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Trellus Health PLC (GB:TRLS)
LSE:TRLS

Trellus Health PLC (TRLS) AI Stock Analysis

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GB:TRLS

Trellus Health PLC

(LSE:TRLS)

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Neutral 44 (OpenAI - 5.2)
Rating:44Neutral
Price Target:
0.39p
▼(-3.00% Downside)
The score is primarily weighed down by weak financial performance—large ongoing losses and persistent cash burn—despite the benefit of having no debt. Technical signals also remain clearly bearish (below key moving averages with negative momentum), while valuation provides limited support because the company is unprofitable and has no stated dividend yield.

Trellus Health PLC (TRLS) vs. iShares MSCI United Kingdom ETF (EWC)

Trellus Health PLC Business Overview & Revenue Model

Company DescriptionTrellus Health plc provides digital chronic condition management solutions for employers and health plans. The company offers TrellusElevate, a proprietary HIPAA-compliant technology platform to coordinate and deliver personalized care remotely through telemedicine. Its platform provides patients with access to a care team, educational content resources, and remote monitoring capabilities for the treatment of inflammatory bowel diseases, which include the chronic incurable conditions of Crohn's Disease and ulcerative colitis. The company was founded in 2020 and is headquartered in White Plains, New York.
How the Company Makes Money

Trellus Health PLC Financial Statement Overview

Summary
Income Statement
Balance Sheet
Cash Flow
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue359.00K114.00K19.00K18.00K25.00K0.00
Gross Profit359.00K114.00K19.00K18.00K25.00K0.00
EBITDA-6.93M-7.16M-6.50M-8.27M-5.87M-1.52M
Net Income-6.89M-7.78M-6.34M-8.81M-5.90M-1.52M
Balance Sheet
Total Assets9.22M12.14M20.29M25.91M36.80M4.37M
Cash, Cash Equivalents and Short-Term Investments1.57M4.34M12.17M19.09M31.98M3.68M
Total Debt0.000.000.000.000.000.00
Total Liabilities513.00K371.00K786.00K822.00K1.52M122.00K
Stockholders Equity8.71M11.77M19.50M25.09M35.27M4.25M
Cash Flow
Free Cash Flow-6.16M-7.86M-7.63M-11.53M-8.49M-1.32M
Operating Cash Flow-6.16M-7.32M-5.27M-8.62M-4.77M-1.30M
Investing Cash Flow-291.00K-540.00K-2.35M-2.91M-3.72M-1.35M
Financing Cash Flow0.000.000.000.0038.52M10.02M

Trellus Health PLC Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
58
Neutral
£10.89M-6.32-15.57%13.32%55.07%
58
Neutral
£11.35M-0.31-122.54%-57.03%-15.71%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
44
Neutral
£646.03K-0.12-56.95%
38
Underperform
£10.43M-0.26-407.49%72.17%79.03%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:TRLS
Trellus Health PLC
0.40
-0.20
-33.33%
GB:IXI
IXICO plc
11.75
0.25
2.17%
GB:OBD
Oxford BioDynamics
0.24
-0.66
-73.00%
GB:VRCI
Verici Dx Plc
0.75
-4.35
-85.29%

Trellus Health PLC Corporate Events

Business Operations and StrategyPrivate Placements and FinancingShareholder Meetings
Trellus Health Seeks Up to £5m via Convertible Loan Notes to Extend Cash Runway
Negative
Dec 30, 2025

Trellus Health plans to raise up to £5 million via a 12‑month secured convertible loan note facility from an institutional investor, with warrants attached and funds available in staged tranches, subject to shareholder approval at a general meeting on 20 January 2026. The financing is designed to extend the company’s cash runway, with the first two tranches expected to fund operations until late Q1 2026, support ongoing commercial initiatives and partnership discussions, and provide flexibility over the timing and scale of capital drawdowns, but the board warns that failure to secure shareholder backing or alternative funding would likely result in the company ceasing to be a going concern and entering administration.

Business Operations and StrategyPrivate Placements and Financing
Trellus Health Secures $600,000 Loan to Boost Commercial Strategy
Positive
Nov 24, 2025

Trellus Health PLC has entered into an unsecured loan agreement with its substantial shareholder, Icahn School of Medicine at Mount Sinai, for $600,000 to support its commercial strategy and extend its cash runway to January 2026. The loan, which is non-interest bearing for the first six months, will help the company focus on securing additional commercial contracts with pharmaceutical companies and CROs, with recent contracts signed with two leading global CROs to implement trials by year-end.

Business Operations and Strategy
Trellus Health Expands Clinical Trial Services with New CRO Contract
Positive
Nov 7, 2025

Trellus Health PLC has signed a 12-month contract with a leading global clinical research organization to utilize its Trellus TrialSet™ offering, focusing on immunology and inflammation. This marks the company’s second contract with a major CRO, reinforcing its strategic growth in the clinical trials sector. The contract includes upfront, monthly, and milestone payments, and is structured around key performance indicators to optimize trial recruitment and reduce screen failure rates. This development highlights Trellus Health’s growing recognition in the pharmaceutical sector, although it does not immediately extend the company’s cash runway beyond December 2025.

Business Operations and Strategy
Trellus Health Secures Strategic Contract with Leading CRO
Neutral
Nov 7, 2025

Trellus Health PLC has signed a 12-month contract with a leading global clinical research organization to utilize its Trellus TrialSet™ offering, focusing on immunology and inflammation for two late-stage clinical trials. This contract, which includes various performance-based fees, marks the company’s second agreement with a major CRO, underscoring the strategic importance of the clinical trials sector for Trellus Health. While the contract does not immediately extend the company’s financial runway, it highlights the growing recognition of Trellus Health’s value in the pharmaceutical sector.

Business Operations and Strategy
Trellus Health Secures Key CRO Contract and Preferred Vendor Status
Positive
Oct 22, 2025

Trellus Health PLC has signed a 12-month contract with a leading global Clinical Research Organisation (CRO) to enhance recruitment and enrollment for a mid-stage clinical trial in immunology and inflammation. This contract marks a strategic move in the clinical trials sector, with Trellus TrialSet™ designed to improve participant readiness and retention through resilience-based methodologies. Additionally, Trellus Health has been granted preferred vendor status by another major CRO, reinforcing its position in the clinical trials vertical and providing access to a broader client base, although not immediately impacting revenue.

Business Operations and StrategyPrivate Placements and Financing
Trellus Health Extends Cash Runway and Advances Contract Negotiations
Positive
Oct 21, 2025

Trellus Health PLC has announced updates regarding its financial and operational strategies, including extending its cash runway to early December 2025 through cost-saving measures and reducing its monthly cash burn. The company is in late-stage contract negotiations for a collaboration with a leading global CRO, which could enhance its positioning in the clinical trials sector. Additionally, Trellus Health is exploring potential equity fundraising to support future growth, though no definitive funding transactions have been concluded yet.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 04, 2026