Registrational Pathway for PCNSL with Regulatory Support
TakeAim Lymphoma (PCNSL) is a single-arm registrational study with an ORR endpoint; company reports collaborative discussions with FDA and EMA and expects the study to support accelerated submissions in the US and Europe. Enrollment is on track with an estimated 12–18 months to full enrollment and potential filing in 2027 after ~6 months of follow-up.
Encouraging AML Triplet Data (MRD Conversion)
At ASH, Curis presented early data from the AML triplet study (emavusertib + azacitidine + venetoclax): 5 of 8 evaluable patients achieved MRD conversion (62.5%), described as encouraging initial efficacy signal.
Progress into CLL with Proof-of-Concept Study
Company has initiated site activations in the US and Europe for a proof-of-concept study adding emavusertib to BTKi in CLL to deepen responses (aiming for CR/MRD negativity). Initial data are anticipated for the ASH Annual Meeting in December 2026.
Improved FY2025 Financial Result vs. FY2024
Full-year net loss narrowed to $7.6M in 2025 from $43.4M in 2024, an improvement of $35.8M (≈82.6% reduction in net loss year-over-year).
Q4 2025 Net Income Driven by One-Time Gain
Curis reported Q4 2025 net income of $19.4M ($1.23 per share) versus a Q4 2024 net loss of $9.6M; the Q4 2025 result reflects a $27.2M one-time non-cash gain from the sale of Erivedge to Oberland.
Lower Operating Expenses and Strengthened Cash Position
R&D and G&A costs declined: Q4 R&D down to $5.8M from $9.0M (≈35.6% decrease); full-year R&D down to $28.3M from $38.6M (≈26.7% decrease). Q4 G&A down to $2.9M from $3.4M (≈14.7% decrease); full-year G&A down to $14.0M from $16.8M (≈16.7% decrease). Cash and cash equivalents as of 12/31/2025 plus $20.2M received in Jan 2026 and up to an additional $20.2M from warrant exercise (contingent) are expected to fund planned operations into 2027.