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BiomX (PHGE)
:PHGE
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BiomX (PHGE) AI Stock Analysis

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PHGE

BiomX

(PHGE)

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Neutral 44 (OpenAI - 4o)
Rating:44Neutral
Price Target:
BiomX's overall score is driven by significant financial challenges, including negative revenues and high leverage, which are key risks. However, recent positive trial results and funding announcements provide potential for future growth and improvement.
Positive Factors
Positive Trial Results
The successful Phase 2 trial of BX211 demonstrates BiomX's potential in developing effective phage therapies, enhancing its competitive position in addressing serious bacterial infections.
New Funding
The $12M funding supports the Phase 2b study of BX004, strengthening BiomX's financial position and enabling continued development in the phage therapy market.
Product Development
BiomX's proprietary platform for developing phage therapies positions it well in the microbiome-focused biotech industry, providing a durable competitive advantage.
Negative Factors
Financial Challenges
Ongoing negative revenues and high operating losses indicate financial instability, potentially limiting BiomX's ability to sustain long-term operations without external funding.
High Leverage
High leverage and significant debt levels can restrict BiomX's financial flexibility and increase risk, impacting its ability to invest in growth opportunities.
Regulatory Hold
The FDA hold on BX004's trial, even if temporary, could delay product development timelines and affect BiomX's strategic plans in the cystic fibrosis treatment market.

BiomX (PHGE) vs. SPDR S&P 500 ETF (SPY)

BiomX Business Overview & Revenue Model

Company DescriptionBiomX Inc., a clinical-stage microbiome company, develops products using natural and engineered phage technologies designed to target and kill specific harmful bacteria. It targets bacteria that affect the appearance of skin, as well as chronic diseases, such as inflammatory bowel diseases (IBD), primary sclerosing cholangitis (PSC), cystic fibrosis (CF), atopic dermatitis, and colorectal cancer (CRC). It is developing BX004, a phage therapy for CF patients with chronic Pseudomonas aeruginosa respiratory infections that is in Phase 1b/2a clinical trials. The company's pipeline products also include BX005, a topical phage cocktail, which is in Phase 1/2 clinical study that targets Staphylococcus aureus (S. aureus), a bacteria associated with the manifestation of the disease; and BX003, an orally administered phage cocktail, which is in Phase 1b/2a that targets a bacterial target present in the gut of IBD and PSC patients. In addition, the company engages in the provision of colorectal cancer program that utilizes engineered phage with various payloads, which are administered intravenously to target Fusobacterium nucleatum bacteria residing within the tumor microenvironment. BiomX Inc. was founded in 2015 and is headquartered in Ness Ziona, Israel.
How the Company Makes MoneyBiomX primarily makes money through research and development collaborations, grants, and potential future product sales. The company engages in partnerships with pharmaceutical and biotechnology companies to co-develop phage therapies, which can provide upfront payments, milestone payments, and royalties. Additionally, BiomX may receive funding from governmental or non-profit grants to support its research initiatives. As its products progress through clinical trials and potentially reach the market, revenue from sales of approved therapies will become a significant source of income.

BiomX Earnings Call Summary

Earnings Call Date:Nov 12, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Apr 01, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted significant progress in clinical trials and positive regulatory feedback which provides a strong outlook for future developments. However, financial challenges and regulatory holds present ongoing risks. Optimism in phage therapy's future and strategic plans for BX011 and BX004 suggest a cautiously positive sentiment.
Q3-2025 Updates
Positive Updates
BX004 Phase IIb Trial Progress and FDA Feedback
The BX004 program for cystic fibrosis patients showed significant progress with first patient dosing in the Phase IIb trial. Despite a clinical hold on U.S. trial sites due to a third-party nebulizer device, the European trial continues uninterrupted. FDA feedback recognized the unmet need for treatments targeting chronic Pseudomonas aeruginosa infections and provided constructive guidance for development pathways, including Phase III criteria.
Positive FDA Feedback for BX011 in Diabetic Foot Infections
The FDA provided positive feedback on the development plan for BX011 targeting Staphylococcus aureus infections in diabetic foot infections (DFI). The program aims to provide an off-the-shelf formulation with potential for dual-use in combat-related wound infections, aligning with U.S. Defense Health Agency priorities. The FDA outlined a clear pathway toward a Biologics License Application without additional nonclinical studies, supporting the commercial opportunity.
Financial Management and Reduced Expenses
Research and development expenses decreased to $6.1 million in Q3 2025 from $7.3 million in Q3 2024, attributed to workforce reduction and lower rent expenses. General and administrative expenses also decreased to $2.4 million from $3.2 million. BiomX estimates its cash reserves are sufficient to fund operations into Q1 2026.
Negative Updates
Clinical Hold on BX004 U.S. Trial Sites
The FDA placed a clinical hold on BX004 U.S. trial sites due to concerns with a third-party nebulizer device, not the drug candidate itself. This temporary pause affects U.S. sites while awaiting further FDA feedback, although European enrollment continues as planned.
Decreased Cash Balance and Net Loss
Cash balance and restricted cash decreased to $8.1 million as of September 30, 2025, from $18 million at the end of 2024, mainly due to net cash used in operating activities. The net loss for Q3 2025 was $9.2 million, compared to a net income of $9.6 million in Q3 2024, influenced by changes in the fair value of warrants.
Company Guidance
During the BiomX Third Quarter 2025 Financial Results and Program Update Conference Call, the company provided guidance on several metrics. BiomX reported a cash balance of $8.1 million as of September 30, 2025, with expectations that this would fund operations into the first quarter of 2026. Research and development expenses decreased to $6.1 million from $7.3 million in the same quarter of 2024, largely due to workforce reductions and lower rent expenses. The company also noted a net loss of $9.2 million for the quarter, compared to a net income of $9.6 million the previous year, primarily due to changes in the fair value of warrants from its March 2024 financing. Additionally, BiomX is advancing its lead programs, BX004 and BX011, with regulatory engagement and clinical trial progress, despite a temporary FDA clinical hold on BX004 due to a third-party nebulizer device. They expect to report BX004 Phase IIb data in Q1 2026 and have received positive FDA feedback for BX011's development pathway.

BiomX Financial Statement Overview

Summary
BiomX faces significant financial challenges with persistent negative revenues and high operating losses. The balance sheet shows high leverage, and the cash flow statements indicate a reliance on external financing. Despite some improvements in net income and stockholders' equity, the company's overall financial health is strained.
Income Statement
15
Very Negative
BiomX has consistently reported negative revenues and gross profit over the years, indicating significant challenges in generating income. The company has also faced substantial net losses, although a notable improvement in net income was seen in 2024. The lack of revenue growth and negative margins, such as EBIT and EBITDA, highlight ongoing difficulties in achieving profitability.
Balance Sheet
35
Negative
The company's balance sheet shows high leverage, with a significant amount of total debt relative to equity, resulting in a concerning debt-to-equity ratio. However, the equity ratio indicates that a reasonable portion of the company's assets are financed by equity. Despite recent improvements in stockholders' equity, the overall financial stability remains a concern due to the high liabilities.
Cash Flow
25
Negative
BiomX's cash flow statements reflect ongoing negative free cash flow, indicating cash outflows from operations and investments. While there is a trend of securing financing to support cash needs, this reliance on external funding poses risks. The operating cash flow to net income ratio shows significant cash outflows relative to earnings, underscoring financial pressure.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.000.000.000.00
Gross Profit-292.00K-1.80M-871.00K0.000.000.00
EBITDA-29.88M-13.13M-22.82M-23.66M-32.90M-29.60M
Net Income-37.38M-17.73M-26.17M-28.32M-36.23M-30.09M
Balance Sheet
Total Assets26.17M43.23M25.03M45.53M77.99M70.36M
Cash, Cash Equivalents and Short-Term Investments7.91M17.81M14.91M33.33M62.10M56.33M
Total Debt6.58M9.58M15.09M19.36M20.02M5.89M
Total Liabilities15.68M19.09M21.95M24.49M30.45M12.89M
Stockholders Equity10.49M24.15M3.08M21.04M47.53M57.47M
Cash Flow
Free Cash Flow-28.31M-37.01M-21.34M-29.20M-31.25M-25.46M
Operating Cash Flow-28.29M-36.98M-21.29M-29.09M-27.57M-24.45M
Investing Cash Flow106.00K715.00K1.95M-2.11M16.17M-10.86M
Financing Cash Flow11.54M38.37M2.90M292.00K37.28M134.00K

BiomX Technical Analysis

Technical Analysis Sentiment
Negative
Last Price4.36
Price Trends
50DMA
9.03
Negative
100DMA
9.12
Negative
200DMA
10.02
Negative
Market Momentum
MACD
-1.31
Positive
RSI
26.70
Positive
STOCH
17.84
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PHGE, the sentiment is Negative. The current price of 4.36 is below the 20-day moving average (MA) of 6.59, below the 50-day MA of 9.03, and below the 200-day MA of 10.02, indicating a bearish trend. The MACD of -1.31 indicates Positive momentum. The RSI at 26.70 is Positive, neither overbought nor oversold. The STOCH value of 17.84 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for PHGE.

BiomX Risk Analysis

BiomX disclosed 72 risk factors in its most recent earnings report. BiomX reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

BiomX Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
44
Neutral
$6.66M-0.14-154.50%54.25%
43
Neutral
$19.10M-32.92%-44.31%-34.17%
42
Neutral
$15.60M
41
Neutral
-1341.37%-53.61%-93.14%
38
Underperform
$13.59M-2.96-49.00%47.17%26.84%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
PHGE
BiomX
4.36
-9.51
-68.57%
CANF
Can-Fite BioPharma
0.35
-1.82
-83.87%
LPCN
Lipocine
3.44
-0.86
-20.00%
ADAP
Adaptimmune Therapeutics
0.04
-0.68
-94.44%
IMRN
Immuron
1.71
-0.26
-13.20%
OSRH
OSR Holdings
0.74
-10.48
-93.40%

BiomX Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
BiomX Announces Positive Phase 2 Trial Results
Positive
Mar 31, 2025

On March 31, 2025, BiomX Inc. announced positive results from its Phase 2 trial of BX211 for treating Diabetic Foot Osteomyelitis (DFO) associated with Staphylococcus aureus. The trial demonstrated that BX211 was safe, well-tolerated, and produced statistically significant reductions in ulcer size and depth compared to placebo. These findings highlight the potential of phage therapy in addressing serious bacterial infections and reducing the need for amputations in diabetic patients. Following these results, BiomX plans to proceed with a Phase 2/3 trial pending FDA feedback.

Private Placements and FinancingBusiness Operations and Strategy
BiomX Announces $12M Funding for BX004 Study
Positive
Feb 27, 2025

On February 25, 2025, BiomX Inc. announced a securities purchase agreement involving a registered direct offering and concurrent private placement, expected to generate approximately $12 million in gross proceeds. The funds will support the Phase 2b clinical study of BX004, a phage cocktail for treating cystic fibrosis patients with chronic Pseudomonas aeruginosa infections, with results anticipated in Q1 2026. The offerings, led by Deerfield Management Company and the Cystic Fibrosis Foundation, are set to close around February 27, 2025, and include a reduction in exercise price for existing warrants. This strategic move aims to advance BiomX’s clinical programs and strengthen its position in the phage therapy market.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: May 02, 2025