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Healios KK (JP:4593)
:4593
Japanese Market
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Healios KK (4593) AI Stock Analysis

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JP:4593

Healios KK

(4593)

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Neutral 41 (OpenAI - 4o)
Rating:41Neutral
Price Target:
¥465.00
▲(0.22% Upside)
Healios KK's stock score is primarily impacted by its poor financial performance, characterized by declining revenues and substantial losses. Technical analysis indicates a bearish trend, and valuation metrics are unattractive due to a negative P/E ratio and lack of dividend yield. These factors collectively result in a low overall stock score.

Healios KK (4593) vs. iShares MSCI Japan ETF (EWJ)

Healios KK Business Overview & Revenue Model

Company DescriptionHealios KK (4593) is a biotechnology company based in Japan that focuses on the research, development, and commercialization of innovative therapies and solutions for various medical conditions. The company primarily operates in the healthcare sector, with a strong emphasis on regenerative medicine and cell therapy. Healios aims to address unmet medical needs through its core products, which include advanced treatments for neurological disorders, cancer, and other serious illnesses, leveraging cutting-edge technologies and scientific research.
How the Company Makes MoneyHealios KK generates revenue through several key streams, primarily by developing and commercializing its proprietary therapies and treatments. The company partners with pharmaceutical firms and research institutions to further its product development and clinical trials, which can lead to milestone payments and royalties upon successful commercialization of its therapies. Additionally, Healios may receive funding through public and private grants aimed at supporting innovative health solutions. The company's strategic collaborations and partnerships are significant contributors to its financial performance, as they not only provide necessary funding but also enhance the company's credibility and market reach.

Healios KK Financial Statement Overview

Summary
Healios KK is facing significant financial difficulties. The company is struggling with declining revenues, substantial losses, and high leverage. While there are slight improvements in free cash flow growth, the overall financial health is concerning, with risks related to profitability and financial stability.
Income Statement
20
Very Negative
Healios KK's income statement reveals significant challenges. The company has experienced a dramatic decline in revenue, with a negative growth rate of 80.95% in the TTM period. Profitability metrics are concerning, with negative net profit margins and EBIT margins indicating substantial losses. The gross profit margin has also deteriorated, reflecting operational inefficiencies.
Balance Sheet
30
Negative
The balance sheet shows a high debt-to-equity ratio, suggesting significant leverage and potential financial risk. Return on equity is negative, indicating that the company is not generating returns for shareholders. The equity ratio is relatively low, which may impact financial stability.
Cash Flow
25
Negative
Cash flow analysis highlights ongoing cash flow challenges, with negative operating and free cash flows. The free cash flow to net income ratio is slightly above 1, indicating that free cash flow is not sufficient to cover net losses. The company has shown some improvement in free cash flow growth, but overall cash flow health remains weak.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue112.00M560.00M121.00M90.00M41.00M27.00M
Gross Profit-180.00M432.00M108.00M90.00M41.00M27.00M
EBITDA-2.30B-2.54B-3.16B-4.52B-3.61B-3.97B
Net Income-5.99B-4.24B-3.82B-5.17B-4.91B-5.51B
Balance Sheet
Total Assets16.84B14.19B15.15B15.03B23.97B23.17B
Cash, Cash Equivalents and Short-Term Investments6.25B3.67B6.72B7.25B15.13B13.92B
Total Debt2.60B2.66B4.53B7.15B11.96B11.40B
Total Liabilities15.56B12.11B11.29B10.65B15.33B15.32B
Stockholders Equity1.25B2.06B3.86B4.38B8.64B7.84B
Cash Flow
Free Cash Flow-2.32B-1.83B-2.85B-4.86B-5.39B-4.26B
Operating Cash Flow-2.30B-1.82B-2.82B-4.60B-5.09B-3.94B
Investing Cash Flow-1.54B-1.42B-1.12B-909.00M-736.00M-1.22B
Financing Cash Flow1.32B77.00M3.34B-2.50B6.99B803.00M

Healios KK Technical Analysis

Technical Analysis Sentiment
Negative
Last Price464.00
Price Trends
50DMA
517.24
Negative
100DMA
535.90
Negative
200DMA
424.83
Positive
Market Momentum
MACD
-12.72
Negative
RSI
39.72
Neutral
STOCH
12.79
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For JP:4593, the sentiment is Negative. The current price of 464 is below the 20-day moving average (MA) of 482.30, below the 50-day MA of 517.24, and above the 200-day MA of 424.83, indicating a neutral trend. The MACD of -12.72 indicates Negative momentum. The RSI at 39.72 is Neutral, neither overbought nor oversold. The STOCH value of 12.79 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for JP:4593.

Healios KK Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
58
Neutral
¥18.80B-5.65%-469.19%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
¥15.92B13.83%34.66%
47
Neutral
¥16.96B-8.775.58%
46
Neutral
¥15.15B-14.61-22.81%2.69%
41
Neutral
¥53.92B-78.54%10.23%
33
Underperform
¥55.07B-82.471242.62%2.56%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
JP:4593
Healios KK
463.00
263.00
131.50%
JP:4599
StemRIM Inc.
275.00
-81.00
-22.75%
JP:4894
Cuorips Inc.
6,430.00
30.00
0.47%
JP:4978
ReproCELL Inc.
170.00
65.00
61.90%
JP:7774
Japan Tissue Engineering Co., Ltd.
467.00
-38.00
-7.52%
JP:7776
CellSeed Inc.
419.00
-72.00
-14.66%

Healios KK Corporate Events

Healios Partners with Kyushu University for Brain Tumor Therapy Research
Oct 14, 2025

Healios K.K. has entered into a joint research agreement with Kyushu University’s Department of Neurosurgery to study the use of CAR-eNK cells in treating brain tumors. This collaboration aims to evaluate the antitumor effects of these genetically modified cells, potentially enhancing cancer treatment options and reinforcing Healios’ position in the regenerative medicine industry.

The most recent analyst rating on (JP:4593) stock is a Hold with a Yen476.00 price target. To see the full list of analyst forecasts on Healios KK stock, see the JP:4593 Stock Forecast page.

Healios Ends Alliance with Nikon, Plans CDMO Expansion
Oct 14, 2025

Healios K.K. has announced the termination of its business and capital alliance with Nikon Corporation, initially formed to promote regenerative medicine commercialization. The decision follows a strategic reassessment by both companies, leading them to pursue independent paths. Healios plans to expand its operations as a Contract Development and Manufacturing Organization (CDMO) in 2025, focusing on regenerative and cellular medicine, with no expected impact on its 2025 financial results.

The most recent analyst rating on (JP:4593) stock is a Hold with a Yen476.00 price target. To see the full list of analyst forecasts on Healios KK stock, see the JP:4593 Stock Forecast page.

Healios Secures Patent Approval for Universal Donor Cells in Japan
Aug 15, 2025

Healios K.K. announced the approval of a patent for its Universal Donor Cells (UDCs) by the Japan Patent Office, marking a significant milestone in the company’s innovation in regenerative medicine. The UDC technology, which reduces immune rejection risks, enhances Healios’ competitive edge globally and positions its UDCs as a potential industry standard, facilitating joint research and licensing agreements worldwide.

The most recent analyst rating on (JP:4593) stock is a Buy with a Yen320.00 price target. To see the full list of analyst forecasts on Healios KK stock, see the JP:4593 Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 30, 2025