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Curis Inc. (CRIS)
:CRIS

Curis (CRIS) AI Stock Analysis

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Curis

(NASDAQ:CRIS)

Rating:39Underperform
Price Target:
$1.50
▼(-14.29%Downside)
Curis' overall stock score is primarily impacted by its financial instability, with persistent losses and negative cash flows posing significant risks. The bearish technical indicators further weigh on the score. While clinical trial progress offers potential, the immediate financial challenges overshadow these developments.
Positive Factors
Drug Development
Emavusertib is the only IRAK4 inhibitor in late-stage clinical development, positioning it uniquely in a crowded market.
Regulatory Support
Curis has received a positive regulatory foundation from both FDA and EMA, enhancing its potential market success.
Negative Factors
Enrollment Challenges
The primary challenge is the difficulty of enrollment, given the small patient population.
Stock Valuation
The price target is being lowered due to dilution from a recent raise, which could impact the stock's valuation.

Curis (CRIS) vs. SPDR S&P 500 ETF (SPY)

Curis Business Overview & Revenue Model

Company DescriptionCuris, Inc., a biotechnology company, engages in the discovery and development of drug candidates for the treatment of human cancers in the United States. Its clinical stage drug candidates include Emavusertib, an oral small molecule drug candidate, which is in a Phase 1/2 clinical trial for the treatment of non-hodgkin lymphomas, and acute myeloid leukemia and myelodysplastic syndromes; and CI-8993, a monoclonal antibody designed to antagonize the V-domain Ig suppressor of T cell activation. The company's pipeline also includes Fimepinostat, an oral dual inhibitor of HDAC and PI3K enzymes for the treatment of patients with MYC-altered diffuse large B-cell lymphoma; CA-170, an oral small molecule drug candidate for treating patients with advanced solid tumors and lymphomas; and CA-327, a pre-investigational new drug stage oncology drug candidate. It has collaboration agreement with F. Hoffmann-La Roche Ltd. and Genentech Inc. for the development and commercialization of Erivedge, an orally-administered small molecule hedgehog signaling pathway inhibitor for the treatment of advanced basal cell carcinoma; and with Aurigene Discovery Technologies Limited for the discovery, development, and commercialization of small molecule compounds in the areas of immuno-oncology and precision oncology. Curis, Inc. was incorporated in 2000 and is headquartered in Lexington, Massachusetts.
How the Company Makes MoneyCuris primarily makes money through the development and commercialization of cancer treatments, with revenue generated from product sales, licensing agreements, and strategic partnerships. The company enters into collaboration agreements with other pharmaceutical companies, which may include upfront payments, milestone payments, and royalties based on the successful development and commercialization of their drug candidates. Additionally, Curis may receive research funding from partners to support its ongoing research and development efforts.

Curis Earnings Call Summary

Earnings Call Date:May 06, 2025
(Q1-2025)
|
% Change Since: -28.57%|
Next Earnings Date:Jul 31, 2025
Earnings Call Sentiment Positive
The earnings call highlighted significant progress in clinical trials, especially with emavusertib in PCNSL and AML, showing strong potential for future growth. Financial performance improved, though there is a concern about the limited cash runway. Overall, the positive developments in clinical trials outweigh the financial concerns.
Q1-2025 Updates
Positive Updates
Strong Progress in PCNSL Study
The TakeAim lymphoma study evaluating emavusertib in combination with ibrutinib showed promising results with 9 out of 13 BTKI-experienced patients showing tumor reduction. The study is on track to support accelerated submissions in both the U.S. and Europe.
Significant Improvement Over Existing Treatments in AML
Emavusertib showed a 38% composite CR rate in a study with relapsed/refractory AML patients, which is a significant improvement over gilteritinib's 21% CR rate, highlighting emavusertib's novel mechanism of action.
Successful Financial Management
Curis reported a decreased net loss of $10.6 million compared to $11.9 million last year and completed a registered direct financing with net proceeds of $8.8 million.
Negative Updates
Limited Cash Runway
Curis' cash and cash equivalents are expected to fund operations only until the fourth quarter of 2025, indicating a potential need for additional funding in the near term.
Company Guidance
During Curis' first quarter 2025 business update call, the company provided several key metrics and updates on their ongoing efforts. In their TakeAim lymphoma study, which evaluates emavusertib in combination with ibrutinib for primary CNS lymphoma (PCNSL), 27 patients with relapsed/refractory PCNSL have been treated, including 7 BTKI-naive patients and 20 BTKI-experienced patients. Among the BTKI-experienced group, 6 out of 13 response-evaluable patients demonstrated a reduction in tumor burden, with 4 achieving complete responses, 3 of which lasted over 6 months. In the BTKI-naive group, all 5 evaluable patients showed objective responses. Additionally, Curis reported a net loss of $10.6 million for the first quarter, with cash and cash equivalents totaling $20.3 million as of March 31, 2025, expected to fund operations into the fourth quarter of 2025. The company continues to focus on enrolling 30 to 40 additional patients for their NDA submission and is planning further data releases at the upcoming ASH conference.

Curis Financial Statement Overview

Summary
Curis faces significant financial challenges with persistent losses and negative cash flows. Revenue growth is evident, but the company struggles with profitability and a fragile balance sheet, indicated by negative equity and ongoing operational losses.
Income Statement
45
Neutral
Curis shows a slight increase in revenue from the previous year, but the company still suffers from significant negative net income and EBIT margins, indicating ongoing profitability issues. The gross profit margin remains positive, but the net profit margin is deeply negative, reflecting operational challenges.
Balance Sheet
30
Negative
The balance sheet reveals a negative stockholders' equity, which is concerning, indicating that liabilities exceed assets. The debt-to-equity ratio is not calculable due to negative equity. This highlights potential solvency issues and financial instability.
Cash Flow
40
Negative
Curis has negative free cash flow and operating cash flow, which are troubling. The cash flow from operations is consistently negative, which may indicate difficulties in generating cash from core activities. Despite some improvement in cash flow from investing activities, the overall cash flow position remains weak.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue11.20M10.91M10.02M10.16M10.65M10.84M
Gross Profit11.12M10.81M9.81M9.90M10.12M10.30M
EBITDA-41.87M-42.57M-45.14M-50.51M-39.98M-24.67M
Net Income-42.13M-43.39M-47.41M-60.32M-50.64M-34.88M
Balance Sheet
Total Assets39.33M41.27M77.28M108.85M162.30M204.36M
Cash, Cash Equivalents and Short-Term Investments20.28M20.00M56.33M85.62M139.85M183.06M
Total Debt2.64M2.95M2.79M6.74M5.04M7.66M
Total Liabilities45.93M47.26M57.61M62.30M71.59M73.69M
Stockholders Equity-6.61M-6.00M19.67M46.55M90.71M130.67M
Cash Flow
Free Cash Flow-33.58M-39.56M-38.43M-54.75M-37.62M-26.42M
Operating Cash Flow-33.58M-39.56M-38.43M-54.34M-37.62M-25.74M
Investing Cash Flow10.53M29.44M37.79M33.02M-47.90M-49.05M
Financing Cash Flow13.38M3.44M7.58M867.00K-4.17M188.81M

Curis Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.75
Price Trends
50DMA
2.16
Negative
100DMA
2.29
Negative
200DMA
3.27
Negative
Market Momentum
MACD
-0.04
Positive
RSI
34.37
Neutral
STOCH
28.34
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CRIS, the sentiment is Negative. The current price of 1.75 is below the 20-day moving average (MA) of 2.33, below the 50-day MA of 2.16, and below the 200-day MA of 3.27, indicating a bearish trend. The MACD of -0.04 indicates Positive momentum. The RSI at 34.37 is Neutral, neither overbought nor oversold. The STOCH value of 28.34 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for CRIS.

Curis Risk Analysis

Curis disclosed 61 risk factors in its most recent earnings report. Curis reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Curis Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
53
Neutral
$22.56M-450.47%9.47%81.37%
51
Neutral
$7.50B0.32-61.87%2.27%17.10%1.59%
43
Neutral
$24.59M-56.49%7.07%
39
Underperform
$18.31M-2951.24%14.17%28.26%
35
Underperform
$23.23M-246.21%44.38%
UBUBX
31
Underperform
$5.13M-231.27%35.08%
CVCVM
27
Underperform
$12.94M-238.64%30.96%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CRIS
Curis
1.75
-4.63
-72.57%
CVM
Cel-Sci
2.52
-33.78
-93.06%
LSTA
Lisata Therapeutics
2.73
-0.78
-22.22%
UBX
Unity Biotechnology
0.30
-1.01
-77.10%
VVOS
Vivos Therapeutics
3.83
1.53
66.52%
BCAB
BioAtla
0.40
-0.92
-69.70%

Curis Corporate Events

Private Placements and Financing
Curis Announces $7M Securities Purchase Agreement
Neutral
Jul 2, 2025

On July 2, 2025, Curis, Inc. announced a securities purchase agreement with institutional investors to raise approximately $7 million through a combination of registered direct offerings and private placements. This financial move is expected to support the company’s operations into the first quarter of 2026, providing a cash runway to advance its research and development programs. The agreement includes the issuance of common stock and warrants, with the offerings anticipated to close by July 3, 2025, subject to customary conditions. The company has engaged Laidlaw & Company and JonesTrading Institutional Services as co-placement agents for the transaction.

The most recent analyst rating on (CRIS) stock is a Buy with a $26.00 price target. To see the full list of analyst forecasts on Curis stock, see the CRIS Stock Forecast page.

Shareholder MeetingsBusiness Operations and Strategy
Curis Approves Key Amendments at Annual Meeting
Neutral
May 22, 2025

On May 20, 2025, Curis, Inc. held its Annual Meeting of Stockholders virtually, where several key amendments were approved. The stockholders approved an amendment to the company’s stock incentive plan to reserve an additional 1,255,000 shares of common stock, increasing the total authorized shares for issuance. Additionally, an amendment to the company’s Restated Certificate of Incorporation was adopted, increasing the number of authorized shares of capital stock and common stock significantly. The board also approved changes to the company’s bylaws, reducing the quorum requirement for stockholder meetings. These changes aim to enhance the company’s operational flexibility and shareholder engagement.

The most recent analyst rating on (CRIS) stock is a Buy with a $26.00 price target. To see the full list of analyst forecasts on Curis stock, see the CRIS Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 03, 2025