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Kymera Therapeutics (KYMR)
NASDAQ:KYMR
US Market
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Kymera Therapeutics (KYMR) AI Stock Analysis

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KYMR

Kymera Therapeutics

(NASDAQ:KYMR)

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Neutral 57 (OpenAI - 4o)
Rating:57Neutral
Price Target:
$45.00
▼(-27.36% Downside)
Kymera Therapeutics' overall stock score is driven by a strong earnings call that highlights strategic partnerships and a solid cash position, which partially offsets the financial challenges and valuation concerns. The technical analysis suggests positive momentum, but the company's unprofitability and lack of dividend yield weigh on the valuation score.
Positive Factors
Strategic Collaborations
These partnerships could unlock significant milestone payments and expand Kymera's reach in oncology and immuno-inflammatory treatments, enhancing its long-term growth prospects.
Financial Position
A strong cash position ensures Kymera can fund its operations and R&D activities, supporting sustained development and potential commercialization of its drug candidates.
Leadership Change
The appointment of an experienced legal executive can strengthen Kymera's governance and strategic planning, positively impacting its long-term operational efficiency and compliance.
Negative Factors
Revenue Decline
A decline in revenue growth can hinder the company's ability to fund R&D and operational activities, potentially impacting its long-term financial health and market competitiveness.
Operational Challenges
Persistent operational inefficiencies and negative profit margins can strain Kymera's resources, limiting its ability to invest in growth opportunities and achieve sustainable profitability.
Cash Flow Challenges
Negative operating cash flow suggests difficulties in generating sufficient cash from operations, which can affect Kymera's ability to finance its strategic initiatives and maintain financial stability.

Kymera Therapeutics (KYMR) vs. SPDR S&P 500 ETF (SPY)

Kymera Therapeutics Business Overview & Revenue Model

Company DescriptionKymera Therapeutics is a biotechnology company focused on developing innovative therapies that harness the power of targeted protein degradation to treat a variety of diseases, including cancer and autoimmune disorders. Leveraging its proprietary technology platform, Kymera aims to create a new class of drugs that can selectively eliminate disease-causing proteins, providing a novel approach to treatment in the pharmaceutical sector.
How the Company Makes MoneyKymera Therapeutics generates revenue primarily through partnerships and collaborations with larger pharmaceutical companies, which provide funding for the development of its drug candidates. The company may receive upfront payments, research funding, and milestone payments as its products progress through various stages of development. Additionally, Kymera could earn royalties on future sales of any approved therapies stemming from these collaborations. The company's revenue model is heavily reliant on the successful advancement of its therapeutic candidates in clinical trials and the establishment of strategic alliances to enhance its research capabilities and market reach.

Kymera Therapeutics Earnings Call Summary

Earnings Call Date:Aug 11, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Nov 04, 2025
Earnings Call Sentiment Positive
The earnings call highlighted significant advancements in Kymera's clinical programs and strategic collaborations, bolstering its financial position and setting the stage for future growth. Despite some uncertainties in dose selection and program transitions, the positive momentum and strong financial backing indicate a promising outlook.
Q2-2025 Updates
Positive Updates
Positive Results from KT-621 Trial
The KT-621 trial in healthy volunteers exceeded expectations, surpassing the target product profile with more than 95% degradation in both skin and blood at low doses.
Strong Financial Position
Kymera raised $288 million in a follow-on offering, extending its cash runway into the second half of 2028, with a current cash position of $1 billion.
Strategic Collaborations
Kymera announced partnerships with Gilead for a CDK2 degrader and Sanofi for the IRAK4 program, potentially unlocking significant milestone payments and expanding the company's reach.
Phase IIb KT-621 Trials on Track
The company has selected doses for the Phase IIb studies in AD and asthma, with the AD trial set to begin in the fourth quarter of 2025.
Advancement of IRF5 Program
The oral IRF5 program is progressing through IND-enabling studies with plans to enter Phase I testing in early 2026.
Negative Updates
Uncertainty in STAT6 Dose Selection
Questions remain about the dose selection for KT-621, with ongoing adjustments to ensure optimal translation from healthy volunteers to patients.
Challenges with KT-474 Transition
Sanofi's decision to not advance KT-474 due to better profiles observed in KT-485 indicates challenges in the development of the initial IRAK4 degrader.
Company Guidance
During Kymera Therapeutics' second quarter 2025 results call, the company provided guidance on several key metrics and future plans. They reported a cash balance of approximately $1 billion as of the end of July, extending their cash runway into the second half of 2028. This financial position is bolstered by a $288 million follow-on offering and an upfront payment from a collaboration with Gilead. The company achieved $11.5 million in revenue for the quarter, attributed to their collaboration with Sanofi. Research and development expenses were $78.4 million, with $8 million as non-cash stock-based compensation, while general and administrative expenses stood at $17.6 million, including $7.4 million in non-cash stock-based compensation. Kymera announced significant progress in their STAT6 and IRF5 programs, with plans to initiate Phase IIb studies for KT-621 in atopic dermatitis and asthma later this year and early next, respectively. They also highlighted two strategic partnerships: one with Gilead for a molecular glue degrader targeting CDK2 and another with Sanofi focusing on the IRAK4 program, emphasizing the potential to realize significant milestones from these collaborations.

Kymera Therapeutics Financial Statement Overview

Summary
Kymera Therapeutics faces significant financial challenges, with declining revenues and persistent losses impacting profitability. Despite a strong gross profit margin, the company struggles with negative net income and operational inefficiencies. The balance sheet shows low leverage, but negative returns on equity highlight profitability issues. Cash flow improvements are modest, with ongoing challenges in generating positive operating cash flow.
Income Statement
45
Neutral
Kymera Therapeutics has experienced declining revenue growth, with a significant drop of 24.07% in the TTM period. The company maintains a high gross profit margin of 95.34%, indicating efficient cost management. However, the net profit margin is deeply negative at -6.16%, reflecting substantial losses. The EBIT and EBITDA margins are also negative, indicating operational challenges.
Balance Sheet
55
Neutral
The company has a low debt-to-equity ratio of 0.09, suggesting conservative leverage. However, the return on equity is negative at -31.60%, indicating that the company is not generating positive returns for shareholders. The equity ratio is relatively stable, showing a solid equity base compared to total assets.
Cash Flow
50
Neutral
Kymera Therapeutics shows a slight improvement in free cash flow growth at 5.40% in the TTM period. The operating cash flow to net income ratio is negative, indicating cash flow challenges. However, the free cash flow to net income ratio is slightly positive, suggesting some ability to cover net losses with free cash flow.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue44.71M47.07M78.59M46.83M72.83M34.03M
Gross Profit42.63M47.07M78.59M43.85M70.44M-28.07M
EBITDA-277.16M-216.24M-143.20M-151.66M-97.64M-43.72M
Net Income-275.43M-223.86M-146.96M-151.83M-98.00M-43.95M
Balance Sheet
Total Assets1.13B978.03M575.76M603.13M605.90M487.18M
Cash, Cash Equivalents and Short-Term Investments665.45M488.74M374.88M559.49M567.61M458.73M
Total Debt85.71M87.76M84.67M17.34M17.96M17.99M
Total Liabilities159.59M142.42M180.79M112.98M146.27M203.29M
Stockholders Equity971.48M835.62M394.97M490.15M459.64M283.89M
Cash Flow
Free Cash Flow-252.92M-207.34M-137.31M-155.92M-130.54M79.03M
Operating Cash Flow-251.01M-194.50M-102.83M-153.09M-128.95M88.13M
Investing Cash Flow19.52M-404.08M139.89M20.52M-99.83M-422.59M
Financing Cash Flow499.67M608.85M4.19M153.00M250.28M289.26M

Kymera Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price61.95
Price Trends
50DMA
51.36
Positive
100DMA
48.00
Positive
200DMA
40.68
Positive
Market Momentum
MACD
2.30
Positive
RSI
62.96
Neutral
STOCH
59.70
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For KYMR, the sentiment is Positive. The current price of 61.95 is above the 20-day moving average (MA) of 58.43, above the 50-day MA of 51.36, and above the 200-day MA of 40.68, indicating a bullish trend. The MACD of 2.30 indicates Positive momentum. The RSI at 62.96 is Neutral, neither overbought nor oversold. The STOCH value of 59.70 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for KYMR.

Kymera Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
$4.31B-31.14%-11.39%
$4.19B-33.26%-49.51%-44.09%
$4.66B105.608.61%-34.45%-69.75%
$3.56B-108.49%20.02%33.45%
$3.96B-10.23-36.94%-9.10%
$7.86B-0.30-43.30%2.27%22.53%-2.21%
$630.75M-40.29%-208.46%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
KYMR
Kymera Therapeutics
61.95
14.28
29.96%
PTGX
Protagonist Therapeutics
78.51
30.89
64.87%
APLS
Apellis Pharmaceuticals
30.05
2.34
8.44%
CRNX
Crinetics Pharmaceuticals
42.06
-13.70
-24.57%
AKRO
Akero Therapeutics
54.00
23.30
75.90%
MLTX
MoonLake Immunotherapeutics
9.82
-37.18
-79.11%

Kymera Therapeutics Corporate Events

Business Operations and StrategyExecutive/Board Changes
Kymera Therapeutics Announces New Chief Legal Officer
Neutral
Sep 3, 2025

On September 3, 2025, Kymera Therapeutics announced the retirement of Ellen Chiniara as Chief Legal Officer, with Brian R. Adams succeeding her. This leadership change is part of Kymera’s strategic efforts to advance its novel programs in the field of immunology, aiming to redefine treatment possibilities with groundbreaking oral medicines.

The most recent analyst rating on (KYMR) stock is a Hold with a $43.00 price target. To see the full list of analyst forecasts on Kymera Therapeutics stock, see the KYMR Stock Forecast page.

Kymera Therapeutics’ Earnings Call: Optimism and Strategic Progress
Aug 13, 2025

Kymera Therapeutics’ recent earnings call painted a picture of optimism and strategic advancement. The company showcased significant progress in its clinical trials, highlighted by a robust pipeline and promising collaborations. Despite a strategic shift in the IRAK4 program, the overall sentiment remained positive, underscoring a strong financial position and a clear path forward.

Kymera Therapeutics Reports Q2 2025 Progress and Partnerships
Aug 12, 2025

Kymera Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing oral small molecule degrader medicines for immunological diseases, leveraging targeted protein degradation technology to address previously inaccessible disease targets and pathways.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 23, 2025