ProQR (PRQR) AI Stock Analysis

• Market Cap: $250.41M
• Dividend Yield: N/A
• Average Volume (3M): 534.76K
• Price to Earnings (P/E): ―
• Beta (1Y): 1.75
• Revenue Growth: -11.99%
• EPS Growth: -42.04%
• Country: US
• Employees: 166
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.12
• Shares Outstanding: 105,212,524
• 10 Day Avg. Volume: 796,312
• 30 Day Avg. Volume: 534,757
• PEG Ratio: 2.63
• Price to Book (P/B): 2.36
• Price to Sales (P/S): 11.05
• P/FCF Ratio: -5.53
• Enterprise Value/Market Cap: 0.37
• Enterprise Value/Revenue: 5.91
• Enterprise Value/Gross Profit: 5.91
• Enterprise Value/Ebitda: -2.43
• 1Y Price Target: $7.25
• Price Target Upside: 234.10% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 4
• EPS Forecast (FY): N/A
• Revenue Forecast (FY): N/A

• Rating: 41 Neutral
• Price Target: $2.00 ▼(-7.83% Downside)

ProQR's overall stock score is primarily impacted by its financial performance and valuation challenges. The company's negative profitability and cash flow issues are significant concerns. Technical analysis indicates bearish momentum, further weighing on the stock's outlook. The lack of earnings call data and corporate events means these factors do not influence the score.

Positive Factors

Clinical Trial Advancement

The CTA authorization for AX-0810 marks a significant step in clinical development, potentially leading to new treatments for cholestatic diseases.

Pipeline and Platform Development

Advancing AX-0810 into trials demonstrates ProQR's commitment to expanding its RNA editing platform, which could drive future growth and innovation.

Cash Position

A strong cash position ensures financial stability and supports ongoing R&D efforts, enabling ProQR to pursue long-term strategic goals.

Negative Factors

Revenue Decline

Declining revenue indicates challenges in product sales and market penetration, potentially impacting future profitability and growth.

Profitability Challenges

Persistent negative profit margins highlight operational inefficiencies, posing risks to financial health and long-term sustainability.

Cash Flow Issues

Negative cash flow indicates difficulties in generating sufficient cash from operations, which could limit investment in growth initiatives.

ProQR Business Overview & Revenue Model

Company Description

ProQR Therapeutics N.V., a biopharmaceutical company, engages in the discovery and development of RNA-based therapeutics for the treatment of genetic disorders. It primarily develops sepofarsen that is in phase II/III clinical trial illuminate trial for treating leber congenital amaurosis 10 disease; and ultevursen, which is in phase II/III clinical trial to treat USH2A-mediated retinitis pigmentosa and usher syndrome. The company also engages in the developing of Axiomer RNA base-editing platform technology. It has a license agreement with Radboud University Medical Center, Inserm Transfert SA, Ionis Pharmaceuticals, Inc., and Leiden University Medical Center, as well as license and research collaboration with Eli Lilly and Company for the discovery, development, and commercialization of potential new medicines for genetic disorders in the liver and nervous system. ProQR Therapeutics N.V. was incorporated in 2012 and is headquartered in Leiden, the Netherlands.

How the Company Makes Money

ProQR generates revenue primarily through a combination of product sales, research and development collaborations, and licensing agreements. The company partners with pharmaceutical companies and research institutions to co-develop therapies, which can provide upfront payments, milestone payments, and royalties on future sales of products developed through these collaborations. Additionally, ProQR may receive funding through grants and investments aimed at advancing its clinical programs. As its drug candidates progress through clinical trials and gain regulatory approvals, the potential for revenue increases significantly, particularly if successful therapies are commercialized.

ProQR Financial Statement Overview

Summary

ProQR faces significant financial challenges, particularly in terms of profitability and cash flow generation. Despite a strong gross profit margin and manageable debt, negative net income and cash flow issues pose risks. The biotechnology sector's inherent volatility adds to the financial instability.

Income Statement

ProQR's income statement reveals significant challenges with profitability. The company has consistently reported negative net profit margins, with the TTM (Trailing-Twelve-Months) net profit margin at -240.63%. Revenue growth has been negative recently, indicating declining sales. The EBIT and EBITDA margins are also negative, reflecting operational inefficiencies. Despite these challenges, the gross profit margin remains high at 100%, suggesting that the company can cover its cost of goods sold effectively.

Balance Sheet

The balance sheet shows a moderate debt-to-equity ratio of 0.25 in the TTM period, indicating a manageable level of debt relative to equity. However, the return on equity is negative, reflecting ongoing losses. The equity ratio is not explicitly calculated, but the company's equity position appears stable relative to its assets, suggesting some financial stability despite profitability issues.

Cash Flow

ProQR's cash flow statement highlights challenges in generating positive cash flow. The operating cash flow and free cash flow are both negative, although there has been some improvement in free cash flow growth. The operating cash flow to net income ratio is negative, indicating cash flow issues relative to net income. However, the free cash flow to net income ratio is slightly above 1, suggesting that free cash flow is somewhat aligned with net income.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	15.56M	18.91M	6.51M	3.59M	1.33M	1.03M
Gross Profit	15.56M	18.91M	6.51M	3.59M	1.33M	1.03M
EBITDA	-37.87M	-24.12M	-24.10M	-56.46M	-54.95M	-48.44M
Net Income	-42.57M	-27.76M	-28.12M	-64.42M	-60.74M	-46.56M
Balance Sheet
Total Assets	124.35M	167.96M	137.88M	171.32M	209.58M	98.73M
Cash, Cash Equivalents and Short-Term Investments	106.88M	149.41M	118.92M	94.78M	187.52M	75.84M
Total Debt	16.49M	17.22M	19.73M	21.97M	60.37M	34.28M
Total Liabilities	67.28M	79.40M	96.49M	104.64M	96.35M	42.18M
Stockholders Equity	57.07M	88.56M	41.39M	67.06M	113.83M	57.09M
Cash Flow
Free Cash Flow	-49.41M	-37.81M	20.18M	-69.22M	-26.50M	-47.98M
Operating Cash Flow	-48.78M	-36.39M	21.55M	-68.51M	-26.01M	-47.06M
Investing Cash Flow	-3.28M	-4.07M	4.28M	-702.00K	-425.00K	-924.00K
Financing Cash Flow	70.19M	70.28M	-2.27M	-30.89M	136.83M	14.50M

ProQR Technical Analysis

• Technical Analysis Sentiment: Negative
• Last Price: 2.17
• 50DMA: Negative
• 100DMA: Negative
• 200DMA: Positive
• MACD: Positive
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PRQR, the sentiment is Negative. The current price of 2.17 is below the 20-day moving average (MA) of 2.54, below the 50-day MA of 2.38, and above the 200-day MA of 2.03, indicating a neutral trend. The MACD of -0.10 indicates Positive momentum. The RSI at 37.59 is Neutral, neither overbought nor oversold. The STOCH value of 24.88 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for PRQR.

ProQR Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
Sector *	51 Neutral	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
OABI	51 Neutral	$213.05M	-2.44	-22.37%	―	3.36%	5.15%
AVIR	47 Neutral	$259.50M	―	-37.98%	―	―	14.33%
CDXS	42 Neutral	$195.88M	-2.64	-114.26%	―	-17.87%	14.42%
HRTX	42 Neutral	$208.98M	-115.15	―	―	12.60%	58.23%
PRQR	41 Neutral	$250.41M	-5.36	-99.45%	―	-11.99%	-42.04%

ProQR Corporate Events

ProQR Reports Q3 2025 Financial Results Amid Revenue Decline

ProQR Therapeutics N.V. announced its financial results for the third quarter and the nine-month period ending September 30, 2025. The company reported a decrease in revenue compared to the previous year, with €2,882,000 for the quarter and €11,218,000 for the nine-month period. Operating costs increased, leading to a higher operating loss of €11,284,000 for the quarter and €34,349,000 for the nine months. The results reflect ongoing challenges in the biotechnology sector, impacting ProQR’s financial performance and highlighting the need for strategic adjustments to improve profitability.

ProQR Advances AX-0810 into Clinical Trials for Cholestatic Diseases

On November 3, 2025, ProQR Therapeutics hosted a virtual analyst and investor event to discuss its lead pipeline program, AX-0810, which is entering a first-in-human clinical trial targeting NTCP in cholestatic diseases. The event highlighted the company’s strategic overview and corporate outlook, emphasizing the establishment of safety, pharmacokinetics, and a biomarker roadmap for proof of target engagement. This development positions ProQR at the forefront of RNA editing medicines, particularly in neurological applications, and underscores its commitment to addressing unmet medical needs in various diseases.

ProQR Receives CTA Authorization for AX-0810 and Plans Investor Event

On October 20, 2025, ProQR Therapeutics announced that it received Clinical Trial Application (CTA) authorization from the Central Committee on Research Involving Human Subjects (CCMO) for a Phase 1 study of its investigational RNA editing oligonucleotide, AX-0810. This study, to be conducted in the Netherlands, will evaluate the safety, tolerability, and pharmacokinetics of AX-0810, which targets NTCP for the treatment of cholestatic diseases. The company also announced a virtual Investor and Analyst Event scheduled for November 3, 2025, to discuss the clinical development of AX-0810 and its potential impact on treating liver diseases.