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Neumora Therapeutics, Inc. (NMRA)
NASDAQ:NMRA
US Market
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Neumora Therapeutics, Inc. (NMRA) AI Stock Analysis

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NMRA

Neumora Therapeutics, Inc.

(NASDAQ:NMRA)

Rating:33Underperform
Price Target:
Neumora Therapeutics, Inc. is significantly challenged by its financial position, with ongoing losses and no revenue. Technical analysis indicates bearish momentum, and valuation is difficult in the absence of earnings. While promising pipeline advancements and a strong cash position offer some optimism, the overall outlook is hindered by recent clinical setbacks and financial instability.
Positive Factors
Market Reaction
NMRA's shares have increased significantly since the announcement of the new M4 PAM candidate, indicating market embrace of the news.
New Product Introduction
NMRA has introduced NMRA-861, a new M4 PAM candidate for schizophrenia and other neuropsychiatric disorders, which has advanced into the clinic.
Strategic Development
Neumora announced it will be prioritizing obesity as lead indication for NMRA-215, the company’s highly brain-penetrant NLRP3 inhibitor.
Negative Factors
Financial Constraints
Neumora may need to raise additional capital to fund the development of its pipeline, indicating potential financial challenges.
Historical Setbacks
The stock is still suffering from the fallout of first negative P3 KOASTAL-1 data for navacaprant in depression.
Regulatory Challenges
Risks include the regulatory challenge as none of Neumora's products has been approved by the FDA.

Neumora Therapeutics, Inc. (NMRA) vs. SPDR S&P 500 ETF (SPY)

Neumora Therapeutics, Inc. Business Overview & Revenue Model

Company DescriptionNeumora Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in developing therapeutic treatments for brain diseases, neuropsychiatric disorders, and neurodegenerative diseases. The company develops navacaprant (NMRA-140), a novel once-daily oral kappa opioid receptor antagonist, which is in phase 3 clinical trials for the treatment of major depressive disorder. It also develops NMRA-511 that is in phase 1 clinical trials in patients with agitation associated with dementia due to Alzheimer's disease; and NMRA-266, which is in the phase 1 clinical trial for the treatment of schizophrenia and other neuropsychiatric disorders. In addition, its preclinical phase product includes NMRA-NMDA for the treatment of schizophrenia; NMRA-CK1d, a CK1d inhibitor program for the treatment of amyotrophic lateral sclerosis; NMRA-NLRP3 for the treatment of certain neurodegenerative conditions; and NMRA-GCase for the treatment of Parkinson's disease. The company was formerly known as RBNC Therapeutics, Inc. and changed its name to Neumora Therapeutics, Inc. in October 2021. Neumora Therapeutics, Inc. was incorporated in 2019 and is headquartered in Watertown, Massachusetts.
How the Company Makes MoneyNeumora Therapeutics, Inc. generates revenue through the development and commercialization of its precision medicines. The company focuses on advancing its pipeline of investigational therapies through various stages of clinical trials, aiming for regulatory approval and subsequent market entry. Revenue is primarily derived from the successful commercialization of approved drugs. Additionally, Neumora may engage in strategic partnerships and collaborations with other pharmaceutical companies, which can include licensing agreements, joint ventures, or co-development arrangements, providing additional revenue streams and resources to support its research and development activities.

Neumora Therapeutics, Inc. Earnings Call Summary

Earnings Call Date:Aug 06, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Oct 29, 2025
Earnings Call Sentiment Positive
The earnings call reflected a company with a strong pipeline and financial position, with significant upcoming clinical milestones that could create substantial value. However, the continued net loss and competitive challenges in the obesity market were noted as areas of concern.
Q2-2025 Updates
Positive Updates
Pipeline Prioritization
Neumora has prioritized obesity as the lead indication for NMRA-215, an NLRP3 inhibitor with high CNS penetration, citing the potential for substantial improvements over current therapies.
Strong Financial Position
The company ended the quarter with $217.6 million in cash, cash equivalents, and marketable securities, with a cash runway projected to support operations into 2027.
Upcoming Clinical Milestones
Up to six clinical data readouts are expected over the next 18 months, including Phase I and Phase Ib studies for several assets and Phase III data for navacaprant in major depressive disorder.
Positive Preclinical Developments
Preclinical models are showing promise, particularly for NMRA-215, with potential for highly compelling data in diet-induced obesity models expected later in the year.
Negative Updates
Continued Net Loss
The total net loss for the second quarter was $52.7 million, a slight decrease from $58.7 million in the same period in 2024.
Discontinuation of a Program
The company decided not to advance a certain undisclosed program, reflecting a shift in resource allocation and prioritization.
Competitive Obesity Space
The company acknowledges the competitive nature of the obesity treatment market and the potential challenges in advancing NMRA-215 in this space.
Company Guidance
During the recent Neumora Therapeutics Second Quarter 2025 Financial Results Conference Call, the company provided extensive guidance on its future strategic initiatives and clinical developments. Neumora highlighted its prioritization of obesity as the lead indication for NMRA-215, a highly brain-penetrant NLRP3 inhibitor, with plans to initiate clinical studies in the first quarter of 2026. The company expects up to six clinical data readouts over the next 18 months, including Phase Ib data for NMRA-511 in Alzheimer's disease agitation by the end of the year, and top-line data from the Phase III KOASTAL program with navacaprant in major depressive disorder anticipated in early 2026. Additionally, Neumora disclosed a robust financial standing with $217.6 million in cash, cash equivalents, and marketable securities as of June 30, 2025, supporting operations into 2027. The company aims to leverage its expertise in neuroscience to address prevalent brain diseases and improve patient outcomes, while maintaining a strong development pipeline.

Neumora Therapeutics, Inc. Financial Statement Overview

Summary
Neumora Therapeutics, Inc. faces significant financial challenges with no revenue and substantial ongoing losses. While it maintains a strong cash position, financial instability is highlighted by negative equity and consistent cash outflows, indicating a dependency on external capital.
Income Statement
10
Very Negative
Neumora Therapeutics, Inc. has consistently reported zero revenue over the past several years, indicating a lack of monetization. All profitability metrics are negative, reflecting the company's inability to generate income. The company has significant ongoing losses, with a worsening EBIT and Net Income, suggesting high operational costs and financial strain typical for early-stage biotechnology firms.
Balance Sheet
20
Very Negative
The company maintains a strong cash position relative to its total assets, indicating good liquidity. However, continuing losses have resulted in negative equity in some years, posing a risk. The debt-to-equity ratio is not meaningful due to negative equity in prior periods, but low total debt suggests limited leverage. The equity position improved slightly, but overall financial health is weak.
Cash Flow
15
Very Negative
Neumora Therapeutics, Inc. shows consistent negative free cash flow, reflecting cash burn typical of R&D-heavy biotechnology companies. The cash flow from financing activities has been positive, indicating reliance on external funding to support operations. The operating cash flow has been negative, consistent with the lack of revenue generation.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue0.000.000.000.000.000.00
Gross Profit0.000.00-668.00K-2.70M-1.55M0.00
EBITDA-264.23M-242.98M-187.53M-135.28M-236.78M-95.41M
Net Income-252.09M-243.79M-235.93M-130.90M-237.31M-99.27M
Balance Sheet
Total Assets223.82M316.97M496.19M426.23M429.30M197.95M
Cash, Cash Equivalents and Short-Term Investments217.59M307.58M453.98M371.88M409.25M191.98M
Total Debt510.00K1.85M5.23M8.44M2.05M2.04M
Total Liabilities40.95M29.91M27.12M873.08M754.52M292.33M
Stockholders Equity182.88M287.06M469.08M-446.85M-325.22M-94.38M
Cash Flow
Free Cash Flow-194.90M-182.94M-163.40M-115.41M-76.24M-28.06M
Operating Cash Flow-195.68M-182.94M-163.28M-114.90M-75.42M-26.76M
Investing Cash Flow132.75M-70.56M64.39M-168.01M-817.00K-11.24M
Financing Cash Flow35.56M21.60M231.94M115.74M293.51M230.10M

Neumora Therapeutics, Inc. Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price1.68
Price Trends
50DMA
1.54
Positive
100DMA
1.15
Positive
200DMA
2.72
Negative
Market Momentum
MACD
0.04
Positive
RSI
52.17
Neutral
STOCH
38.24
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For NMRA, the sentiment is Neutral. The current price of 1.68 is above the 20-day moving average (MA) of 1.64, above the 50-day MA of 1.54, and below the 200-day MA of 2.72, indicating a neutral trend. The MACD of 0.04 indicates Positive momentum. The RSI at 52.17 is Neutral, neither overbought nor oversold. The STOCH value of 38.24 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for NMRA.

Neumora Therapeutics, Inc. Risk Analysis

Neumora Therapeutics, Inc. disclosed 79 risk factors in its most recent earnings report. Neumora Therapeutics, Inc. reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Neumora Therapeutics, Inc. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
64
Neutral
$192.96M-48.36%333.74%
51
Neutral
$7.95B-0.40-42.50%2.21%22.29%-1.85%
51
Neutral
$248.18M-188.58%-41.97%-20.86%
39
Underperform
$160.52M-26.94%26.33%
39
Underperform
$213.83M-77.83%43.16%
37
Underperform
$333.02M-65.91%-32.74%
33
Underperform
$272.07M-89.37%9.84%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
NMRA
Neumora Therapeutics, Inc.
1.68
-9.73
-85.28%
ALDX
Aldeyra Therapeutics
5.56
-0.35
-5.92%
CLLS
Cellectis SA
2.68
0.42
18.58%
EDIT
Editas Medicine
2.76
-0.75
-21.37%
RAPT
RAPT Therapeutics
12.93
-3.15
-19.59%
NKTX
Nkarta
2.26
-3.65
-61.76%

Neumora Therapeutics, Inc. Corporate Events

Executive/Board ChangesBusiness Operations and Strategy
Neumora Therapeutics Announces Leadership Changes and Strategy
Neutral
Feb 13, 2025

On February 13, 2025, Neumora Therapeutics announced leadership changes effective February 14, 2025, with Paul L. Berns transitioning to CEO and Chairman of the Board. Other key executives such as Joshua Pinto, Bill Aurora, and Michael Milligan have been assigned new roles. These changes are part of the company’s strategic efforts to enhance its position in the industry. Additionally, the Board approved an option repricing plan to incentivize key personnel, subject to stockholder approval, reflecting Neumora’s commitment to retaining talent while advancing its neuroscience initiatives.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 21, 2025