Takeda Pharmaceutical Company (TAK)
:TAK
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Takeda Pharmaceutical Company (TAK) AI Stock Analysis

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TAK

Takeda Pharmaceutical Company

(NYSE:TAK)

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Neutral 63 (OpenAI - 4o)
Rating:63Neutral
Price Target:
$15.00
▲(6.53% Upside)
Takeda Pharmaceutical's overall stock score reflects a stable financial position with strong cash flow generation but faces challenges in revenue growth and profitability. The technical analysis indicates a bearish trend, and the high P/E ratio suggests potential overvaluation despite a strong dividend yield. The earnings call highlighted both opportunities in pipeline advancements and strategic partnerships, as well as risks from VYVANSE's generic impact and currency headwinds.
Positive Factors
Strategic Partnerships
The partnership with Innovent Biologics enhances Takeda's oncology pipeline, leveraging synergies to develop transformative cancer treatments, which could strengthen its market position in oncology over the long term.
Cash Flow Generation
Strong cash flow growth enhances Takeda's financial flexibility, allowing for strategic investments and debt management, supporting long-term business sustainability.
Vaccine Development
Successful completion of the TIDES trial for Qdenga positions Takeda to capitalize on global vaccine markets, potentially driving future revenue growth and market expansion.
Negative Factors
Revenue Decline
Negative revenue growth indicates potential market or operational challenges, which could impact Takeda's ability to maintain its competitive position and financial performance.
Profitability Challenges
Declining net profit margins suggest difficulties in maintaining profitability, which could affect Takeda's ability to reinvest in growth initiatives and sustain long-term competitiveness.
Impairment Losses
Significant impairment losses from discontinued cell therapy efforts highlight resource allocation challenges, potentially impacting future profitability and strategic focus.

Takeda Pharmaceutical Company (TAK) vs. SPDR S&P 500 ETF (SPY)

Takeda Pharmaceutical Company Business Overview & Revenue Model

Company DescriptionTakeda Pharmaceutical Company Limited is a global, research and development-driven pharmaceutical company headquartered in Japan. Established in 1781, Takeda specializes in innovative medicines and has a diverse portfolio that includes treatments for oncology, gastroenterology, neuroscience, and rare diseases. The company is committed to improving patient outcomes through its extensive pipeline of therapies and a strong focus on biopharmaceuticals, including vaccines and plasma-derived therapies.
How the Company Makes MoneyTakeda generates revenue primarily through the sale of prescription pharmaceuticals, which are developed and marketed for various therapeutic areas, including oncology, gastrointestinal disorders, and rare diseases. The company has a robust pipeline of drugs that contribute to its revenue stream through both new product launches and ongoing sales of established medications. Additionally, Takeda engages in strategic partnerships and collaborations with other pharmaceutical companies, research institutions, and biotech firms, which can provide additional revenue through licensing agreements and joint ventures. The company also benefits from its focus on biologics and specialty medicines, which generally have higher price points and demand. Furthermore, Takeda's global presence allows it to tap into diverse markets, enhancing its overall sales potential and stability.

Takeda Pharmaceutical Company Key Performance Indicators (KPIs)

Any
Any
Revenue by Geography
Revenue by Geography
Breaks down revenue across different regions, revealing where the company is strongest and where it may face risk or growth potential due to local economic conditions or market share shifts.
Chart InsightsTakeda's revenue growth in the U.S. and Europe/Canada has been robust, driven by their Growth and Launch Product portfolio, which now makes up 48% of core revenue. Despite challenges like VYVANSE's generic impact and ENTYVIO's underperformance in the U.S., Takeda's strategic focus on biopharmaceutical innovations and operational efficiencies has bolstered their financial position. The company plans significant investments in the U.S. market, aiming to sustain momentum and offset revenue pressures from generic competition and market challenges in China.
Data provided by:Main Street Data

Takeda Pharmaceutical Company Earnings Call Summary

Earnings Call Date:Oct 30, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Jan 29, 2026
Earnings Call Sentiment Neutral
The earnings call presented a mixed outlook with strong pipeline advancements and strategic partnerships, but was overshadowed by significant losses from VYVANSE's generic impact and currency headwinds affecting profitability.
Q2-2025 Updates
Positive Updates
Growth in Launch Products
Launch products grew 5.3% at constant exchange rate (CER), with expectations for higher growth in the second half of the fiscal year.
Pipeline Advancements
Positive Phase III studies for rusfertide and oveporexton, and expected Phase III data for zasocitinib in psoriasis by the end of the calendar year.
Innovent Biologics Partnership
Strategic partnership with Innovent Biologics to expand oncology pipeline with differentiated assets like IBI363 and IBI343.
Oveporexton's Potential
Oveporexton demonstrates significant improvement in narcolepsy type 1 symptoms and is on track for U.S. filing later in the year.
Strong Cash Flow
Adjusted free cash flow of JPY 525.4 billion, including improvements in working capital.
Negative Updates
VYVANSE Revenue Impact
Loss of exclusivity for VYVANSE resulted in a revenue loss of approximately JPY 100 billion, impacting the first half results.
Currency Headwinds
Transactional foreign exchange impacts, particularly from the euro, affected profitability and led to a slight reduction in profit guidance.
ENTYVIO Growth Revision
ENTYVIO's growth was revised down to 6% at CER due to competitive pressures and slower-than-expected pen conversion.
Impairment Losses
Reported operating profit decreased by 27.7% due to larger impairment losses, including a JPY 58.2 billion expense related to discontinuing cell therapy efforts.
Challenges in China
Albumin sales in China declined slightly due to timing of shipments and cost containment measures, although growth is expected to accelerate in the second half.
Company Guidance
During Takeda's FY 2025 Q2 earnings call, the company provided guidance on several key metrics. The first half of the fiscal year saw a significant impact from the loss of exclusivity (LOE) of VYVANSE, resulting in a revenue loss of approximately JPY 100 billion. Despite this, the company maintained tight OpEx control, which partially offset the impact on corporate profit. Takeda updated its full-year guidance for core operating profit and core EPS due to a headwind from transactional foreign exchange, largely driven by the euro's appreciation. The company reported H1 revenue of over JPY 2.2 trillion, a decrease of 6.9% year-on-year, or 3.9% at constant exchange rates (CER). Core operating profit was JPY 639.2 billion, down 11.2% at actual FX or 8.8% at CER. Reported operating profit stood at JPY 253.6 billion, a 27.7% decline due to larger impairment losses, primarily related to cell therapy discontinuation. The company expects better growth dynamics in H2 as the VYVANSE impact moderates and growth in launch products accelerates. Takeda also highlighted its strategic partnership with Innovent Biologics, which is expected to enrich its late-stage pipeline with promising oncology assets.

Takeda Pharmaceutical Company Financial Statement Overview

Summary
Takeda Pharmaceutical demonstrates a stable financial position with strengths in cash flow generation and a balanced leverage profile. However, challenges in revenue growth and profitability margins highlight areas for improvement. The company maintains a solid equity base, supporting long-term stability amidst industry-specific challenges.
Income Statement
65
Positive
Takeda Pharmaceutical's income statement shows moderate performance. The TTM (Trailing-Twelve-Months) gross profit margin is strong at 60.54%, indicating efficient cost management. However, the net profit margin has declined to 3.06%, reflecting challenges in maintaining profitability. Revenue growth has been negative recently, with a -2.21% decline, suggesting potential market or operational challenges. EBIT and EBITDA margins are stable but show room for improvement.
Balance Sheet
70
Positive
The balance sheet reflects a stable financial position with a debt-to-equity ratio of 0.66, indicating a balanced approach to leveraging. The return on equity (ROE) is modest at 1.95%, suggesting limited returns on shareholder investments. The equity ratio is healthy, showing a strong equity base relative to total assets, which enhances financial stability.
Cash Flow
75
Positive
Cash flow analysis reveals a positive trajectory with a 15.98% growth in free cash flow, indicating improved cash generation capabilities. The operating cash flow to net income ratio is 0.49, suggesting efficient cash conversion from earnings. The free cash flow to net income ratio of 0.78 reflects a strong ability to generate cash relative to net income, supporting financial flexibility.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue4.42T4.58T4.26T4.03T3.57T3.20T
Gross Profit2.85T3.00T2.83T2.78T2.46T2.20T
EBITDA1.13T1.21T1.14T1.28T1.18T983.72B
Net Income33.03B107.93B144.07B317.02B230.06B376.00B
Balance Sheet
Total Assets14.47T14.25T15.11T13.96T13.18T12.91T
Cash, Cash Equivalents and Short-Term Investments739.68B405.59B472.89B553.70B875.00B1.00T
Total Debt4.65T5.07T5.46T4.86T4.81T4.64T
Total Liabilities7.34T7.31T7.83T7.60T7.49T7.74T
Stockholders Equity7.13T6.94T7.27T6.35T5.68T5.17T
Cash Flow
Free Cash Flow977.79B856.39B235.61B343.47B937.07B774.46B
Operating Cash Flow1.20T1.06T716.34B977.16B1.12T1.01T
Investing Cash Flow-216.56B-367.06B-463.86B-607.10B-198.13B393.53B
Financing Cash Flow-1.18T-751.42B-354.42B-709.15B-1.07T-1.09T

Takeda Pharmaceutical Company Technical Analysis

Technical Analysis Sentiment
Negative
Last Price14.08
Price Trends
50DMA
14.29
Negative
100DMA
14.56
Negative
200DMA
14.54
Negative
Market Momentum
MACD
-0.02
Negative
RSI
51.86
Neutral
STOCH
72.46
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For TAK, the sentiment is Negative. The current price of 14.08 is above the 20-day moving average (MA) of 13.87, below the 50-day MA of 14.29, and below the 200-day MA of 14.54, indicating a neutral trend. The MACD of -0.02 indicates Negative momentum. The RSI at 51.86 is Neutral, neither overbought nor oversold. The STOCH value of 72.46 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for TAK.

Takeda Pharmaceutical Company Risk Analysis

Takeda Pharmaceutical Company disclosed 39 risk factors in its most recent earnings report. Takeda Pharmaceutical Company reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Takeda Pharmaceutical Company Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
79
Outperform
$14.44B34.2814.96%19.61%11.36%
73
Outperform
$11.72B17.0917.72%0.65%10.63%6.35%
67
Neutral
$41.49B21.439.20%1.83%0.58%45.74%
63
Neutral
$45.36B169.510.54%4.25%-1.98%-86.20%
63
Neutral
$29.76B40.1610.77%-0.25%
60
Neutral
$12.35B-21.09%4.58%-6.40%-320.23%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
TAK
Takeda Pharmaceutical Company
14.07
1.06
8.15%
RDY
Dr Reddy's Laboratories
14.02
-0.21
-1.48%
VTRS
Viatris
10.71
-1.81
-14.46%
NBIX
Neurocrine
138.63
15.34
12.44%
TEVA
Teva Pharmaceutical
24.84
7.81
45.86%
HLN
Haleon PLC Sponsored ADR
9.61
0.30
3.22%

Takeda Pharmaceutical Company Corporate Events

Takeda’s Earnings Call: Mixed Outlook Amid Challenges
Nov 4, 2025

Takeda Pharmaceutical Company’s recent earnings call presented a mixed outlook, highlighting both promising developments and notable challenges. While the company showcased strong pipeline advancements and strategic partnerships, these positives were overshadowed by significant losses from VYVANSE’s generic impact and currency headwinds affecting profitability.

Takeda Pharmaceutical Reports Decline in Revenue and Profit
Oct 31, 2025

Takeda Pharmaceutical Company Limited is a global pharmaceutical company based in Japan, focusing on research and development in areas such as oncology, gastroenterology, and neuroscience. It is listed on multiple stock exchanges, including Tokyo and Nagoya.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 18, 2025