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Trellus Health PLC (GB:TRLS)
LSE:TRLS

Trellus Health PLC (TRLS) AI Stock Analysis

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GB:TRLS

Trellus Health PLC

(LSE:TRLS)

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Neutral 51 (OpenAI - 5.2)
Rating:51Neutral
Price Target:
0.75 p
â–²(88.50% Upside)
Action:ReiteratedDate:01/23/26
The score is held down primarily by weak financial performance—large ongoing losses, negative free cash flow, and declining equity—despite the benefit of having no debt. Technicals are the main positive, with strong momentum above major moving averages, but valuation remains constrained by loss-making results and no indicated dividend yield.

Trellus Health PLC (TRLS) vs. iShares MSCI United Kingdom ETF (EWC)

Trellus Health PLC Business Overview & Revenue Model

Company DescriptionTrellus Health plc provides digital chronic condition management solutions for employers and health plans. The company offers TrellusElevate, a proprietary HIPAA-compliant technology platform to coordinate and deliver personalized care remotely through telemedicine. Its platform provides patients with access to a care team, educational content resources, and remote monitoring capabilities for the treatment of inflammatory bowel diseases, which include the chronic incurable conditions of Crohn's Disease and ulcerative colitis. The company was founded in 2020 and is headquartered in White Plains, New York.
How the Company Makes Moneynull

Trellus Health PLC Financial Statement Overview

Summary
Despite sharp revenue growth off a small base and positive gross profit, the company continues to post very large operating and net losses with consistently negative cash flow. A key offset is the debt-free balance sheet, but declining equity and ongoing cash burn elevate funding and execution risk.
Income Statement
12
Very Negative
Revenue is growing off a very small base (2024 revenue up sharply versus 2023), and reported gross profit is positive. However, operating losses remain extremely large relative to sales, with deeply negative operating and net margins in each year provided. Net losses also widened in 2024 versus 2023, indicating the business has not yet demonstrated meaningful operating leverage.
Balance Sheet
58
Neutral
The balance sheet shows no debt across the periods provided, which materially reduces financial risk and refinancing pressure. That said, equity has declined significantly over time, and returns on equity are consistently negative, reflecting ongoing losses and potential dilution/financing needs if cash burn persists.
Cash Flow
18
Very Negative
Operating cash flow and free cash flow are consistently negative, signaling ongoing cash burn. While free cash flow improved in 2024 versus 2023, the company still consumed substantial cash, and cash generation has not yet stabilized to support the current cost structure without external funding.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue359.00K114.00K19.00K18.00K25.00K0.00
Gross Profit359.00K114.00K19.00K18.00K25.00K0.00
EBITDA-6.93M-7.16M-6.50M-8.27M-5.87M-1.52M
Net Income-6.89M-7.78M-6.34M-8.81M-5.90M-1.52M
Balance Sheet
Total Assets9.22M12.14M20.29M25.91M36.80M4.37M
Cash, Cash Equivalents and Short-Term Investments1.57M4.34M12.17M19.09M31.98M3.68M
Total Debt0.000.000.000.000.000.00
Total Liabilities513.00K371.00K786.00K822.00K1.52M122.00K
Stockholders Equity8.71M11.77M19.50M25.09M35.27M4.25M
Cash Flow
Free Cash Flow-6.16M-7.86M-7.63M-11.53M-8.49M-1.32M
Operating Cash Flow-6.16M-7.32M-5.27M-8.62M-4.77M-1.30M
Investing Cash Flow-291.00K-540.00K-2.35M-2.91M-3.72M-1.35M
Financing Cash Flow0.000.000.000.0038.52M10.02M

Trellus Health PLC Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
76
Outperform
£38.99M-13.4610.86%―――
52
Neutral
£18.39M-3.33-58.72%―-30.77%-6.97%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
£664.43K-0.12-56.95%―――
51
Neutral
£7.23M-7.18-15.57%―13.32%55.07%
45
Neutral
£19.46M-7.52-58.27%―37.39%-126.19%
44
Neutral
£11.36M-0.47425.97%―-4.48%61.09%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:TRLS
Trellus Health PLC
0.28
-1.48
-84.29%
GB:COG
Cambridge Cognition Holdings
39.50
-0.50
-1.25%
GB:IXI
IXICO plc
7.80
-1.70
-17.89%
GB:RENX
Renalytix
2.60
-6.40
-71.11%
GB:KOO
Kooth
107.50
-29.50
-21.53%
GB:ABDX
Abingdon Health PLC
7.75
0.50
6.90%

Trellus Health PLC Corporate Events

Private Placements and FinancingRegulatory Filings and Compliance
Trellus Health Issues New Shares on Loan Note Conversion
Neutral
Mar 10, 2026

Trellus Health plc has issued 16,438,845 new ordinary shares following the conversion of £50,000 in principal under the second tranche of its secured convertible loan notes. The issuance was slightly scaled back to offset previously over-allotted shares linked to a commitment fee for Alumni Capital LLC, leaving the new shares representing about 0.2% of the company’s capital and deemed not material.

Application has been made for the new shares to be admitted to trading on AIM, with admission expected around 13 March 2026. Following admission, Trellus Health will have 241,612,340 ordinary shares in issue, a figure that establishes the updated base for calculating shareholder voting rights and regulatory disclosure thresholds under FCA transparency rules.

The most recent analyst rating on (GB:TRLS) stock is a Hold with a £0.74 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Private Placements and FinancingRegulatory Filings and Compliance
Trellus Health Issues New Shares on Loan Note Conversion, Updates Voting Rights
Neutral
Mar 10, 2026

Trellus Health plc has issued 16,438,845 new ordinary shares following the conversion of £50,000 of principal from the second tranche of its secured convertible loan notes, with the issuance slightly reduced to offset an earlier over-allotment to Alumni Capital LLC. The new shares, which represent around 0.2% of the company’s issued share capital, are not considered material, but will lift total voting rights to 241,612,340 once admission to trading on AIM is expected to become effective around 13 March 2026, providing an updated reference point for shareholder disclosure thresholds under FCA rules.

The most recent analyst rating on (GB:TRLS) stock is a Hold with a £0.74 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Private Placements and FinancingRegulatory Filings and Compliance
Trellus Health Issues New Shares on Loan Note Conversion, Updates Voting Rights
Neutral
Mar 2, 2026

Trellus Health has issued 16,454,134 new ordinary shares following the conversion of £50,000 of principal under the second tranche of its secured convertible loan notes. The new shares are expected to be admitted to trading on AIM around 5 March 2026, increasing the company’s issued share capital and total voting rights to 225,173,495 ordinary shares, a figure shareholders can use to assess disclosure thresholds under FCA rules.

The conversion modestly reduces the company’s outstanding loan note debt while marginally diluting existing shareholders through the expanded equity base. The updated share count clarifies Trellus Health’s capital structure and provides a new reference point for investors monitoring changes in significant shareholdings and corporate control metrics.

The most recent analyst rating on (GB:TRLS) stock is a Hold with a £0.74 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Private Placements and FinancingRegulatory Filings and Compliance
Trellus Health Completes Loan Note Conversion and Increases Share Capital
Neutral
Feb 23, 2026

Trellus Health has converted approximately £65,000 of principal and accrued interest from its secured convertible loan notes into 16,804,593 new ordinary shares, completing the conversion of its first tranche notes. The new shares are expected to begin trading on AIM around 25 February 2026, increasing the company’s issued share capital to 208,719,361 ordinary shares and setting a new base for shareholders’ voting-rights calculations under UK disclosure rules.

The enlarged share capital following admission clarifies the company’s capital structure and may modestly reduce its debt burden by eliminating the converted notes. The updated total voting rights figure will be used by investors to assess whether they must disclose holdings or changes in their interests, improving transparency around significant shareholdings in Trellus Health.

The most recent analyst rating on (GB:TRLS) stock is a Hold with a £0.74 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Trellus Health Wins J&J Contract Extension as TrialSet Deployments Scale Up
Positive
Feb 18, 2026

Trellus Health has secured a six-month extension to its contract with Johnson & Johnson Health Care Systems to mid-2026, maintaining existing economic terms to provide its Trellus Elevate platform to IBD patients prescribed J&J therapies. The extension follows strong engagement and satisfaction metrics and broader patient access routes, underscoring growing pharmaceutical confidence in Trellus’s digital support model.

Alongside this, Trellus is rolling out its TrialSet offering with CROs ICON and PSI across multiple mid- and late-stage immunology and inflammation trials sponsored by Takeda and Sanofi, expanding its role across the clinical-to-commercial lifecycle. Despite modest 2025 revenues and ongoing funding needs, including a recently approved £5m convertible facility, the board believes contract wins and CRO deployments are improving recurring revenue visibility and strengthening its pharma-focused go-to-market strategy through 2026.

The most recent analyst rating on (GB:TRLS) stock is a Hold with a £0.74 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Private Placements and FinancingRegulatory Filings and Compliance
Trellus Health Issues New Shares on Conversion of Loan Notes
Neutral
Feb 18, 2026

Trellus Health plc has issued 5,637,205 new ordinary shares following the conversion of £21,000 of principal under its secured convertible loan notes, in line with shareholder approvals granted in January. The new shares are expected to be admitted to trading on AIM around 19 February 2026, modestly diluting existing holders but strengthening the company’s equity base.

Following admission, Trellus Health will have 191,914,768 ordinary shares in issue and no shares held in treasury, establishing this figure as the new denominator for calculating voting rights disclosures. The updated capital structure provides investors and regulators with a clear reference point for monitoring ownership changes under the FCA’s disclosure and transparency rules.

The most recent analyst rating on (GB:TRLS) stock is a Hold with a £0.74 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Private Placements and FinancingRegulatory Filings and Compliance
Trellus Health Issues New Shares on Loan Note Conversion
Neutral
Feb 11, 2026

Trellus Health has issued 5,538,461 new ordinary shares following the conversion of £27,000 of principal under its secured convertible loan notes, a move that modestly expands its equity base. The new shares are expected to be admitted to trading on AIM around 12 February 2026, taking the company’s total voting rights to 186,277,563 and providing an updated denominator for shareholders’ disclosure obligations under UK transparency rules.

The transaction reflects the ongoing utilisation of Trellus Health’s previously announced financing structure, with a small portion of debt transitioning into equity. While the amount raised is limited, the conversion reduces outstanding loan note principal and may incrementally strengthen the balance sheet, with implications for existing shareholders’ ownership percentages and for the company’s capital structure flexibility.

The most recent analyst rating on (GB:TRLS) stock is a Hold with a £0.74 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Business Operations and StrategyFinancial DisclosuresPrivate Placements and FinancingProduct-Related Announcements
Trellus Health Deepens Pharma and CRO Ties as TrialSetâ„¢ Deployment Gathers Pace
Positive
Feb 3, 2026

Trellus Health reported ongoing operational progress across its key verticals, particularly in clinical trials, where it signed 12‑month contracts with global CROs ICON and PSI to deploy its Trellus TrialSet™ solution in Takeda- and Sanofi-sponsored immunology and inflammation studies, and maintained its support of an AstraZeneca Phase 2 IBD trial. The company also advanced pharmaceutical and patient support programmes, including continued collaboration with Johnson & Johnson Health Care Systems and a renewed content licensing deal with Pfizer, while broadening enrolment channels and exploring further expansion. Trellus is enhancing its platforms, making TrialSet™ condition-agnostic and upgrading Trellus Elevate®, alongside data protection and compliance work, which strengthens its positioning as a scalable digital health partner for pharma and CROs. Financially, Trellus expects 2025 revenue of about $545,000, has reduced monthly cash burn to roughly $400,000, and has drawn on a £5 million convertible facility with Alumni Capital, extending its cash runway into late Q1 2026 as the board pursues additional funding and seeks to convert growing clinical and commercial validation into broader market adoption.

The most recent analyst rating on (GB:TRLS) stock is a Hold with a £0.96 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Private Placements and FinancingShareholder Meetings
Trellus Health Issues New Shares to Settle Loan Note Fees
Neutral
Jan 29, 2026

Trellus Health plc has issued 19,230,769 new ordinary shares in lieu of cash payment for settlement fees related to its secured convertible loan notes, following shareholder approval at a recent general meeting. The new shares are expected to be admitted to trading on AIM around 2 February 2026, taking the company’s total shares in issue to 180,739,102, which will also represent the total voting rights, and modestly diluting existing shareholders while strengthening the company’s capital position by conserving cash.

The most recent analyst rating on (GB:TRLS) stock is a Hold with a £1.00 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Business Operations and StrategyShareholder Meetings
Trellus Health Wins Overwhelming Shareholder Backing at General Meeting
Positive
Jan 20, 2026

Trellus Health plc announced that all resolutions put to shareholders at its General Meeting on 20 January 2026 were duly passed on a poll, with each motion receiving more than 99.8% of votes cast in favour. The strong shareholder support provides the company with the necessary corporate approvals to continue executing its strategy around its Trellus Elevate® digital platform and broader value-based chronic care offering, reinforcing its operational flexibility and governance backing as it pursues growth in the chronic disease management market.

The most recent analyst rating on (GB:TRLS) stock is a Sell with a £0.38 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Trellus Health Grants Share Options to Chairman to Align Incentives with Shareholders
Positive
Jan 19, 2026

Trellus Health has granted options over 807,541 ordinary shares to its chairman, Kevin Murphy, under the company’s existing share option plan at an exercise price of 0.525p, matching the pricing of a recent loan note arrangement with Mount Sinai. The options vest in 12 equal quarterly instalments over approximately 39 months and are subject to standard lock-in and leaver provisions; the independent directors say the award is fair and reasonable and is intended to align the chairman’s incentives closely with those of shareholders, signalling continued emphasis on governance and long-term value creation as the company pursues its chronic-condition management strategy.

The most recent analyst rating on (GB:TRLS) stock is a Sell with a £0.38 price target. To see the full list of analyst forecasts on Trellus Health PLC stock, see the GB:TRLS Stock Forecast page.

Business Operations and StrategyPrivate Placements and FinancingShareholder Meetings
Trellus Health Seeks Up to £5m via Convertible Loan Notes to Extend Cash Runway
Negative
Dec 30, 2025

Trellus Health plans to raise up to £5 million via a 12‑month secured convertible loan note facility from an institutional investor, with warrants attached and funds available in staged tranches, subject to shareholder approval at a general meeting on 20 January 2026. The financing is designed to extend the company’s cash runway, with the first two tranches expected to fund operations until late Q1 2026, support ongoing commercial initiatives and partnership discussions, and provide flexibility over the timing and scale of capital drawdowns, but the board warns that failure to secure shareholder backing or alternative funding would likely result in the company ceasing to be a going concern and entering administration.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 23, 2026