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Curis Inc (CRIS)
NASDAQ:CRIS
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Curis (CRIS) AI Stock Analysis

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CRIS

Curis

(NASDAQ:CRIS)

Rating:42Neutral
Price Target:
$1.50
▼(-10.71% Downside)
Curis' overall stock score is primarily impacted by its weak financial performance and valuation metrics. The company's ongoing financial challenges, including negative equity and cash flow issues, are significant concerns. Technical analysis also indicates bearish momentum. While there are positive developments in clinical trials, the limited cash runway and regulatory uncertainties add to the risk. The Nasdaq delisting notice further exacerbates the situation, highlighting the company's precarious market position.
Positive Factors
Clinical Development
The company remains focused on advancing its lead asset, emavusertib, a potential first-in-class oral, small molecule inhibitor of IRAK4, through clinical development.
Market Position
Emavusertib is the only IRAK4 inhibitor in late-stage clinical development, positioning it uniquely in a crowded market.
Regulatory Progress
Curis has received a positive regulatory foundation from both FDA and EMA, enhancing its potential market success.
Negative Factors
Clinical Trial Risks
Key risks include clinical trial failure, efficacy in limited patient types, and failure to expand the drug development pipeline.
Efficacy Data Expectations
In the AML program, safety studies aim to address any potential concerns associated with the triplet combination therapy, and meaningful efficacy data is not expected for at least 12 months.
Patient Enrollment Challenges
The primary challenge is the difficulty of enrollment, given the small patient population.

Curis (CRIS) vs. SPDR S&P 500 ETF (SPY)

Curis Business Overview & Revenue Model

Company DescriptionCuris, Inc. (CRIS) is a biotechnology company focused on the development of innovative medicines for the treatment of cancer. The company operates primarily in the biopharmaceutical sector, specializing in targeted therapies and immunotherapies designed to address specific cancer pathways. Curis's core products include its proprietary drug candidates, which are in various stages of clinical development, aimed at providing new treatment options for patients with severe unmet medical needs in oncology.
How the Company Makes MoneyCuris generates revenue primarily through the development and commercialization of its drug candidates. The company earns money through several key revenue streams, including milestone payments from partnerships with larger pharmaceutical companies, royalties on product sales, and potential licensing agreements for its proprietary technologies. Significant partnerships with larger biotech or pharmaceutical companies can provide upfront payments and additional funding contingent on the achievement of specific development milestones. Additionally, if any of Curis's products receive regulatory approval and reach the market, the company would benefit from sales revenue, contributing to its overall earnings.

Curis Earnings Call Summary

Earnings Call Date:Aug 05, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Nov 12, 2025
Earnings Call Sentiment Positive
The earnings call highlighted significant progress in clinical trials, particularly in the TakeAim Lymphoma study and AML research, alongside improved financial figures. However, concerns about the limited cash runway and an uncertain regulatory environment introduce caution.
Q2-2025 Updates
Positive Updates
Promising TakeAim Lymphoma Study Progress
The TakeAim Lymphoma study, evaluating emavusertib in combination with ibrutinib, is progressing well with expectations to support accelerated submissions in the U.S. and Europe after enrolling 30 to 40 additional patients.
Encouraging AML Study Results
The emavusertib study in relapsed/refractory AML showed a compelling 38% composite CR rate, significantly higher compared to gilteritinib's 21% in similar settings, indicating a promising novel mechanism of action.
Financial Improvement
Curis reported a net loss of $8.6 million for Q2 2025, a decrease from $11.8 million in Q2 2024, with reduced research and development as well as general and administrative expenses.
Negative Updates
Limited Cash Runway
Curis' cash and cash equivalents of $10.1 million as of June 30, 2025, are projected to fund operations only into the first quarter of 2026, necessitating further fundraising efforts.
Uncertainty in Regulatory Environment
Concerns were raised about the current era at FDA, which might affect the biotech industry, although it is not expected to significantly impact Curis' specific case.
Company Guidance
During Curis' Second Quarter 2025 Business Update Call, several guidance metrics were provided. The company plans to enroll 30 to 40 additional patients in the TakeAim Lymphoma study over the next 12 to 18 months, aiming for NDA and EMA submissions. They anticipate initiating a proof-of-concept study for relapsed/refractory CLL with around 20 to 30 patients by year-end, expecting initial data by mid-2026. In AML, they plan a registrational study comparing emavusertib to gilteritinib. Financially, Curis reported a net loss of $8.6 million for Q2 2025, a decrease from $11.8 million in Q2 2024, with cash and equivalents of $10.1 million as of June 30, 2025. They completed a registered direct offering and private placement with net proceeds of approximately $6 million, extending their cash runway into Q1 2026.

Curis Financial Statement Overview

Summary
Curis faces significant financial challenges with persistent losses and negative cash flows. The balance sheet reveals negative stockholders' equity, indicating potential solvency issues. Despite some revenue growth, the company's profitability and balance sheet stability are concerning.
Income Statement
45
Neutral
Curis shows a slight increase in revenue from the previous year, but the company still suffers from significant negative net income and EBIT margins, indicating ongoing profitability issues. The gross profit margin remains positive, but the net profit margin is deeply negative, reflecting operational challenges.
Balance Sheet
30
Negative
The balance sheet reveals a negative stockholders' equity, which is concerning, indicating that liabilities exceed assets. The debt-to-equity ratio is not calculable due to negative equity. This highlights potential solvency issues and financial instability.
Cash Flow
40
Negative
Curis has negative free cash flow and operating cash flow, which are troubling. The cash flow from operations is consistently negative, which may indicate difficulties in generating cash from core activities. Despite some improvement in cash flow from investing activities, the overall cash flow position remains weak.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue11.40M10.91M10.02M10.16M10.65M10.84M
Gross Profit11.32M10.81M9.81M9.90M10.12M10.30M
EBITDA-37.56M-42.57M-45.14M-50.51M-39.98M-24.67M
Net Income-38.92M-43.39M-47.41M-60.32M-50.64M-34.88M
Balance Sheet
Total Assets29.23M41.27M77.28M108.85M162.30M204.36M
Cash, Cash Equivalents and Short-Term Investments10.14M20.00M56.33M85.62M139.85M183.06M
Total Debt32.47M2.95M2.79M6.74M5.04M7.66M
Total Liabilities43.22M47.26M57.61M62.30M71.59M73.69M
Stockholders Equity-13.99M-6.00M19.67M46.55M90.71M130.67M
Cash Flow
Free Cash Flow-30.46M-39.56M-38.43M-54.75M-37.62M-26.42M
Operating Cash Flow-30.46M-39.56M-38.43M-54.34M-37.62M-25.74M
Investing Cash Flow17.89M29.44M37.79M33.02M-47.90M-49.05M
Financing Cash Flow12.71M3.44M7.58M867.00K-4.17M188.81M

Curis Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.68
Price Trends
50DMA
1.77
Negative
100DMA
1.92
Negative
200DMA
2.52
Negative
Market Momentum
MACD
-0.03
Negative
RSI
48.15
Neutral
STOCH
44.83
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CRIS, the sentiment is Negative. The current price of 1.68 is above the 20-day moving average (MA) of 1.67, below the 50-day MA of 1.77, and below the 200-day MA of 2.52, indicating a neutral trend. The MACD of -0.03 indicates Negative momentum. The RSI at 48.15 is Neutral, neither overbought nor oversold. The STOCH value of 44.83 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for CRIS.

Curis Risk Analysis

Curis disclosed 61 risk factors in its most recent earnings report. Curis reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Curis Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
53
Neutral
$17.79M-83.85%-96.76%26.87%
51
Neutral
$7.95B-0.40-41.62%2.21%22.29%-1.85%
44
Neutral
$11.36M-503.80%60.64%
42
Neutral
$21.00M-2951.24%12.24%40.74%
38
Underperform
$15.94M-276.72%2.11%-87.50%92.82%
35
Underperform
$25.43M-66.12%154.52%47.84%
33
Underperform
47.73%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CRIS
Curis
1.68
-3.26
-65.99%
CYCC
Cyclacel Pharmaceuticals
7.12
-256.88
-97.30%
MBRX
Moleculin Biotech
0.38
-1.98
-83.90%
PULM
Pulmatrix
4.87
2.87
143.50%
ELEV
Elevation Oncology
0.36
-0.27
-42.86%
RLYB
Rallybio
0.61
-0.50
-45.05%

Curis Corporate Events

Delistings and Listing ChangesRegulatory Filings and Compliance
Curis Appeals Nasdaq Delisting Notice After Non-Compliance
Negative
Aug 22, 2025

On February 21, 2025, Curis, Inc. was notified by Nasdaq that it was not in compliance with the market value listing standard, as its securities’ market value had been below $35 million for 30 consecutive trading days. Despite a 180-day compliance period ending on August 20, 2025, Curis failed to meet the requirement and was informed on August 21, 2025, that its securities would be delisted unless it appealed the decision. Curis intends to request a hearing to appeal, which will temporarily halt the delisting process, but there is no guarantee of regaining compliance.

Private Placements and FinancingRegulatory Filings and Compliance
Curis Files Prospectus Supplement for Stock Offering
Neutral
Aug 8, 2025

On August 8, 2025, Curis, Inc. announced the filing of a prospectus supplement under its universal shelf registration statement with the SEC, allowing for the offer and sale of up to $8,137,047 of common stock. This move follows the company’s decision on July 1, 2025, to terminate a prior prospectus related to a larger offering, while maintaining the existing sales agreement with Cantor Fitzgerald & Co. and JonesTrading Institutional Services LLC. The legal opinion regarding the shares was provided by Wilmer Cutler Pickering Hale and Dorr LLP.

Private Placements and Financing
Curis Announces $7M Securities Purchase Agreement
Neutral
Jul 2, 2025

On July 2, 2025, Curis, Inc. announced a securities purchase agreement with institutional investors to raise approximately $7 million through a combination of registered direct offerings and private placements. This financial move is expected to support the company’s operations into the first quarter of 2026, providing a cash runway to advance its research and development programs. The agreement includes the issuance of common stock and warrants, with the offerings anticipated to close by July 3, 2025, subject to customary conditions. The company has engaged Laidlaw & Company and JonesTrading Institutional Services as co-placement agents for the transaction.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 26, 2025