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Soleno Therapeutics Inc (SLNO)
NASDAQ:SLNO
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Soleno Therapeutics (SLNO) AI Stock Analysis

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SLNO

Soleno Therapeutics

(NASDAQ:SLNO)

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Underperform 37 (OpenAI - 4o)
Rating:37Underperform
Price Target:
Soleno Therapeutics shows high risk due to its lack of revenue and reliance on external financing. However, it maintains a solid equity base and is experiencing positive technical momentum, suggesting speculative interest. The valuation is typical for an early-stage biotech, with potential upside reliant on successful R&D outcomes.
Positive Factors
Solid Equity Base
A strong equity base provides financial stability, offering a cushion for ongoing R&D expenses and potential future investments.
Minimal Debt
Minimal debt levels reduce financial risk and interest obligations, allowing more resources to be allocated towards product development.
Focus on Rare Diseases
Targeting rare diseases can lead to market exclusivity and pricing power, enhancing long-term revenue potential upon successful product launch.
Negative Factors
Lack of Revenue
The absence of revenue generation indicates reliance on external funding, posing a risk to financial sustainability if product development is delayed.
Negative Cash Flow
Negative cash flow highlights ongoing cash burn, necessitating continuous external financing, which may dilute existing shareholders over time.
High Net Losses
Substantial net losses without offsetting revenue can strain financial resources, impacting the company's ability to sustain long-term operations.

Soleno Therapeutics (SLNO) vs. SPDR S&P 500 ETF (SPY)

Soleno Therapeutics Business Overview & Revenue Model

Company DescriptionSoleno Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of novel therapeutics for the treatment of rare diseases. Its lead candidate is Diazoxide Choline Controlled-Release, a once-daily oral tablet for the treatment of Prader-Willi Syndrome, which is being evaluated in an ongoing Phase III clinical development program. The company was formerly known as Capnia, Inc. and changed its name to Soleno Therapeutics, Inc. in May 2017. Soleno Therapeutics, Inc. was incorporated in 1999 and is based in Redwood City, California.
How the Company Makes MoneySoleno Therapeutics primarily makes money through the development and potential commercialization of its core product, DCCR tablets. The company aims to generate revenue by obtaining regulatory approval for DCCR and subsequently marketing it to healthcare providers and patients. Revenue streams are anticipated to include product sales, licensing agreements, and potential partnerships with pharmaceutical companies for distribution and commercialization. Soleno's financial performance is heavily dependent on the successful clinical development, regulatory approval, and market acceptance of its therapeutic products.

Soleno Therapeutics Earnings Call Summary

Earnings Call Date:Nov 04, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 11, 2026
Earnings Call Sentiment Positive
The earnings call presented significant positive developments, including strong revenue growth, profitability, and broad payer coverage for VYKAT XR. However, these were tempered by challenges such as increased discontinuation rates and the impact of a short seller report affecting market momentum.
Q3-2025 Updates
Positive Updates
Significant Revenue Growth and Profitability
Total net revenue more than doubled from the second quarter to $66 million, and the company achieved a positive net income of $26 million for the third quarter.
Strong Market Adoption of VYKAT XR
By the end of Q3, 764 individuals were actively treated with VYKAT XR, with 397 patient start forms in the third quarter.
Broad Payer Coverage
Policies cover approximately 132 million lives, including coverage policies with appropriate criteria from the top 3 national PBMs and broad access across commercial, Medicaid, and Medicare channels.
Progress in Regulatory Approval for DCCR in Europe
The company is progressing along regulatory pathways in Europe, responding to day 120 questions from the EMA.
Negative Updates
Increase in Discontinuation Rates
Since approval, the discontinuation rate of VYKAT XR related to adverse events was approximately 8% at the end of Q3, with total discontinuation at approximately 10%.
Impact of Short Seller Report
A short seller report released in mid-August caused a disruption in the launch trajectory, resulting in a lower number of start forms and increased discontinuations for nonserious adverse events.
Company Guidance
During Soleno Therapeutics' third quarter 2025 financial and operating results call, the company reported that their total net revenue more than doubled from the second quarter, reaching $66 million. They achieved profitability with a positive net income of $26 million. Key performance indicators showed progress, with 1,043 cumulative patient start forms and 764 active patients on VYKAT XR by the end of Q3. The number of unique prescribers increased to 494, and coverage was secured for approximately 132 million lives, including policies from top national PBMs. However, the period saw a disruption due to a short seller report, impacting patient start forms and increasing discontinuation rates, though efforts to educate and re-engage patients are underway. The company also continued to advance regulatory approval for DCCR in Europe, aiming to expand their market presence.

Soleno Therapeutics Financial Statement Overview

Summary
Soleno Therapeutics is in its developmental phase, with no revenue generation and substantial net losses. The company shows a strong equity base with minimal debt, but its financial health is heavily reliant on external financing due to the lack of operational cash inflow. This represents a high-risk profile typical for early-stage biotech firms.
Income Statement
10
Very Negative
Soleno Therapeutics has reported zero revenue consistently, indicating the company is yet in developmental stages with no commercialized products. The net losses have been substantial over the years, with no gross or net profit margins to evaluate, reflecting ongoing operational expenses without revenue generation. This indicates a high-risk profile typical for early-stage biotech firms.
Balance Sheet
35
Negative
The balance sheet shows a relatively high stockholders' equity compared to total assets, indicating a solid equity base. However, the total debt is minimal, which is positive, but the lack of revenue raises concerns about sustainability. The equity ratio is strong, but the absence of revenue impacts overall financial health adversely.
Cash Flow
20
Very Negative
Operating cash flow is negative, which is expected for a company in the biotechnology sector still in R&D phases. Free cash flow trends are also negative, highlighting ongoing cash burn without revenue inflow. Financing activities have supplemented cash flows significantly, hinting at reliance on external funding to support operations.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue98.67M0.000.000.000.000.00
Gross Profit96.84M0.00-1.96M0.000.00-2.19M
EBITDA-66.31M-173.63M-37.03M-22.10M-30.30M-22.45M
Net Income-78.45M-175.85M-38.99M-24.07M-30.91M-24.64M
Balance Sheet
Total Assets599.89M330.97M180.69M26.50M35.55M64.98M
Cash, Cash Equivalents and Short-Term Investments498.93M291.44M169.68M14.60M21.30M49.22M
Total Debt2.81M52.83M403.00K155.00K457.00K139.00K
Total Liabilities105.09M85.86M23.18M16.15M17.76M19.43M
Stockholders Equity494.81M245.11M157.51M10.35M17.79M45.55M
Cash Flow
Free Cash Flow-25.74M-69.31M-24.94M-20.79M-27.79M-25.23M
Operating Cash Flow-25.72M-69.10M-24.94M-20.78M-27.77M-25.22M
Investing Cash Flow-69.98M-225.68M0.00-13.00K-22.00K-7.00K
Financing Cash Flow293.95M213.03M180.02M14.09M-128.00K53.72M

Soleno Therapeutics Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price49.77
Price Trends
50DMA
58.53
Negative
100DMA
66.93
Negative
200DMA
66.96
Negative
Market Momentum
MACD
-3.83
Negative
RSI
43.71
Neutral
STOCH
64.11
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For SLNO, the sentiment is Neutral. The current price of 49.77 is below the 20-day moving average (MA) of 51.08, below the 50-day MA of 58.53, and below the 200-day MA of 66.96, indicating a bearish trend. The MACD of -3.83 indicates Negative momentum. The RSI at 43.71 is Neutral, neither overbought nor oversold. The STOCH value of 64.11 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for SLNO.

Soleno Therapeutics Risk Analysis

Soleno Therapeutics disclosed 64 risk factors in its most recent earnings report. Soleno Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Soleno Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
80
Outperform
$6.23B32.2319.66%54.51%275.94%
78
Outperform
$3.49B18.1063.17%27.62%202.89%
60
Neutral
$4.47B-34.53%-0.06%
52
Neutral
$7.28B-51.57%57.54%-36.57%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
40
Underperform
37
Underperform
$2.67B-20.66%44.84%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
SLNO
Soleno Therapeutics
49.55
-6.29
-11.26%
ADMA
ADMA Biologics
19.21
-2.62
-12.00%
MRUS
Merus
96.09
51.12
113.68%
KRYS
Krystal Biotech
218.70
21.79
11.07%
AKRO
Akero Therapeutics
54.36
22.19
68.98%
MTSR
Metsera, Inc.
70.50
42.70
153.60%

Soleno Therapeutics Corporate Events

Executive/Board ChangesBusiness Operations and Strategy
Soleno Therapeutics Enhances Executive Compensation Structure
Neutral
Jan 24, 2025

On January 21, 2025, Soleno Therapeutics’ Board of Directors approved increases to the base salaries for fiscal year 2025 and the payment of cash bonuses for fiscal year 2024 for its named executive officers, along with certain equity awards. This decision reflects the company’s ongoing efforts to enhance its executive compensation structure, which may impact its strategic operations and stakeholder expectations.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 10, 2025