Clinical Trial ChallengesThe Phase 2 MINDFuL study in Alzheimer's disease for XPro missed the primary endpoint for cognitive change, leading to a significant drop in INMB shares.
Development RisksThe timeline for the Alzheimer's program has been extended to 2033, with increased revenue risk adjustment, reflecting challenges in the development process.
Efficacy ConcernsThe Phase 2 study showed an effect size only in a subset of patients with greater neuroinflammation, suggesting limited broader efficacy.