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Predictive Oncology Inc (POAI)
NASDAQ:POAI

Predictive Oncology (POAI) AI Stock Analysis

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POAI

Predictive Oncology

(NASDAQ:POAI)

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Neutral 47 (OpenAI - 4o)
Rating:47Neutral
Price Target:
$6.00
▲(0.84% Upside)
The overall stock score is primarily impacted by the company's poor financial performance and valuation, reflecting significant operational and financial challenges. However, positive corporate events, including strategic rebranding and compliance achievements, provide some optimism for future growth potential.
Positive Factors
Strategic Rebranding
The rebranding to Axe Compute Inc. reflects a strategic shift towards AI infrastructure, potentially enhancing market positioning and growth.
Nasdaq Compliance
Regaining Nasdaq compliance strengthens financial credibility and ensures continued access to capital markets, supporting long-term growth.
Digital Asset Strategy
The digital asset strategy aligns with AI trends, potentially creating new revenue streams and enhancing competitive advantage in AI infrastructure.
Negative Factors
Declining Revenue
Declining revenue indicates challenges in market penetration and product adoption, potentially impacting long-term financial stability.
Negative Profit Margins
Decreasing profit margins suggest operational inefficiencies, which could limit the company's ability to invest in growth and innovation.
Financial Instability
Negative equity raises concerns about solvency and financial health, potentially limiting strategic flexibility and investment capacity.

Predictive Oncology (POAI) vs. SPDR S&P 500 ETF (SPY)

Predictive Oncology Business Overview & Revenue Model

Company DescriptionPredictive Oncology (POAI) is a biotechnology company focused on advancing personalized medicine through the use of artificial intelligence and data analytics. The company operates primarily in the healthcare sector, specializing in the development of predictive models that help predict patient responses to cancer treatments. Their core products include a proprietary platform that analyzes tumor samples and treatment data to optimize therapeutic strategies tailored to individual patients.
How the Company Makes MoneyPredictive Oncology generates revenue through a combination of research collaborations, licensing agreements, and direct service offerings. Key revenue streams include partnerships with pharmaceutical companies and research institutions that utilize POAI's technology for drug development and clinical trials. The company also earns income by providing laboratory services for analyzing tumor samples and conducting predictive modeling. Additionally, strategic alliances with healthcare providers and participation in industry consortia further enhance its revenue potential by expanding the application of its predictive analytics in cancer treatment.

Predictive Oncology Earnings Call Summary

Earnings Call Date:Aug 14, 2024
(Q2-2024)
|
% Change Since: |
Next Earnings Date:Apr 08, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted significant advancements in AI-driven biomarker discovery, strategic partnerships, and cost reduction initiatives, despite a decline in quarterly revenue and consolidation of non-profitable operations.
Q2-2024 Updates
Positive Updates
Successful Retrospective Ovarian Cancer Study
Completion of a multiyear ovarian cancer study with UPMC Magee-Womens Hospital, expanding AI capabilities to discover novel biomarkers for oncology.
Launch of 3D Cell Culture Technology
Introduction of a novel 3D cell culture technology that mimics human tissue architecture more closely, enhancing drug candidate testing and reducing development costs.
ACE Initiative and Collaboration
First collaboration with the University of Michigan under the ACE program, providing access to a large library of natural product drug candidates.
Cost Reduction Initiative
Strategic cost reduction measures, including consolidation of operations from Birmingham to Pittsburgh, expected to reduce annual cash usage by $2.5 million.
Capital Raises
Raised $5.0 million through capital raises to bolster cash balance and extend runway.
Negative Updates
Revenue Decline
Decrease in revenue to $279,000 for Q2 2024 from $490,000 in Q2 2023, primarily from the Egan operating segment.
Birmingham Operations Consolidation
Consolidation of Birmingham operations due to lack of profitability, with the segment generating a net loss of $2.0 million in 2023.
Cash and Equity Reduction
Reduction in cash and cash equivalents to $5.3 million and stockholders' equity to $4.1 million as of June 30, 2024, compared to $8.7 million and $8.3 million respectively as of December 31, 2023.
Company Guidance
During the Predictive Oncology Second Quarter 2024 Earnings Call, the company provided guidance on several strategic initiatives and financial metrics. Key highlights included the completion of a multiyear ovarian cancer study, which utilized data from 235 patients and resulted in the training of 160 predictive models with high accuracy. The company also launched a novel 3D cell culture technology and reported progress in its ACE initiative, forming a collaboration with the University of Michigan. Financially, Predictive Oncology reported a net loss of $3.2 million for the quarter, with a revenue of $279,000, compared to $490,000 in the previous year. They highlighted a strategic cost reduction initiative expected to save approximately $2.5 million annually, and capital raises totaling $5.0 million to bolster their cash position.

Predictive Oncology Financial Statement Overview

Summary
Predictive Oncology faces significant financial challenges with declining revenues, negative profit margins, and deteriorating liquidity and solvency metrics. The company must address operational inefficiencies and stabilize its financial position.
Income Statement
35
Negative
The company shows a declining revenue trend with a negative revenue growth rate over the years. Gross profit margin has decreased from 64.7% in 2023 to 49.1% in 2024. The net profit margin is severely low due to net losses. EBIT and EBITDA margins are negative, indicating operational inefficiencies.
Balance Sheet
25
Negative
The balance sheet reveals financial instability with a negative stockholders' equity in 2024, indicating potential solvency issues. Debt-to-equity ratio is not applicable due to negative equity. The equity ratio is negative, reflecting a concerning capital structure.
Cash Flow
40
Negative
Operating cash flows remain negative, highlighting ongoing liquidity challenges. Free cash flow is also negative, but there is a slight improvement in free cash flow growth rate from 2023 to 2024. The operating cash flow to net income ratio is negative, indicating inefficiencies in converting income to cash.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue728.20K1.62M1.63M1.51M1.42M1.25M
Gross Profit365.87K797.68K1.02M1.00M933.66K805.08K
EBITDA-83.09M-10.24M-11.87M-13.95M-12.13M-11.46M
Net Income-84.33M-12.20M-13.98M-25.74M-19.66M-25.88M
Balance Sheet
Total Assets3.14M4.97M14.42M25.73M43.77M13.06M
Cash, Cash Equivalents and Short-Term Investments181.67K734.67K8.73M22.07M28.20M678.33K
Total Debt1.70M2.13M2.73M180.32K879.33K5.87M
Total Liabilities80.57M5.18M6.15M3.97M3.51M10.42M
Stockholders Equity-77.43M-202.61K8.27M21.77M40.27M2.64M
Cash Flow
Free Cash Flow-8.78M-11.97M-13.21M-12.85M-13.17M-12.62M
Operating Cash Flow-8.78M-11.96M-13.19M-12.37M-12.21M-12.26M
Investing Cash Flow657.00K22.49K-302.37K-475.70K-10.61M-167.46K
Financing Cash Flow4.36M3.94M148.90K6.72M50.34M12.95M

Predictive Oncology Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price5.95
Price Trends
50DMA
8.25
Negative
100DMA
10.89
Negative
200DMA
13.19
Negative
Market Momentum
MACD
-0.68
Negative
RSI
44.69
Neutral
STOCH
86.92
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For POAI, the sentiment is Neutral. The current price of 5.95 is above the 20-day moving average (MA) of 5.80, below the 50-day MA of 8.25, and below the 200-day MA of 13.19, indicating a neutral trend. The MACD of -0.68 indicates Negative momentum. The RSI at 44.69 is Neutral, neither overbought nor oversold. The STOCH value of 86.92 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for POAI.

Predictive Oncology Risk Analysis

Predictive Oncology disclosed 41 risk factors in its most recent earnings report. Predictive Oncology reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Predictive Oncology Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
58
Neutral
$7.02M40.955.90%-4.99%-19.10%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
$53.80M-376.23%63.53%12.49%
47
Neutral
$14.46M-0.04-47.20%-163.70%
44
Neutral
$17.40M-0.92-85.01%-16.59%43.20%
41
Neutral
$3.78M
28
Underperform
$5.54M>-0.0160.83%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
POAI
Predictive Oncology
5.95
-5.30
-47.11%
EKSO
EKSO BIONICS
4.67
-4.93
-51.35%
GCTK
GlucoTrack
5.73
-302.67
-98.14%
FEMY
Femasys
0.86
-0.29
-25.57%
MHUA
Meihua International Medical Technologies Co., Ltd.
6.76
-42.60
-86.30%
WOK
WORK Medical Technology Group LTD
0.11
-508.89
-99.98%

Predictive Oncology Corporate Events

Delistings and Listing ChangesExecutive/Board ChangesBusiness Operations and Strategy
Predictive Oncology Rebrands to Axe Compute Inc. on Nasdaq
Positive
Dec 12, 2025

On December 10, 2025, Axe Compute Inc. amended the employment agreement with CEO Raymond F. Vennare, increasing his salary and outlining bonus eligibility. On December 12, 2025, the company announced its name change to Axe Compute Inc. and began trading on Nasdaq under the ticker AGPU. The company plans to expand its operations into high-performance AI infrastructure, positioning itself as a key player in addressing the infrastructure bottleneck in AI development by utilizing the Aethir network to provide scalable GPU capacity.

Delistings and Listing ChangesBusiness Operations and Strategy
Predictive Oncology Rebrands to Axe Compute Inc.
Neutral
Dec 11, 2025

Predictive Oncology Inc., a company involved in the field of oncology, has announced a corporate name change to Axe Compute Inc., effective December 11, 2025. This change, approved by the Board of Directors, does not require stockholder approval and involves the adoption of amended bylaws. The company’s stock will trade under the new ticker symbol ‘AGPU’ on Nasdaq starting December 12, 2025, with no changes to the CUSIP number or the validity of existing stock certificates.

Delistings and Listing ChangesRegulatory Filings and Compliance
Predictive Oncology Regains Nasdaq Compliance
Positive
Dec 2, 2025

On December 1, 2025, Predictive Oncology Inc. announced that it had regained compliance with Nasdaq’s minimum stockholders’ equity requirement, allowing its shares to continue trading on the Nasdaq Capital Market. This compliance reflects the company’s recent progress in strengthening its financial position and supports its long-term vision, including its digital asset strategy focused on the Aethir ecosystem. The company will be monitored by Nasdaq for a year, and any future non-compliance could lead to a delisting determination.

Executive/Board ChangesShareholder Meetings
Predictive Oncology Stockholders Approve Key Proposals
Neutral
Nov 25, 2025

At the Annual Meeting, Predictive Oncology‘s stockholders voted on several key proposals. The election of Class I directors, including Daniel E. Handley and Chuck Nuzum, was confirmed to serve until the 2028 Annual Meeting. Additionally, KPMG LLP’s appointment as the independent registered public accounting firm for the fiscal year ending December 31, 2025, was ratified. Stockholders also approved an amendment and the issuance of 14,903,393 shares upon the exercise of pre-funded warrants. Furthermore, a non-binding advisory vote approved the compensation of the company’s named executive officers.

Delistings and Listing ChangesPrivate Placements and FinancingRegulatory Filings and Compliance
Predictive Oncology Regains Nasdaq Compliance with Investments
Positive
Nov 20, 2025

Predictive Oncology Inc. has announced that it has regained compliance with Nasdaq’s minimum stockholders’ equity requirement following two private investment in public equity transactions. The company received approximately $343.5 million, which included cash and in-kind contributions of crypto assets, bringing its stockholders’ equity above the required $2.5 million threshold.

Business Operations and StrategyFinancial Disclosures
Predictive Oncology Unveils New Digital Asset Strategy
Positive
Nov 17, 2025

On November 17, 2025, Predictive Oncology Inc. held a conference call to discuss its third-quarter financial results and its new digital asset strategy. The company is aligning with the Aethir network to capitalize on the growing AI infrastructure market, projected to reach $2.8 trillion by 2029. This strategic move aims to enhance the company’s access to advanced computing power and create new revenue streams through digital assets, potentially impacting its market positioning and stakeholder value.

Private Placements and FinancingRegulatory Filings and Compliance
Predictive Oncology Updates ATM Offering Program
Neutral
Oct 29, 2025

On October 29, 2025, Predictive Oncology Inc. filed a prospectus supplement to update its at-the-market (ATM) offering program, allowing the sale of up to $18,330,000 in common stock. This move aims to adjust the maximum share sales under the ATM program, contingent on changes in the company’s public float, which could impact its ability to raise capital and expand its operations.

Shareholder Meetings
Predictive Oncology Schedules 2025 Annual Stockholder Meeting
Neutral
Oct 16, 2025

Predictive Oncology has scheduled its 2025 annual meeting of stockholders for November 25, 2025, at DLA Piper LLP’s offices in Pittsburgh, Pennsylvania. The company has set October 24, 2025, as the record date for determining stockholders eligible to vote. Stockholders have until October 26, 2025, to submit proposals for consideration at the meeting. The company plans to distribute proxy materials around November 3, 2025, and may adjust these materials or the meeting date based on proposals received.

Private Placements and FinancingBusiness Operations and Strategy
Predictive Oncology Closes $343.5M Private Placements
Positive
Oct 8, 2025

On October 8, 2025, Predictive Oncology announced the closing of two private placements totaling approximately $343.5 million, which occurred on October 7, 2025. The funds will support the company’s new digital asset treasury strategy focused on ATH, a utility token of the Aethir ecosystem. This initiative aligns with Predictive Oncology’s AI-driven drug discovery efforts and aims to enhance Aethir’s infrastructure for AI and machine learning globally. The strategic move is expected to create significant value for the company and its shareholders.

Executive/Board ChangesPrivate Placements and FinancingBusiness Operations and Strategy
Predictive Oncology Enters Securities Purchase Agreements
Positive
Sep 30, 2025

Predictive Oncology Inc., a Delaware corporation, announced on September 29, 2025, that it entered into securities purchase agreements with accredited investors for private placements involving cash and cryptocurrency offerings. The company plans to issue common stock and pre-funded warrants, with the proceeds primarily used to establish a cryptocurrency treasury strategy focusing on digital assets like Aethir tokens. This strategic move aims to enhance the company’s financial positioning and operational capabilities, while also initiating a digital asset treasury strategy to manage and acquire digital assets. Additionally, changes in the board of directors were announced, with Nancy Chung-Welch resigning and Shawn Matthews being appointed, reflecting the company’s strategic alignment with its new digital asset focus.

Private Placements and FinancingBusiness Operations and Strategy
Predictive Oncology Announces $344.4M Private Placements
Positive
Sep 29, 2025

On September 29, 2025, Predictive Oncology Inc. announced two private placements totaling $344.4 million to support its new digital asset treasury strategy, focusing on Aethir (ATH) tokens. This strategic move aims to enhance the company’s operations by leveraging Aethir’s decentralized GPU network, potentially strengthening its market position and offering significant growth opportunities. The company plans to use the proceeds to acquire ATH tokens and fund general corporate purposes, with DNA Holdings Venture, Inc. as a strategic advisor. This initiative marks a significant step in Predictive Oncology’s expansion into digital assets, aligning with its core business of AI-driven drug discovery.

Delistings and Listing ChangesStock Split
Predictive Oncology Announces Reverse Stock Split Approval
Neutral
Sep 25, 2025

On September 19, 2025, Predictive Oncology‘s stockholders approved a one-for-fifteen reverse stock split to comply with Nasdaq’s minimum bid price requirement. The reverse stock split, effective September 29, 2025, will reduce the number of outstanding shares and begin trading on a split-adjusted basis on September 30, 2025. This move aims to maintain the company’s listing on the Nasdaq Capital Market.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 13, 2025