Adverse EventsTwo patients experienced reversible dose-limiting toxicities, including grade 3 mucositis and a grade 3 AST increase at 3,200 ng/kg.
Clinical ProgressionA melanoma patient dosed at 12 mg with a previous unconfirmed partial response progressed at week 16, showing new lesions near the sternum and portal vein.
Efficacy DataEarly monotherapy efficacy data for both programs did not live up to investors' expectations, and WTX-330 data suggests a narrower therapeutic window for masked native IL-12.