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Inmune Bio (INMB)
NASDAQ:INMB

Inmune Bio (INMB) AI Stock Analysis

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INMB

Inmune Bio

(NASDAQ:INMB)

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Neutral 46 (OpenAI - 5.2)
Rating:46Neutral
Price Target:
$1.50
▼(-1.96% Downside)
Overall score is held down primarily by weak financial performance (minimal revenue, large losses, and ongoing cash burn) and bearish technical trend (trading below major moving averages). The earnings call provided some support via improved quarterly loss, stated runway into Q4 2026, and pipeline/regulatory progress, but clinical/regulatory uncertainties (XPro topline miss and timing delays) and a negative P/E limit the score.
Positive Factors
Intellectual Property
Securing a favorable patentability opinion enhances INmune Bio's intellectual property portfolio, potentially providing market exclusivity until 2045. This strengthens the company's competitive position and supports long-term strategic growth in the biotechnology sector.
Pipeline Progress
The anticipated Phase 2 trial results for XPro in Alzheimer's disease could significantly enhance INmune Bio's market position in neurodegenerative therapies, demonstrating the company's innovative approach and potential to address unmet medical needs.
Strategic Partnerships
The license agreement for CORDStrom data with a leading hospital enhances INmune Bio's ability to commercialize its therapies in the US and Europe, potentially accelerating market entry and expanding revenue streams through strategic collaborations.
Negative Factors
Financial Performance
The sharp decline in revenue and ongoing losses highlight financial instability, which could hinder INmune Bio's ability to fund R&D and operational activities, impacting long-term growth and sustainability in the competitive biotech industry.
Cash Flow Challenges
Negative cash flows and increased cash burn indicate reliance on external funding, which can strain financial resources and limit operational flexibility, posing risks to INmune Bio's long-term financial health and ability to sustain its pipeline development.
Screening Failure Rate
The high screening failure rate in the Alzheimer's trial could delay clinical progress and increase costs, challenging INmune Bio's ability to efficiently advance its pipeline and achieve timely regulatory approvals, impacting strategic objectives.

Inmune Bio (INMB) vs. SPDR S&P 500 ETF (SPY)

Inmune Bio Business Overview & Revenue Model

Company DescriptionINmune Bio, Inc., a clinical-stage immunotherapy company, focuses on developing drugs to reprogram the patient's innate immune system to treat disease. The company develops and commercializes product candidates to treat hematologic malignancies, solid tumors, and chronic inflammation. Its development programs include INKmune, which focuses on treating women with relapse refractory ovarian carcinoma and patients with high-risk myelodysplastic syndrome; INB03, an immunotherapy that treats patients with hematologic malignancies and solid tumors; and XPro1595 for the treatment of Alzheimer's disease. The company has license agreements with Xencor, Inc.; Immune Ventures, LLC; University of Pittsburg; and University College London. INmune Bio, Inc. was incorporated in 2015 and is headquartered in Boca Raton, Florida.
How the Company Makes MoneyInmune Bio primarily generates revenue through strategic partnerships, licensing agreements, and potential future sales of its proprietary therapies upon approval. The company may receive upfront payments, milestone payments, and royalties from its collaborative partners. Additionally, Inmune Bio could benefit from government grants and research funding to support its scientific advancements. As its therapies progress through clinical trials and obtain regulatory approvals, commercializing these treatments will be critical for driving significant revenue growth.

Inmune Bio Earnings Call Summary

Earnings Call Date:Oct 30, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 26, 2026
Earnings Call Sentiment Positive
The earnings call reflected a generally positive sentiment with significant advancements in CORDStrom and INKmune platforms, as well as promising regulatory pathways for XPro. Financial results showed improved operating efficiency, although challenges with XPro trial results and regulatory delays were noted.
Q3-2025 Updates
Positive Updates
CORDStrom Advances Towards Regulatory Approval
CORDStrom is being prepared for submission for marketing approval in the U.K. and the U.S., showing significant improvements in patients with recessive dystrophic epidermolysis bullosa (RDEB), particularly in reducing itch and improving quality of life.
XPro Potential in Alzheimer's Disease
The XPro platform is making progress with positive results in patients with higher baseline inflammation. The company is pursuing an accelerated regulatory pathway and preparing for an end of Phase II meeting with the FDA.
INKmune Phase II Success in Prostate Cancer
INKmune completed its Phase II trial in prostate cancer ahead of schedule, meeting the primary endpoint and two of the three secondary endpoints.
Financial Position and Reduced Loss
Net loss for the quarter decreased to approximately $6.5 million from $12.1 million in the same period last year. The company has cash reserves of approximately $27.7 million, sufficient to fund operations into Q4 2026.
Negative Updates
Challenges with XPro Trial Results
Despite efforts, the company missed the top line on the MINDFuL trial for XPro, although they remain optimistic about its potential.
Delay in FDA Meeting for XPro
The expected end of Phase II meeting with the FDA for XPro has been delayed to Q1 2026 instead of occurring before year-end 2025.
Company Guidance
During INmune Bio's third quarter 2025 earnings call, the company provided several key guidance metrics. They reported a net loss of approximately $6.5 million, a significant improvement from the $12.1 million loss in the same period of 2024. Research and development expenses were $4.9 million, down from $10.1 million in the previous year. General and administrative expenses slightly increased to $2.5 million from $2.2 million. As of September 30, 2025, the company held $27.7 million in cash and cash equivalents, which they project will fund operations into Q4 2026. INmune Bio is focused on advancing their platform programs, notably planning to file a marketing authorization application (MAA) for CORDStrom in the UK by mid-2026 and subsequently a biologics licensing application (BLA) in the US. They are also pursuing an accelerated regulatory pathway for their XPro platform in Alzheimer's treatment and expect regulatory alignment with the FDA by Q1 2026.

Inmune Bio Financial Statement Overview

Summary
Inmune Bio's financial performance is weak, with a sharp decline in revenue and persistent losses. Despite a relatively strong equity position and decreasing debt-to-equity ratio, the company's ongoing cash burn and negative cash flows highlight significant financial distress.
Income Statement
8
Very Negative
Inmune Bio has shown a significant decline in revenue, with a steep drop from $77.69 million in 2019 to $14,000 in 2024. The company consistently records negative net income and EBIT, highlighting ongoing unprofitability. Margins are severely negative, and the shrinking revenue base raises concerns about future growth prospects.
Balance Sheet
52
Neutral
The company maintains a relatively strong equity position with a decreasing debt-to-equity ratio, indicating potential stability in its financial leverage. However, the overall reduction in total assets and equity suggests a diminishing scale of operations, which might affect future growth capabilities.
Cash Flow
12
Very Negative
Operating cash flows remain negative, reflecting ongoing operational challenges. There was a significant decrease in free cash flow over recent periods, indicating increased cash burn. Positive financing cash flows in some years suggest reliance on external funding to sustain operations.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue50.00K14.00K155.00K374.00K181.00K11.00K
Gross Profit22.00K14.00K155.00K374.00K181.00K11.00K
EBITDA-33.62M-42.08M0.000.000.000.00
Net Income-49.89M-42.08M-30.01M-27.30M-30.34M-12.10M
Balance Sheet
Total Assets33.36M39.56M57.00M81.80M99.94M40.66M
Cash, Cash Equivalents and Short-Term Investments27.73M20.92M35.85M52.15M74.81M21.97M
Total Debt1.08M384.00K10.44M15.31M15.23M160.00K
Total Liabilities7.98M7.46M18.86M21.69M19.72M1.90M
Stockholders Equity25.38M32.10M38.14M60.10M80.22M38.75M
Cash Flow
Free Cash Flow-31.55M-33.36M-11.98M-22.69M-43.50M-8.94M
Operating Cash Flow-30.65M-33.36M-11.98M-22.69M-28.50M-8.94M
Investing Cash Flow-899.00K0.000.000.00-15.00M0.00
Financing Cash Flow25.47M18.21M-4.22M729.00K96.36M23.90M

Inmune Bio Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price1.53
Price Trends
50DMA
1.68
Negative
100DMA
1.81
Negative
200DMA
3.65
Negative
Market Momentum
MACD
-0.07
Positive
RSI
48.83
Neutral
STOCH
58.16
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For INMB, the sentiment is Neutral. The current price of 1.53 is below the 20-day moving average (MA) of 1.64, below the 50-day MA of 1.68, and below the 200-day MA of 3.65, indicating a bearish trend. The MACD of -0.07 indicates Positive momentum. The RSI at 48.83 is Neutral, neither overbought nor oversold. The STOCH value of 58.16 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for INMB.

Inmune Bio Risk Analysis

Inmune Bio disclosed 59 risk factors in its most recent earnings report. Inmune Bio reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Inmune Bio Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
48
Neutral
$131.65M-0.46-3.98%-29.94%
46
Neutral
$40.94M-0.76-155.77%19.05%2.01%
45
Neutral
$37.56M-1.90-61.92%-100.00%55.10%
44
Neutral
$38.35M-0.39-15.81%-113.06%
42
Neutral
$31.11M-0.61-195.19%-25.51%49.72%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
INMB
Inmune Bio
1.63
-5.09
-75.74%
VERU
Veru
2.42
-6.02
-71.33%
KPTI
Karyopharm Therapeutics
6.66
-3.81
-36.41%
CUE
Cue Biopharma
0.28
-1.00
-78.36%
CELU
Celularity
1.29
-0.91
-41.36%
JUNS
Jupiter Neurosciences, Inc.
0.86
-3.41
-79.81%

Inmune Bio Corporate Events

Business Operations and StrategyPrivate Placements and Financing
Inmune Bio Amends April 2024 Investor Warrants
Positive
Dec 23, 2025

On December 22, 2025, INmune Bio Inc. amended certain investor warrants issued in its April 24 and April 29, 2024 offerings, adjusting the terms on 1,348,315 outstanding warrants. The company reduced the exercise price of these April 2024 warrants to $1.95, a level above Nasdaq’s defined minimum price as of December 17, 2025, and extended their expiration date to June 30, 2026, in exchange for a $0.05 per warrant payment, generating $67,416 in proceeds and potentially improving the warrants’ attractiveness to holders while modestly strengthening the company’s near-term funding flexibility.

The most recent analyst rating on (INMB) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Inmune Bio stock, see the INMB Stock Forecast page.

Business Operations and StrategyPrivate Placements and FinancingRegulatory Filings and Compliance
INmune Bio Establishes $65 Million At-The-Market Offering
Neutral
Dec 19, 2025

On December 19, 2025, INmune Bio Inc. entered into a sales agreement with A.G.P./Alliance Global Partners, allowing the company to sell up to $65 million of its common stock from time to time through at-the-market offerings under an existing shelf registration. The company is not obligated to issue any shares, but A.G.P. will act as sales agent subject to customary conditions, earning a 3% commission on gross proceeds and receiving indemnification, contribution rights, and expense reimbursements, providing INmune Bio with flexible access to additional capital that could support its operational and development needs while potentially diluting existing shareholders over time.

The most recent analyst rating on (INMB) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Inmune Bio stock, see the INMB Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Inmune Bio Ends Sales Agreement with RBC and BTIG
Neutral
Dec 10, 2025

INmune Bio Inc. announced the termination of its Amended and Restated At-The-Market Sales Agreement with RBC Capital Markets, LLC and BTIG, LLC, effective December 19, 2025. The company had previously raised approximately $10.5 million through the sale of 1,353,469 shares of common stock under this agreement, and the termination incurs no penalties or additional expenses.

The most recent analyst rating on (INMB) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Inmune Bio stock, see the INMB Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Inmune Bio Unveils Promising Alzheimer’s Trial Data
Positive
Dec 5, 2025

On December 1, 2025, INmune Bio Inc. announced new neuroimaging data from its Phase 2 MINDFuL trial of XPro1595, presented at the Clinical Trials on Alzheimer’s Disease conference. The data, which showed a trend towards slowed neurodegeneration in patients with early Alzheimer’s disease and high inflammatory burden, reinforce XPro1595’s potential as a promising therapy for inflammation-driven Alzheimer’s, a large unmet market need.

The most recent analyst rating on (INMB) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Inmune Bio stock, see the INMB Stock Forecast page.

Executive/Board Changes
Inmune Bio Updates Executive Employment Agreements
Neutral
Dec 3, 2025

On December 2, 2025, INmune Bio Inc. announced amendments to the employment agreements of its President and Chief Executive, David J. Moss, and its Chief Financial Officer, Cory Ellspermann. The amendments corrected errors in the original agreements dated November 26, 2025, adjusting Moss’s base salary to $454,000 per annum and his stock option grant to 750,000 shares, while Ellspermann’s base salary was restated to $240,000 per annum.

The most recent analyst rating on (INMB) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Inmune Bio stock, see the INMB Stock Forecast page.

Executive/Board Changes
Inmune Bio Announces New Executive Employment Agreements
Neutral
Nov 28, 2025

On November 26, 2025, INmune Bio Inc. announced new employment agreements for key executives, effective November 1, 2025. David J. Moss, President and CEO, will receive a base salary of $500,000, a discretionary bonus, and stock options, with provisions for change of control and involuntary termination. Cory Ellspermann, CFO, will have a base salary of $275,000, a discretionary bonus, and stock options, with similar provisions. Mark Lowdell, Chief Scientific Officer, under the subsidiary INmune Bio International Limited, will receive a salary of £300,000, a discretionary bonus, and benefits, with terms for termination and severance. These agreements aim to secure leadership stability and align executive incentives with company performance.

The most recent analyst rating on (INMB) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Inmune Bio stock, see the INMB Stock Forecast page.

Business Operations and StrategyShareholder Meetings
INmune Bio Approves Option Repricing Proposal
Neutral
Nov 18, 2025

On November 18, 2025, INmune Bio held a virtual special meeting of stockholders where the Option Repricing Proposal was approved. The company also announced its participation in the 18th Clinical Trials on Alzheimer’s Disease conference in December 2025, where it will present results from its Phase 2 MINDFuL trial and validation of the Early Mild Alzheimer’s Cognitive Composite.

The most recent analyst rating on (INMB) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Inmune Bio stock, see the INMB Stock Forecast page.

Business Operations and StrategyProduct-Related AnnouncementsRegulatory Filings and Compliance
Inmune Bio Advances Immunotherapy Pipeline with Phase 2 Completion
Positive
Nov 10, 2025

INmune Bio Inc. has prepared a presentation slide deck to be used in future presentations, highlighting their progress in developing immunotherapies. The company is advancing its late-stage pipeline with key programs like CORDStrom and XPro, targeting rare pediatric diseases and Alzheimer’s, respectively. They have completed Phase 2 trials for both programs and are planning regulatory filings and Phase 3 trials in the coming years. This strategic progression positions INmune Bio for regulatory acceleration and potential market entry, which could significantly impact their market presence and stakeholder interests.

The most recent analyst rating on (INMB) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Inmune Bio stock, see the INMB Stock Forecast page.

Business Operations and StrategyFinancial Disclosures
Inmune Bio to Host Q3 Results Conference Call
Neutral
Oct 28, 2025

On October 23, 2025, INmune Bio Inc. announced it will host a conference call on October 30, 2025, to discuss its third-quarter financial results and provide a corporate update. This event is significant for stakeholders as it will offer insights into the company’s recent performance and strategic direction, potentially impacting its market positioning and investor relations.

The most recent analyst rating on (INMB) stock is a Buy with a $8.00 price target. To see the full list of analyst forecasts on Inmune Bio stock, see the INMB Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 30, 2025