNXP Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Tonix Pharma Appoints New General Counsel
Positive
Dec 9, 2025

On December 9, 2025, Tonix Pharmaceuticals announced the appointment of Irina Ishak as General Counsel. Ms. Ishak, with over 25 years of experience in the life sciences industry, will lead the company’s legal, corporate governance, and compliance functions. Her appointment is expected to support Tonix’s commercialization efforts and strategic growth, particularly following the recent FDA approval of their fibromyalgia treatment, TONMYA.

The most recent analyst rating on (TNXP) stock is a Hold with a $19.50 price target. To see the full list of analyst forecasts on Tonix Pharma stock, see the TNXP Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Tonix Pharma’s IND Clearance Boosts MDD Treatment Efforts
Positive
Nov 24, 2025

On November 24, 2025, Tonix Pharmaceuticals announced that the FDA cleared their IND application for TNX-102 SL, a sublingual tablet designed to treat major depressive disorder in adults. The clearance allows the company to proceed with the Phase 2 HORIZON study, a 6-week trial involving 360 patients across 30 U.S. sites, comparing TNX-102 SL to a placebo. This development marks a significant step in Tonix’s clinical development efforts and could impact their market positioning by addressing unmet needs in MDD treatment.

The most recent analyst rating on (TNXP) stock is a Sell with a $17.00 price target. To see the full list of analyst forecasts on Tonix Pharma stock, see the TNXP Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Tonix Pharma Amends Sales Agreement to Raise Capital
Positive
Nov 21, 2025

On November 21, 2025, Tonix Pharmaceuticals amended its Sales Agreement with A.G.P./Alliance Global Partners to increase the maximum aggregate offering price of shares from $150 million to $400 million. This amendment allows Tonix to potentially raise more capital, which could enhance its operational capabilities and strengthen its market position.

The most recent analyst rating on (TNXP) stock is a Sell with a $17.00 price target. To see the full list of analyst forecasts on Tonix Pharma stock, see the TNXP Stock Forecast page.

Stock Buyback
Tonix Pharma Expands Share Repurchase Program
Positive
Nov 18, 2025

On November 18, 2025, Tonix Pharmaceuticals Holding Corp. announced that its Board of Directors approved an increase to its share repurchase program. The company may now repurchase up to an additional $25 million in value of its outstanding common stock, raising the total authorized shares under the program to $35 million.

The most recent analyst rating on (TNXP) stock is a Sell with a $17.00 price target. To see the full list of analyst forecasts on Tonix Pharma stock, see the TNXP Stock Forecast page.

Product-Related Announcements
Tonix Pharma Launches TONMYA Tablets in U.S.
Positive
Nov 17, 2025

On November 17, 2025, Tonix Pharmaceuticals announced that its product, TONMYATM (cyclobenzaprine HCl sublingual tablets), is now commercially available by prescription in U.S. pharmacies. This development marks a significant step for the company, potentially enhancing its market presence and offering new treatment options for patients, thereby impacting stakeholders positively.

The most recent analyst rating on (TNXP) stock is a Sell with a $17.00 price target. To see the full list of analyst forecasts on Tonix Pharma stock, see the TNXP Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Tonix Pharma Begins FOCUS Study on AVP-D Treatment
Neutral
Oct 22, 2025

On October 22, 2025, Tonix Pharmaceuticals announced that the first patient was dosed in the FOCUS study at Massachusetts General Hospital, targeting adult patients with arginine-vasopressin deficiency (AVP-D). The study is a randomized, double-blind, placebo-controlled crossover pilot designed to evaluate the company’s intranasal potentiated oxytocin products, TNX-2900 and TNX-1900, on markers of anxiety, depression, and socioemotional functioning. This trial aims to generate preliminary data for future studies on oxytocin replacement therapy, potentially impacting the treatment landscape for AVP-D and improving patient quality of life.

The most recent analyst rating on (TNXP) stock is a Hold with a $41.00 price target. To see the full list of analyst forecasts on Tonix Pharma stock, see the TNXP Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Tonix Pharma Plans Phase 2 Trial for 2026
Positive
Oct 7, 2025

Tonix Pharmaceuticals announced plans to initiate a Phase 2 trial of its TNX-102 SL product candidate for major depressive disorder in 2026, and an adaptive Phase 2/3 study of TNX-4800 for the seasonal prevention of Lyme disease in 2027. These developments are part of the company’s strategic efforts to expand its clinical pipeline and strengthen its position in the pharmaceutical market.

The most recent analyst rating on (TNXP) stock is a Hold with a $41.00 price target. To see the full list of analyst forecasts on Tonix Pharma stock, see the TNXP Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 31, 2025