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Ironwood Pharma (IRWD)
NASDAQ:IRWD
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Ironwood Pharma (IRWD) AI Stock Analysis

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IRWD

Ironwood Pharma

(NASDAQ:IRWD)

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Neutral 50 (OpenAI - 4o)
Rating:50Neutral
Price Target:
$1.50
▼(-9.64% Downside)
Ironwood Pharma's overall stock score is primarily impacted by its financial instability, characterized by negative equity and high leverage. While technical indicators suggest moderate positive momentum, the valuation remains unattractive due to a negative P/E ratio. The absence of earnings call insights and corporate events limits additional context.
Positive Factors
Product Portfolio
Ironwood's focus on GI diseases with a flagship product like Linzess provides a strong niche market position, leveraging specialized expertise to drive patient outcomes and revenue.
Strategic Collaborations
Collaborations expand Ironwood's market reach and product development, potentially increasing revenue through shared developments and co-promotion agreements.
Cash Generation Ability
Positive operating cash flow and efficient cash generation relative to net income indicate strong cash management, supporting operational stability.
Negative Factors
Revenue Decline
A declining revenue growth rate indicates challenges in maintaining market share or product demand, potentially impacting long-term financial health.
High Leverage
High leverage and negative equity suggest financial instability, which could constrain future growth and investment opportunities.
Profitability Challenges
Negative profitability and declining margins highlight operational inefficiencies, requiring strategic adjustments to enhance financial performance.

Ironwood Pharma (IRWD) vs. SPDR S&P 500 ETF (SPY)

Ironwood Pharma Business Overview & Revenue Model

Company DescriptionIronwood Pharmaceuticals, Inc., a healthcare company, focuses on the development and commercialization of gastrointestinal (GI) products. It markets linaclotide, a guanylate cyclase type-C agonist for the treatment of adults suffering from irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC) under the LINZESS name in the United States and Mexico, as well as under the CONSTELLA name in the Canada and European Union. The company is also developing IW-3300, a GC-C agonist for the treatment of visceral pain conditions, including interstitial cystitis/bladder pain syndrome and endometriosis; and CNP-104, an immune nanoparticle for the treatment of biliary cholangitis. The company has strategic partnerships with AbbVie Inc., AstraZeneca AB, and Astellas Pharma Inc. for the development and commercialization of linaclotide. The company was formerly known as Microbia, Inc. and changed its name to Ironwood Pharmaceuticals, Inc. in April 2008. Ironwood Pharmaceuticals, Inc. was incorporated in 1998 and is headquartered in Boston, Massachusetts.
How the Company Makes MoneyIronwood generates revenue primarily through the sales of its commercialized products, with Linzess being the most significant contributor to its earnings. The company operates on a revenue model that includes direct product sales, as well as potential royalties and milestone payments from partnerships and collaborations with other pharmaceutical companies. Ironwood has established strategic collaborations to enhance its product pipeline and expand market reach, which can further augment its revenue through shared developments and co-promotion agreements. Additionally, the company may benefit from reimbursement agreements with healthcare providers and payers, which facilitate patient access to its therapies and support revenue growth.

Ironwood Pharma Earnings Call Summary

Earnings Call Date:Aug 07, 2025
(Q4-2024)
|
% Change Since: |
Next Earnings Date:Nov 06, 2025
Earnings Call Sentiment Neutral
The earnings call highlighted strong demand growth for LINZESS and promising data for apraglutide, suggesting potential future growth. However, concerns about pricing headwinds from Medicare Part D redesign and cash liquidity tempered the overall outlook.
Q4-2024 Updates
Positive Updates
Apraglutide's Potential for Market Expansion
The data from the STARS Extend study showed that 27 patients achieved enteral autonomy, reinforcing apraglutide's potential as a blockbuster therapy for short bowel syndrome. The NDA submission is expected to be completed by the third quarter of 2025.
LINZESS Demand Growth
LINZESS saw a 12% increase in prescription demand growth in Q4 2024 compared to Q4 2023. For the full year 2024, there was an 11% prescription demand growth year-over-year, and new-to-brand volume growth was 14%.
Financial Performance and Guidance
Ironwood achieved its 2024 financial guidance with $916 million in net sales. The company expects continued strong demand growth for LINZESS in 2025, despite anticipated pricing headwinds.
Debt Reduction Efforts
Ironwood reduced its total debt balance by approximately $115 million in 2024, ending the year with $385 million drawn on its credit facility.
Negative Updates
Pricing Headwinds Due to Medicare Part D Redesign
The redesign of Medicare Part D, which went into effect earlier this year, poses a pricing headwind for LINZESS, potentially impacting revenue despite strong demand.
Cash and Liquidity Concerns
Ironwood ended 2024 with $88.6 million in cash and cash equivalents, which may be seen as limited given the company's debt obligations and the need to fund apraglutide's launch.
Company Guidance
During the Ironwood Pharmaceuticals Fourth Quarter 2024 Investor Update Conference Call, the company provided guidance for the upcoming year. They expect U.S. LINZESS net sales to range between $800 million and $850 million, forecasting high single-digit prescription demand growth despite potential pricing headwinds due to Medicare Part D redesign. Ironwood anticipates total revenue between $260 million and $290 million and adjusted EBITDA, excluding stock-based compensation, to exceed $85 million. The company aims to complete the NDA submission for apraglutide by the third quarter of 2025, with prelaunch activities underway for its potential commercialization. Ironwood reported $916 million in LINZESS net sales for 2024 and projects its cash flows will support the development and launch of apraglutide, with a focus on delivering sustained profits and reducing debt. The company ended 2024 with $88.6 million in cash and cash equivalents and $385 million in debt, having repaid $115 million over the year.

Ironwood Pharma Financial Statement Overview

Summary
Ironwood Pharma faces financial challenges with declining revenues, negative profitability, and high leverage. Despite a strong gross profit margin and positive operating cash flow, the negative equity and substantial debt levels are concerning.
Income Statement
45
Neutral
Ironwood Pharma's income statement shows a mixed performance. The TTM data reveals a negative net profit margin, indicating losses, and a declining revenue growth rate of -2.88%. The gross profit margin remains strong at 90%, but the EBIT and EBITDA margins have decreased compared to previous years. The company needs to address its declining revenues and profitability to improve its financial health.
Balance Sheet
30
Negative
The balance sheet presents significant challenges, with a negative stockholders' equity and a high debt-to-equity ratio of -1.94 in the TTM period. This indicates financial instability and potential solvency issues. The return on equity is slightly positive in the TTM, but the negative equity and high leverage pose substantial risks to the company's financial stability.
Cash Flow
50
Neutral
The cash flow statement shows a significant decline in free cash flow growth at -61.82% in the TTM period. However, the operating cash flow remains positive, and the free cash flow to net income ratio is nearly 1, suggesting efficient cash generation relative to net income. Despite the decline in free cash flow growth, the company maintains a reasonable cash flow position.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue308.52M351.41M442.74M410.60M413.75M389.52M
Gross Profit277.75M343.86M442.74M409.18M412.23M298.32M
EBITDA80.02M100.24M-924.87M261.44M233.33M141.90M
Net Income-7.88M880.00K-1.00B175.06M528.45M106.18M
Balance Sheet
Total Assets342.95M350.91M471.07M1.10B1.13B559.24M
Cash, Cash Equivalents and Short-Term Investments92.85M88.56M92.15M656.20M620.13M362.56M
Total Debt598.67M599.48M715.54M415.92M475.80M453.70M
Total Liabilities651.11M652.24M817.37M448.14M521.02M496.60M
Stockholders Equity-308.16M-301.33M-346.30M652.38M605.91M62.64M
Cash Flow
Free Cash Flow29.94M103.41M183.15M273.63M261.63M166.99M
Operating Cash Flow29.98M103.55M183.43M273.76M261.89M168.84M
Investing Cash Flow-65.00K-142.00K-1.03B-136.00K-265.00K-1.84M
Financing Cash Flow-41.95M-106.97M277.16M-237.55M-4.55M18.55M

Ironwood Pharma Technical Analysis

Technical Analysis Sentiment
Positive
Last Price1.66
Price Trends
50DMA
1.37
Positive
100DMA
1.07
Positive
200DMA
1.34
Positive
Market Momentum
MACD
0.07
Positive
RSI
59.24
Neutral
STOCH
62.29
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For IRWD, the sentiment is Positive. The current price of 1.66 is above the 20-day moving average (MA) of 1.54, above the 50-day MA of 1.37, and above the 200-day MA of 1.34, indicating a bullish trend. The MACD of 0.07 indicates Positive momentum. The RSI at 59.24 is Neutral, neither overbought nor oversold. The STOCH value of 62.29 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for IRWD.

Ironwood Pharma Risk Analysis

Ironwood Pharma disclosed 45 risk factors in its most recent earnings report. Ironwood Pharma reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 3 New Risks
1.
We may be unable to successfully integrate the business and personnel of VectivBio, and may not realize the expected benefits and anticipated synergies of such acquisition. Q4, 2023
2.
We cannot give any assurance that apraglutide will be successful in clinical trials, and if successful, will receive regulatory approval, which is necessary before it can be commercialized. Q4, 2023
3.
We may be unable to maintain the benefits associated with orphan drug designation, including market exclusivity, which may harm our business. Q4, 2023

Ironwood Pharma Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
$1.11B34.0816.16%22.61%-63.00%
$2.04B-2.82%38.68%-160.14%
$1.22B-9.28%26.66%-419.55%
$7.86B-0.30-43.30%2.27%22.53%-2.21%
$976.84M-15.57%2.25%-301.59%
$269.64M-22.98%-173.28%
$1.44B-16.34%-1.03%8.13%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
IRWD
Ironwood Pharma
1.66
-2.49
-60.00%
DVAX
Dynavax
10.38
-1.01
-8.87%
PCRX
Pacira Pharmaceuticals
21.74
4.61
26.91%
ANIP
ANI Pharmaceuticals
94.24
36.28
62.59%
EVO
Evotec AG
4.10
0.24
6.22%
COLL
Collegium Pharmaceutical
35.30
0.17
0.48%

Ironwood Pharma Corporate Events

Executive/Board Changes
Ironwood Pharma Board Member Resigns for New Role
Neutral
Oct 10, 2025

On October 7, 2025, Andrew Dreyfus announced his resignation from the Board of Directors of Ironwood Pharmaceuticals, Inc., effective November 1, 2025. His departure is due to his new role as President and CEO of the National Institute for Health Care Management Foundation and is not related to any disagreements with Ironwood Pharmaceuticals. The company expressed gratitude for his contributions during his tenure.

The most recent analyst rating on (IRWD) stock is a Hold with a $1.50 price target. To see the full list of analyst forecasts on Ironwood Pharma stock, see the IRWD Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
Ironwood Pharma Regains Nasdaq Compliance
Positive
Sep 3, 2025

On August 29, 2025, Ironwood Pharmaceuticals announced it has regained compliance with Nasdaq’s minimum bid price requirement, following a previous notice of non-compliance on May 28, 2025. This compliance ensures the company’s continued inclusion on the Nasdaq Global Select Market, marking a positive development for its market positioning.

The most recent analyst rating on (IRWD) stock is a Hold with a $1.00 price target. To see the full list of analyst forecasts on Ironwood Pharma stock, see the IRWD Stock Forecast page.

Ironwood Pharmaceuticals Reports Strong Q2 2025 Results
Aug 8, 2025

Ironwood Pharmaceuticals is a biotechnology company focused on developing and commercializing therapies for gastrointestinal and rare diseases, with a notable product, LINZESS, for treating irritable bowel syndrome with constipation and chronic idiopathic constipation.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Oct 22, 2025