Clinical Execution And Dosing UncertaintyUncertainty around execution, dose optimization, and indication prioritization raises questions about how quickly clinical dosing can reach exposure levels associated with preclinical efficacy.
Need For Clinical ValidationSignificant clinical validation is required to confirm competitive differentiation despite encouraging preclinical results, creating meaningful outcome risk for investors.
Pipeline Setbacks And Early-stage RiskDiscontinuation of a prior asset in a key indication combined with a predominantly preclinical pipeline underscores execution risk and positions the company as a longer-term, higher-risk investment.