Lisata Therapeutics (LSTA) AI Stock Analysis

• Market Cap: $18.35M
• Dividend Yield: N/A
• Average Volume (3M): 34.52K
• Price to Earnings (P/E): ―
• Beta (1Y): 0.82
• Revenue Growth: N/A
• EPS Growth: 15.32%
• Country: US
• Employees: 26
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -0.49
• Shares Outstanding: 8,820,733
• 10 Day Avg. Volume: 57,561
• 30 Day Avg. Volume: 34,515
• PEG Ratio: 0.18
• Price to Book (P/B): 0.84
• Price to Sales (P/S): 24.82
• P/FCF Ratio: -1.28
• Enterprise Value/Market Cap: 0.15
• Enterprise Value/Revenue: 2.59
• Enterprise Value/Gross Profit: 2.59
• Enterprise Value/Ebitda: -0.14
• 1Y Price Target: N/A
• Price Target Upside: N/A
• Rating Consensus: N/A
• Number of Analyst Covering: 0
• EPS Forecast (FY): N/A
• Revenue Forecast (FY): N/A

• Rating: 48 Neutral
• Price Target: $2.00 ▲(2.56% Upside)

The score is held down primarily by weak financial performance (tiny revenue base, large losses, and ongoing cash burn) and bearish technicals (below key moving averages with negative MACD). Offsetting factors include a debt-free balance sheet and a more constructive earnings update featuring expense reductions, a cash runway into early 2027, and positive clinical/partnership milestones, though Phase III funding needs remain a key risk.

Positive Factors

Regulatory Achievements

These regulatory achievements enhance Lisata's competitive position by potentially accelerating development timelines and market access for certepetide.

Cash Reserves and Funding

A strong cash position provides financial stability, allowing Lisata to continue its R&D activities and clinical trials without immediate funding concerns.

Advancement of Certepetide Development

Progress in clinical trials for certepetide indicates potential for future revenue streams and strengthens Lisata's pipeline in oncology.

Negative Factors

Ongoing Financial Losses

Continued financial losses highlight operational inefficiencies and the challenge of achieving profitability, impacting long-term sustainability.

Low Revenue Generation

Minimal revenue generation underscores the dependency on successful drug development and commercialization, posing a risk to financial health.

Uncertainty in Data Release

Delays or uncertainties in clinical trial data release can affect timelines and investor confidence, potentially impacting future funding and partnerships.

Lisata Therapeutics Business Overview & Revenue Model

Company Description

Lisata Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing cellular therapies to reverse disease and/or promote the regeneration of damaged tissue. Its product candidates include HONEDRA, a recipient of SAKIGAKE designation that is in Phase II clinical trial for the treatment of critical limb ischemia; XOWNA that is in Phase IIb clinical trial for the treatment of coronary microvascular dysfunction; and CLBS201, a CD34+ cell therapy for the treatment of pre-dialysis patients with chronic kidney disease. The company was formerly known as NeoStem, Inc. and changed its name to Caladrius Biosciences, Inc. in June 2015. The company was formerly known as Caladrius Biosciences, Inc. and changed its name to Lisata Therapeutics, Inc. on September 15, 2022. Lisata Therapeutics, Inc. was incorporated in 1980 and is headquartered in Basking Ridge, New Jersey.

How the Company Makes Money

Lisata Therapeutics generates revenue primarily through the development and commercialization of its drug candidates. The company may earn money via partnerships with larger pharmaceutical companies, licensing agreements, and potential sales of its approved therapies. Additionally, Lisata could receive milestone payments and royalties based on the successful development and commercialization of its products. However, as a clinical-stage company, Lisata's revenue generation is typically dependent on the progression of its drug candidates through clinical trials and eventual regulatory approvals.

Lisata Therapeutics Financial Statement Overview

Summary

Lisata Therapeutics faces significant financial challenges with ongoing losses and negative cash flows. Despite a strong equity position and no debt, the lack of revenue consistency and high operational costs are critical concerns.

Income Statement

Lisata Therapeutics has faced significant challenges with revenue and profitability. The company reported a substantial net loss of $19,985,000 in the most recent year, despite a modest revenue of $1,000,000. Gross profit margin is quite high at 100% due to minimal cost of goods sold, but this is overshadowed by negative EBIT and EBITDA margins, indicating operational inefficiencies. The revenue growth rate is not applicable, given the absence of revenue in the prior year, which highlights volatility in revenue generation.

Balance Sheet

The company's balance sheet shows moderate strength with a high equity ratio of 84.5%, and zero total debt suggesting financial prudence in leveraging. However, the return on equity is negative due to ongoing losses, which is a concern. Cash reserves have declined over the years, reflecting the company's cash burn rate amid its losses.

Cash Flow

The cash flow statement reveals a negative free cash flow of $19,356,000, indicating the company is not generating enough cash to cover its expenditures. The operating cash flow to net income ratio is positive, yet the absolute cash flow figures remain negative. The absence of capital expenditures suggests limited investment in growth initiatives.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	1.07M	1.00M	0.00	0.00	0.00	0.00
Gross Profit	1.07M	1.00M	0.00	0.00	0.00	-63.00K
EBITDA	-19.53M	-22.23M	-25.52M	-57.53M	-29.00M	-19.08M
Net Income	-18.24M	-19.98M	-20.84M	-54.23M	-27.47M	-8.15M
Balance Sheet
Total Assets	21.76M	35.00M	54.69M	73.03M	97.01M	36.00M
Cash, Cash Equivalents and Short-Term Investments	19.00M	31.25M	50.53M	69.23M	94.97M	34.57M
Total Debt	0.00	137.00K	168.00K	485.00K	714.00K	624.00K
Total Liabilities	4.64M	5.68M	6.80M	6.71M	5.01M	3.76M
Stockholders Equity	17.37M	29.57M	48.15M	66.58M	92.25M	32.50M
Cash Flow
Free Cash Flow	-17.28M	-19.36M	-20.03M	-21.45M	-22.30M	-8.84M
Operating Cash Flow	-17.23M	-19.36M	-20.03M	-21.17M	-22.25M	-8.82M
Investing Cash Flow	16.48M	13.23M	10.10M	28.91M	-54.90M	-7.28M
Financing Cash Flow	298.00K	-206.00K	385.00K	-224.00K	85.28M	18.58M

Lisata Therapeutics Technical Analysis

• Technical Analysis Sentiment: Positive
• Last Price: 1.95
• 50DMA: Positive
• 100DMA: Negative
• 200DMA: Negative
• MACD: Negative
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For LSTA, the sentiment is Positive. The current price of 1.95 is below the 20-day moving average (MA) of 2.01, below the 50-day MA of 2.07, and below the 200-day MA of 2.36, indicating a neutral trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 56.55 is Neutral, neither overbought nor oversold. The STOCH value of 79.35 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for LSTA.

Lisata Therapeutics Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
APLM	52 Neutral	$24.00M	-0.73	-380.13%	―	―	54.41%
Sector *	51 Neutral	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
LSTA	48 Neutral	$18.35M	-1.00	-71.45%	―	―	15.32%
CTXR	48 Neutral	$18.37M	-0.22	-54.40%	―	―	18.73%
APVO	43 Neutral	$8.40M	>-0.01	-256.30%	―	―	99.02%
PCSA	41 Neutral	$7.11M	-0.09	-270.74%	―	―	72.88%

Lisata Therapeutics Corporate Events

Lisata Therapeutics Reports Q3 Results and Strategic Alliances

On November 6, 2025, Lisata Therapeutics reported its third-quarter financial results, highlighting positive data from clinical studies involving certepetide, a promising investigational drug for solid tumors. The company announced strategic alliances and a global license agreement, extending its cash runway into early 2027, and anticipates further data releases to bolster its market position.

The most recent analyst rating on (LSTA) stock is a Buy with a $15.00 price target. To see the full list of analyst forecasts on Lisata Therapeutics stock, see the LSTA Stock Forecast page.

Lisata Therapeutics Highlights Cancer Therapy Innovations

On October 14, 2025, Lisata Therapeutics issued a slide presentation for use at investor and industry conferences, highlighting its strategic focus on developing novel therapeutics for cancer treatment. The presentation emphasized the company’s proprietary technology, Certepetide, which is designed to enhance the efficacy of standard cancer therapies by modifying the tumor microenvironment. With a strong intellectual property portfolio and existing strategic partnerships, Lisata is poised for significant advancements in its clinical programs, potentially impacting its market position and stakeholder interests.

The most recent analyst rating on (LSTA) stock is a Buy with a $15.00 price target. To see the full list of analyst forecasts on Lisata Therapeutics stock, see the LSTA Stock Forecast page.