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SeaStar Medical Holding (ICU)
NASDAQ:ICU
US Market
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SeaStar Medical Holding (ICU) AI Stock Analysis

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ICU

SeaStar Medical Holding

(NASDAQ:ICU)

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Underperform 33 (OpenAI - 4o)
Rating:33Underperform
Price Target:
SeaStar Medical Holding faces significant financial challenges, with negative equity and reliance on external financing posing risks to its financial health. Technical indicators show bearish momentum, and valuation metrics highlight ongoing losses, contributing to a low overall stock score.
Positive Factors
Innovative Product
The patented Selective Cytopheretic Device (SCD) offers a unique approach to treating acute kidney injury, providing a competitive edge in the biotechnology sector.
Revenue Introduction
The introduction of revenue in 2024 marks a critical milestone, indicating initial market acceptance and potential for future growth.
R&D Collaborations
Ongoing R&D collaborations could lead to new product developments and partnerships, enhancing long-term growth prospects.
Negative Factors
Negative Equity
Negative equity indicates potential solvency issues, posing risks to financial stability and limiting the company's ability to invest in growth.
Reliance on External Financing
Dependence on external financing can strain financial resources and increase vulnerability to market fluctuations, impacting long-term sustainability.
Low Profit Margins
Low and negative profit margins reflect operational inefficiencies, which may hinder the company's ability to achieve sustainable profitability.

SeaStar Medical Holding (ICU) vs. SPDR S&P 500 ETF (SPY)

SeaStar Medical Holding Business Overview & Revenue Model

Company DescriptionSeaStar Medical Holding Corporation, a medical device company, focuses on providing novel solutions and services to treat hyperinflammation and cytokine storm in critically ill patients. The company is developing and commercializing extracorporeal therapies that target the effector cells that drive systemic inflammation, causing direct tissue damage and secreting a range of pro-inflammatory cytokines that initiate and propagate imbalanced immune responses. It is developing products in various therapeutic areas, including pediatric and adult acute kidney injury on CRRT; cardiorenal syndrome in congestive heart failure with and without LVAD; myocardial stunning in end stage renal disease; and hepatorenal syndrome. The company is based in Denver, Colorado.
How the Company Makes MoneySeaStar Medical Holding makes money through the sale and licensing of its Selective Cytopheretic Device (SCD) to hospitals, healthcare providers, and potentially through partnerships with other medical technology companies. Revenue is primarily generated from the commercialization of its patented therapies targeting acute kidney injury and other inflammatory conditions. The company may also derive income from ongoing research and development collaborations and potential future expansions into additional therapeutic areas.

SeaStar Medical Holding Earnings Call Summary

Earnings Call Date:Nov 13, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 26, 2026
Earnings Call Sentiment Positive
The earnings call showcased several positive developments, including impressive survival results from Quellimmune therapy, significant revenue growth, and a high gross profit margin. The expansion of clinical sites and a strengthened financial position further underline the company's potential. However, the variability in sales and the increased enrollment requirement for the pivotal trial pose challenges. Despite these, the overall sentiment is positive with a strategic focus on overcoming hurdles and continuing growth.
Q3-2025 Updates
Positive Updates
Impressive Survival Results for Quellimmune
Reported very impressive survival results for the use of Quellimmune therapy in 21 pediatric patients, with 76% surviving through 60 days and 71% through 90 days.
Revenue Growth and Projections
Net revenue for Quellimmune in the third quarter was $183,000, a 45% increase compared to the first six months of the year. Full-year revenue for 2025 is projected to exceed $1 million.
High Gross Profit Margin
Achieved a gross profit margin of 92%, similar to a branded pharmaceutical product.
Expansion of Clinical Sites
Onboarded three additional clinical sites for the neutralized AKI trial, bringing the total to 17 active sites, with plans to activate eight more.
Financial Strengthening
Raised over $12 million to strengthen the balance sheet and extend the financial runway.
Negative Updates
Variable Quellimmune Sales
Sales continue to be variable quarter to quarter, with the requirement for a registry hampering the ability to add sites quickly.
Increased Enrollment Requirement
The neutralized AKI pivotal trial's enrollment target increased to 339 patients from 200 due to the interim analysis showing an effect size that was not significant enough.
Net Loss
Reported a net loss of approximately $3.5 million for the third quarter of 2025.
Company Guidance
During the SeaStar Medical Third Quarter Financial Results Conference Call for 2025, the company reported several key metrics indicating progress and future expectations. Net revenue for the third quarter was $183,000, reflecting a significant increase compared to $68,000 in the same period in 2024. The company anticipates full-year revenue for 2025 to exceed $1 million. SeaStar Medical achieved a gross profit margin of 92% for the quarter, comparable to branded pharmaceutical products. Enrollment in the neutralized AKI trial reached 146 out of a revised target of 339 patients, with plans to activate additional clinical sites to meet this goal by December 2026. Additionally, SeaStar Medical raised over $12 million to bolster its financial position. The company continues to focus on expanding its Quellimmune therapy to more pediatric hospital systems and is optimistic about capturing a significant portion of the estimated $100 million U.S. market.

SeaStar Medical Holding Financial Statement Overview

Summary
SeaStar Medical Holding is in a precarious financial position with negative equity and ongoing operational struggles. Despite some revenue growth, the company faces significant profitability challenges and relies heavily on external financing, highlighting potential liquidity risks.
Income Statement
30
Negative
The income statement reveals significant challenges. The company reported its first revenue in 2024, but the gross profit margin is low, and the net profit margin is negative due to substantial losses. EBIT and EBITDA margins are also negative, indicating ongoing operational struggles. Although there is a revenue introduction, past years show no revenue, and the trajectory needs monitoring.
Balance Sheet
20
Very Negative
The balance sheet shows financial instability with negative stockholders' equity, indicating potential solvency issues. The debt-to-equity ratio cannot be calculated due to negative equity, which is a significant concern. Total liabilities exceed total assets, and the equity ratio is negative, suggesting poor financial health and high financial risk.
Cash Flow
25
Negative
Cash flow analysis indicates strained liquidity with no free cash flow and operating cash flow issues. The operating cash flow to net income ratio is negligible, reflecting difficulty in converting revenue to cash. Financing cash flow is positive, indicating reliance on external financing to sustain operations, which is risky if not managed well.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue881.00K135.00K0.000.000.000.00
Gross Profit840.00K135.00K0.000.000.000.00
EBITDA-13.89M-24.58M-11.14M-11.56M-4.38M0.00
Net Income-13.66M-24.83M-26.23M-12.19M-4.60M-3.28M
Balance Sheet
Total Assets15.53M4.66M3.51M3.04M603.00K2.91M
Cash, Cash Equivalents and Short-Term Investments13.76M1.82M176.00K47.00K510.00K2.81M
Total Debt0.00574.00K9.08M8.83M2.62M83.00K
Total Liabilities4.07M6.84M17.38M23.80M3.42M74.49M
Stockholders Equity11.46M-2.18M-13.87M-20.76M-2.82M-71.58M
Cash Flow
Free Cash Flow-14.20M-16.01M-10.29M-7.79M-5.11M-5.57M
Operating Cash Flow-14.20M-16.01M-10.29M-7.79M-5.11M-5.57M
Investing Cash Flow0.000.000.000.000.000.00
Financing Cash Flow25.88M17.65M10.41M7.33M2.82M4.89M

SeaStar Medical Holding Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.34
Price Trends
50DMA
0.53
Negative
100DMA
0.67
Negative
200DMA
0.99
Negative
Market Momentum
MACD
-0.07
Negative
RSI
37.71
Neutral
STOCH
70.67
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ICU, the sentiment is Negative. The current price of 0.34 is below the 20-day moving average (MA) of 0.38, below the 50-day MA of 0.53, and below the 200-day MA of 0.99, indicating a bearish trend. The MACD of -0.07 indicates Negative momentum. The RSI at 37.71 is Neutral, neither overbought nor oversold. The STOCH value of 70.67 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for ICU.

SeaStar Medical Holding Risk Analysis

SeaStar Medical Holding disclosed 57 risk factors in its most recent earnings report. SeaStar Medical Holding reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

SeaStar Medical Holding Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
$20.74M-0.64-284.50%93.84%
43
Neutral
$21.63M-1.11-71.45%15.32%
38
Underperform
$19.37M-0.68-56.78%25.16%
38
Underperform
$19.75M>-0.01-256.30%99.02%
33
Underperform
$17.72M-0.21-290.37%1195.59%87.66%
28
Underperform
$18.97M-122.61%99.82%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ICU
SeaStar Medical Holding
0.34
-2.05
-85.77%
LSTA
Lisata Therapeutics
1.92
-0.78
-28.89%
CLSD
Clearside Biomedical
0.95
-14.65
-93.91%
APVO
Aptevo Therapeutics
1.38
-198.22
-99.31%
CING
Cingulate Inc
3.95
-0.21
-5.05%
ALLR
Allarity Therapeutics
1.09
0.01
0.93%

SeaStar Medical Holding Corporate Events

Private Placements and FinancingBusiness Operations and Strategy
SeaStar Medical Secures $6M Through Equity Agreements
Neutral
Feb 3, 2025

On January 31, 2025, SeaStar Medical Holdings entered a Securities Purchase Agreement with an institutional investor, issuing shares and warrants in both a registered direct offering and a concurrent private placement, expecting gross proceeds of approximately $6 million. The funds are intended for general corporate purposes, potentially impacting its operational capabilities and market strategy by enhancing working capital and capital expenditures.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 21, 2025