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Aptevo Therapeutics
(NASDAQ:APVO)
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Rating:43Neutral
Price Target:
$4.00
▼(-8.88% Downside)
Action:Reiterated
Date:07/28/26
The score is primarily constrained by weak financial performance (no recurring revenue, large ongoing losses, and significant cash burn implying financing risk). Technicals are also soft with the stock trading below multiple moving averages. Positive clinical and strategic corporate developments provide some offset, but they do not yet outweigh the near-term financial and trend headwinds.
Positive Factors
Clinical differentiation (AML)
Robust Phase 1b AML results with high remission and clinical benefit rates plus favorable safety materially de-risk mipletamig vs standard venetoclax+azacitidine. Durable clinical differentiation increases chances of partnering, expedited development paths, and potential transplant-enabling outcomes for frail patients.
Negative Factors
High cash burn
Sustained negative operating and free cash flow at this scale forces continued reliance on external capital. That raises dilution and financing risk, limits the company's ability to internally fund multiple programs, and constrains tactical flexibility over the next several quarters.
Read all positive and negative factors
Positive Factors
Negative Factors
Clinical differentiation (AML)
Robust Phase 1b AML results with high remission and clinical benefit rates plus favorable safety materially de-risk mipletamig vs standard venetoclax+azacitidine. Durable clinical differentiation increases chances of partnering, expedited development paths, and potential transplant-enabling outcomes for frail patients.
Read all positive factors
Aptevo Therapeutics (APVO) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$5.15M
Dividend YieldN/A
Average Volume (3M)11.64M
Price to Earnings (P/E)―
Beta (1Y)0.05
Revenue GrowthN/A
EPS Growth99.36%
CountryUS
Employees33
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-357.16
Shares Outstanding1,246,105
10 Day Avg. Volume7,942,705
30 Day Avg. Volume11,635,265
Financial Highlights & Ratios
PEG Ratio<0.01
Price to Book (P/B)<0.01
Price to Sales (P/S)0.00
P/FCF Ratio>-0.01
Enterprise Value/Market Cap>-0.01
Enterprise Value/RevenueN/A
Enterprise Value/Gross Profit<0.01
Enterprise Value/Ebitda<0.01
Forecast
1Y Price Target
$21.00Price Target Upside378.36% Upside
Rating ConsensusModerate Buy
Number of Analyst Covering1
EPS Forecast (FY)-24.13
Revenue Forecast (FY)N/A
Aptevo Therapeutics Business Overview & Revenue Model
Company Description
Aptevo Therapeutics Inc. is a clinical-stage biotechnology company primarily focused on pioneering immunotherapeutic agents for a variety of cancer treatments across the United States. Its foremost investigational drug, APVO436, is a bispecific an...
How the Company Makes Money
Aptevo’s revenue model is primarily partnership- and collaboration-driven, which is typical for clinical-stage biotechnology companies without a broad portfolio of marketed products. When it enters licensing or collaboration agreements, it can gen...
Aptevo Therapeutics Financial Statement Overview
Summary
Income Statement
12
Very Negative
Balance Sheet
38
Negative
Cash Flow
10
Very Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 0.00 | 0.00 | 0.00 | 0.00 | 3.11M | 12.29M |
| Gross Profit | -116.00K | -240.00K | -352.00K | 0.00 | 3.11M | 12.29M |
| EBITDA | -26.04M | -25.73M | -23.78M | -18.08M | 7.92M | -28.26M |
| Net Income | -26.26M | -25.97M | -24.13M | -17.41M | 8.03M | -28.46M |
Balance Sheet | ||||||
| Total Assets | 19.90M | 27.19M | 15.59M | 24.84M | 34.22M | 56.60M |
| Cash, Cash Equivalents and Short-Term Investments | 14.53M | 21.62M | 8.71M | 16.90M | 22.64M | 45.04M |
| Total Debt | 4.42M | 4.63M | 4.63M | 5.40M | 9.54M | 16.71M |
| Total Liabilities | 8.29M | 9.81M | 10.84M | 12.62M | 16.24M | 55.38M |
| Stockholders Equity | 11.61M | 17.38M | 4.75M | 12.22M | 17.97M | 1.22M |
Cash Flow | ||||||
| Free Cash Flow | -26.98M | -25.59M | -23.79M | -11.73M | -21.05M | -22.39M |
| Operating Cash Flow | -26.98M | -25.59M | -23.79M | -11.73M | -21.02M | -21.68M |
| Investing Cash Flow | 0.00 | 0.00 | 0.00 | 0.00 | -29.00K | -713.00K |
| Financing Cash Flow | 39.37M | 38.50M | 15.60M | 6.00M | -2.62M | 26.16M |
Aptevo Therapeutics Technical Analysis
Negative
4.39
Price Trends
4.60
Negative
4.66
Negative
10.40
Negative
Market Momentum
-0.06
Negative
45.93
Neutral
50.36
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For APVO, the sentiment is Negative. The current price of 4.39 is above the 20-day moving average (MA) of 4.35, below the 50-day MA of 4.60, and below the 200-day MA of 10.40, indicating a bearish trend. The MACD of -0.06 indicates Negative momentum. The RSI at 45.93 is Neutral, neither overbought nor oversold. The STOCH value of 50.36 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for APVO.
Aptevo Therapeutics Risk Analysis
Aptevo Therapeutics disclosed 57 risk factors in its most recent earnings report. Aptevo Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Aptevo Therapeutics Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
53 Neutral | $50.57M | -3.81 | -82.34% | ― | ― | 16.07% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
45 Neutral | $5.44M | -0.01 | 3114.17% | ― | ― | 80.65% | |
43 Neutral | $5.15M | -0.01 | -198.50% | ― | ― | 99.36% | |
43 Neutral | $19.57M | -1.68 | -109.94% | ― | ― | 94.17% | |
41 Neutral | $9.38M | -0.53 | -101.90% | ― | -83.00% | 19.02% |
* Healthcare Sector Average
APVO
Aptevo Therapeutics
4.11
-44.13
-91.48%
LSTA
Lisata Therapeutics
0.99
-1.50
-60.24%
MBRX
Moleculin Biotech
0.40
-16.23
-97.59%
EDSA
Edesa Biotech
5.11
2.97
138.79%
ALLR
Allarity Therapeutics
1.21
0.20
19.80%
Aptevo Therapeutics Corporate Events
Business Operations and Strategy
Aptevo Therapeutics Unveils New Solid Tumor Strategy
Positive
Jul 27, 2026
On July 27, 2026, Aptevo Therapeutics announced a new solid tumor strategy centered on a proprietary Nectin-4 x PD-L1 dual-targeting backbone and confirmed it has filed a patent application to protect this architecture. The backbone is designed to...
Business Operations and StrategyPrivate Placements and Financing
Aptevo Therapeutics Secures Grant for APVO451 Development
Positive
Jun 30, 2026
On June 29, 2026, Aptevo Therapeutics entered a Grant Award Agreement with the Andy Hill Cancer Research Endowment Fund, securing approximately $1.5 million in non-dilutive, reimbursement-based funding to support IND-enabling studies for APVO451, ...
Business Operations and StrategyPrivate Placements and Financing
Aptevo Forms Strategic Radiopharmaceutical Collaboration with Niowave
Positive
May 27, 2026
On May 25, 2026, Aptevo Research and Development LLC, a subsidiary of Aptevo Therapeutics, and Niowave entered into a 50/50 strategic collaboration to develop up to three radiopharmaceutical oncology programs combining Aptevo’s multispecific...
Business Operations and Strategy
Aptevo Highlights Strong Phase 1b AML Trial Results
Positive
May 6, 2026
On May 6, 2026, Aptevo reported new data from its RAINIER Phase 1b frontline acute myeloid leukemia trial showing that mipletamig, combined with venetoclax and azacitidine, achieved an 87% clinical benefit rate and 81% remission in 31 evaluable pa...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.