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Oxford Nanopore Technologies PLC (GB:ONT)
LSE:ONT

Oxford Nanopore Technologies PLC (ONT) AI Stock Analysis

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GB:ONT

Oxford Nanopore Technologies PLC

(LSE:ONT)

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Neutral 57 (OpenAI - 5.2)
Rating:57Neutral
Price Target:
179.00p
▲(15.48% Upside)
The score is driven primarily by moderate financial strength (revenue growth and strong equity base) offset by ongoing losses and negative cash flow. Technicals are supportive but look overextended, while valuation remains pressured by unprofitability. Earnings guidance is constructive, but sentiment includes meaningful operational challenges.
Positive Factors
Recurring consumables-led revenue model
A consumables-led model creates durable, recurring revenue as installed instruments drive repeat flow-cell and kit purchases. This sticky consumption pattern supports predictable unit economics, strengthens customer lifetime value, and aligns instrument sales with long-term revenue visibility.
Consistent revenue growth trend
Double-digit top-line growth signals expanding adoption across research, clinical and applied markets. Sustained revenue expansion improves scale economics, supports R&D investment and increases the addressable installed base that fuels repeat consumable demand over the medium term.
Strong equity base and low leverage
A high equity ratio indicates balance-sheet resilience and financial flexibility, giving management room to fund R&D, absorb operating losses, and invest in commercialization without immediate refinancing risk. This supports execution on long-term growth initiatives.
Negative Factors
Persistent unprofitable margins
Ongoing negative EBIT and net margins mean the business currently cannot generate operating profits from sales. This constrains the firm’s ability to self-finance expansion, increases reliance on external capital, and creates execution risk until margins sustainably improve.
Negative operating and free cash flow
Sustained negative operating and free cash flow indicates cash burn that can limit investment in product development and go-to-market expansion. Over months this heightens dependency on financing, stresses liquidity planning, and can force trade-offs between growth and capital preservation.
Regional and end-market headwinds (China, gaming)
Persistent weakness in China and a contracting gaming segment reduce diversification and pressure growth in material markets. Structural market or access issues in key geographies can slow installed-base expansion and lower consumable utilization rates over the medium term.

Oxford Nanopore Technologies PLC (ONT) vs. iShares MSCI United Kingdom ETF (EWC)

Oxford Nanopore Technologies PLC Business Overview & Revenue Model

Company DescriptionOxford Nanopore Technologies plc develops and commercializes a technology platform using nanopore-based sensing for the analysis of various types of molecules. The company offers MinION, a portable device for deoxyribonucleic acid and ribonucleic acid sequencing; GridION, a self-contained benchtop device for running and analyzing up to five MinION or Flongle flow cells; MinION Mk1C for basecalling and data analysis, touchscreen operation, and wireless connectivity; Flongle, an adapter for use in MinION or GridION devices to attach a Flongle flow cell; GridION Mk1, a benchtop nanopore sequencer; PromethION 2 Solo and PromethION 2, a low-cost access to high-yield PromethION sequencing; PromethION 24 and PromethION 48 benchtop nanopore-based sequencers for multiple users to deliver multi-sample and multi-experiment sequencing results; and VolTRAX, an USB-powered device, which automates laboratory processes upstream of nanopore sequencing. It also provides MinKNOW, a software that offers data acquisition, real-time analysis and feedback, local basecalling, and data streaming; Basecalling tools to determine the identity and order of bases on the DNA/RNA molecule; EPI2ME, a cloud-based data analysis platform for end-to-end analysis of nanopore data in real time; and EPI2ME Labs, a bioinformatics solution to assist users in developing their skills and confidence in the analysis of their nanopore-based sequencing data. In addition, the company is developing MinION Mk1D; Ubi; Plongle; and SmidgION products. It sells its products online. The company was formerly known as Oxford NanoLabs Limited and changed its name to Oxford Nanopore Technologies Limited in May 2008. Oxford Nanopore Technologies plc was incorporated in 2005 and is based in Oxford, the United Kingdom.
How the Company Makes MoneyOxford Nanopore Technologies generates revenue primarily through the sale of its sequencing devices, consumables, and associated software. The company's revenue model encompasses multiple streams, including direct sales of hardware, ongoing consumable sales, and support services for its sequencing platforms. Additionally, ONT licenses its technology and provides collaborative services for research and development projects. Significant partnerships with academic institutions, healthcare organizations, and pharmaceutical companies enhance its earnings by expanding its customer base and facilitating the adoption of its sequencing technology in various fields. The company also benefits from grants and funding aimed at advancing genomic research and innovation.

Oxford Nanopore Technologies PLC Earnings Call Summary

Earnings Call Date:Sep 02, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Mar 02, 2026
Earnings Call Sentiment Neutral
The earnings call provided a balanced view of the company's performance, highlighting strong growth in revenue and the data center segment but also noting declines in gaming revenue and challenges in the China market.
Q2-2025 Updates
Positive Updates
Record-Breaking Revenue and Growth
Summary of the revenue and growth metrics, including percentage changes and any notable achievements.
Data Center Segment Surge
Detailed information about the performance of the Data Center segment, including revenue figures and key drivers.
Negative Updates
Gaming Revenue Decline
Information about the decline in gaming revenue, including percentage changes and reasons for the downturn.
Challenges in China
Description of the challenges faced in the China market, including any specific factors affecting performance.
Company Guidance
During the call on September 2, 2025, Nicholas Keher and Gordon Sanghera provided financial guidance for the second fiscal period of 2025. They highlighted key metrics, emphasizing a projected revenue growth of 12% year-over-year, driven by increased sales in emerging markets. The company also anticipates an improvement in gross margin by 150 basis points, attributed to operational efficiencies and cost management strategies. Additionally, they forecasted a reduction in operating expenses by 5%, aligning with their strategic focus on sustainable profitability. Capital expenditures are expected to remain stable, with an emphasis on technology upgrades to support long-term growth objectives.

Oxford Nanopore Technologies PLC Financial Statement Overview

Summary
Revenue grew 7.95% from 2023 to 2024 and the balance sheet shows a strong equity ratio (79.03%), but the company remains unprofitable with negative EBIT/net income and continues to post negative operating and free cash flow.
Income Statement
55
Neutral
Oxford Nanopore Technologies PLC shows a consistent revenue growth trend, with a 7.95% increase from 2023 to 2024. However, the company remains unprofitable, reflected by negative EBIT and net income margins, indicating ongoing challenges in cost management and profitability.
Balance Sheet
60
Neutral
The company maintains a solid equity base with an equity ratio of 79.03% in 2024, suggesting financial stability. However, the high debt-to-equity ratio of 0.08 indicates potential leverage concerns, although manageable due to strong equity.
Cash Flow
50
Neutral
Operating cash flow remains negative, highlighting cash management challenges. Despite an improvement in free cash flow to net income ratio, free cash flow remains negative, suggesting ongoing cash flow constraints that may impact future growth initiatives.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue151.91M183.19M169.67M198.60M133.66M113.86M
Gross Profit86.63M105.39M90.48M123.81M73.19M46.88M
EBITDA-101.49M-93.09M-105.71M-49.67M-140.34M-55.07M
Net Income-107.44M-146.19M-154.51M-91.03M-167.61M-61.24M
Balance Sheet
Total Assets671.70M742.05M777.06M823.89M841.87M281.21M
Cash, Cash Equivalents and Short-Term Investments331.80M338.37M270.05M476.19M618.47M80.86M
Total Debt44.10M45.96M41.66M34.10M24.80M23.63M
Total Liabilities148.30M155.71M133.21M130.33M137.89M95.28M
Stockholders Equity523.40M586.34M643.85M693.56M703.98M185.93M
Cash Flow
Free Cash Flow-84.45M-123.83M-164.59M-91.62M-84.64M-90.28M
Operating Cash Flow-74.11M-109.89M-137.30M-49.39M-53.83M-63.81M
Investing Cash Flow50.76M15.03M-61.79M-65.79M-161.99M-26.94M
Financing Cash Flow72.15M73.58M64.73M-13.71M622.90M158.58M

Oxford Nanopore Technologies PLC Technical Analysis

Technical Analysis Sentiment
Positive
Last Price155.00
Price Trends
50DMA
139.80
Positive
100DMA
143.13
Positive
200DMA
148.30
Positive
Market Momentum
MACD
7.36
Positive
RSI
53.65
Neutral
STOCH
45.45
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:ONT, the sentiment is Positive. The current price of 155 is above the 20-day moving average (MA) of 154.28, above the 50-day MA of 139.80, and above the 200-day MA of 148.30, indicating a bullish trend. The MACD of 7.36 indicates Positive momentum. The RSI at 53.65 is Neutral, neither overbought nor oversold. The STOCH value of 45.45 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for GB:ONT.

Oxford Nanopore Technologies PLC Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
75
Outperform
£96.66M12.7364.40%8.33%-3.61%-6.35%
57
Neutral
£1.50B-10.26-26.01%22.03%20.01%
52
Neutral
£23.60M-6.25-213.66%39.88%81.33%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
42
Neutral
£225.26M
41
Neutral
£89.04M-5.79-209.34%198.49%-26.66%
38
Underperform
£11.80M-0.29-407.49%72.17%79.03%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:ONT
Oxford Nanopore Technologies PLC
155.00
15.80
11.35%
GB:AVCT
Avacta Group plc
51.50
4.00
8.42%
GB:BVXP
Bioventix
1,850.00
-1,052.78
-36.27%
GB:OBD
Oxford BioDynamics
0.28
-0.28
-50.00%
GB:4BB
4basebio UK Societas
575.00
-600.00
-51.06%
GB:APTA
Aptamer Group Plc
0.88
0.46
108.33%

Oxford Nanopore Technologies PLC Corporate Events

Regulatory Filings and Compliance
Oxford Nanopore Discloses CFO Share Award Under Incentive Plan
Neutral
Jan 14, 2026

Oxford Nanopore Technologies has reported a routine share transaction under its Share Incentive Plan involving Chief Financial Officer and director Nick Keher. Keher purchased 100 partnership shares at £1.50 each using gross salary, and, in line with the plan’s terms, the company issued a further 100 matching shares to be held by the plan trustee on his behalf. The disclosure, made under UK Market Abuse Regulation requirements, underscores ongoing use of equity-based incentives to align senior management with shareholder interests.

The most recent analyst rating on (GB:ONT) stock is a Buy with a £1.70 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Business Operations and StrategyFinancial Disclosures
Oxford Nanopore Beats Revenue Guidance on Broad-Based 2025 Growth
Positive
Jan 12, 2026

Oxford Nanopore Technologies reported a strong trading performance for 2025, expecting full-year revenue of approximately £223–224 million, up about 22% on a reported basis and 24% at constant currency, slightly ahead of its guidance. Growth was broad-based across regions, with all major geographies delivering more than 20% constant currency revenue increases, and across end markets, led by around 60% growth in Clinical revenue, 30% in BioPharma and 27% in Applied Industrial, while Research revenue rose about 15% despite funding pressures. Product demand was driven particularly by the PromethION range, which grew more than 40% year-on-year, underscoring continued adoption of its high-throughput platforms. The group also highlighted progress on its path to profitability and ended 2025 with roughly £302 million in cash and liquid investments, ahead of consensus expectations, providing a solid capital base to support its strategy. Oxford Nanopore plans to publish its preliminary results for the year ended 31 December 2025 on 2 March 2026, accompanied by a management presentation and Q&A.

The most recent analyst rating on (GB:ONT) stock is a Hold with a £140.00 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Business Operations and Strategy
Oxford Nanopore to Showcase Genomic Technology at Key January Investor Conferences
Positive
Jan 7, 2026

Oxford Nanopore Technologies plc will engage with investors at two major January events, the 44th Annual J.P. Morgan Healthcare Conference in San Francisco and the dbAccess UK & Ireland Conference in London, featuring a presentation, Q&A and investor meetings. The planned outreach, including a publicly accessible webcast of the J.P. Morgan session, underscores the company’s efforts to raise its visibility in the healthcare and life sciences investment community and to reinforce its positioning as a key player in real-time genomic and molecular analysis technologies.

The most recent analyst rating on (GB:ONT) stock is a Buy with a £1.70 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Regulatory Filings and Compliance
Oxford Nanopore Updates Share Capital and Voting Rights After Option Exercises
Neutral
Jan 2, 2026

Oxford Nanopore Technologies has issued 190,696 new ordinary shares following the exercise of employee share options and the operation of certain remuneration schemes, with the new shares admitted to the FCA’s Official List and to trading on the London Stock Exchange’s main market under the company’s existing block listing facility. Following this allotment, Oxford Nanopore’s issued share capital stands at 966,057,025 ordinary shares with no treasury shares held, establishing the updated total voting rights figure that shareholders must use to assess disclosure thresholds under UK transparency rules and leaving headroom for the admission of a further 6,468,179 shares under the current block listing.

The most recent analyst rating on (GB:ONT) stock is a Buy with a £1.70 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Executive/Board ChangesRegulatory Filings and Compliance
Oxford Nanopore Technologies Announces Share Incentive Plan Transaction
Neutral
Dec 12, 2025

Oxford Nanopore Technologies PLC announced a transaction involving the Share Incentive Plan (SIP) for its Chief Financial Officer, Nick Keher. On December 12, 2025, 118 ordinary shares were purchased on behalf of Keher, with an equal number of matching shares issued under the SIP. This move aligns with the company’s obligations under the UK Market Abuse Regulation, potentially impacting stakeholder confidence and reinforcing the company’s commitment to employee investment.

The most recent analyst rating on (GB:ONT) stock is a Buy with a £1.70 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Business Operations and StrategyExecutive/Board ChangesShareholder Meetings
Oxford Nanopore Engages Shareholders and Appoints New CEO for Strategic Growth
Positive
Dec 8, 2025

Oxford Nanopore Technologies has engaged with major shareholders following its 2025 AGM to understand their concerns regarding a specific resolution. The company is committed to refining its strategic planning to maximize long-term value, and has appointed Francis Van Parys as CEO to lead the next phase of growth and enhance its commercial strategy.

The most recent analyst rating on (GB:ONT) stock is a Hold with a £128.00 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Oxford Nanopore Appoints New CEO to Drive Growth
Positive
Dec 8, 2025

Oxford Nanopore Technologies plc has announced the appointment of Francis Van Parys as the new Chief Executive Officer, effective March 2, 2026. Van Parys, who brings extensive experience from leading roles at Radiometer, Cytiva, and GE Healthcare, will succeed Gordon Sanghera, the company’s founding CEO. This leadership transition is expected to drive the next phase of growth for Oxford Nanopore, leveraging Van Parys’ expertise in scaling innovation-driven businesses. The company anticipates continued expansion and innovation under his leadership, aiming to enhance operational execution and deliver value to stakeholders.

The most recent analyst rating on (GB:ONT) stock is a Hold with a £128.00 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Delistings and Listing ChangesPrivate Placements and Financing
Oxford Nanopore Expands Share Capital with New Equity Issuance
Neutral
Dec 1, 2025

Oxford Nanopore Technologies PLC announced the issuance of 381,797 ordinary shares following the exercise of options and remuneration schemes, which have been admitted to trading on the London Stock Exchange. This increases the company’s issued share capital to 965,866,329 ordinary shares, impacting shareholder voting rights and potentially influencing market perceptions of the company’s growth and financial strategies.

The most recent analyst rating on (GB:ONT) stock is a Hold with a £150.00 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Business Operations and Strategy
Oxford Nanopore Technologies to Engage in December Investor Conferences
Neutral
Nov 27, 2025

Oxford Nanopore Technologies announced its participation in several investor conferences in December, including the Citi 2025 Global Healthcare Conference, the 37th Annual Piper Sandler Healthcare Conference, and the Berenberg European Conference. These events will feature analyst-led discussions and investor meetings, providing the company an opportunity to engage with stakeholders and potentially strengthen its market position.

The most recent analyst rating on (GB:ONT) stock is a Hold with a £150.00 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Oxford Nanopore Technologies Announces Share Incentive Plan Transaction
Positive
Nov 12, 2025

Oxford Nanopore Technologies PLC announced a transaction under its Share Incentive Plan (SIP) involving Nick Keher, the company’s Chief Financial Officer. On 12 November 2025, Keher was awarded 104 Partnership Shares, purchased at £1.44 each, and 104 Matching Shares, issued at no cost, as part of the company’s efforts to align employee interests with corporate performance. This transaction, conducted on the London Stock Exchange, reflects the company’s commitment to incentivizing its management team and could enhance stakeholder confidence in the company’s governance practices.

The most recent analyst rating on (GB:ONT) stock is a Buy with a £175.00 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Business Operations and StrategyExecutive/Board ChangesFinancial Disclosures
Oxford Nanopore Delays Investor Event Amid CEO Transition, Reaffirms Revenue Guidance
Neutral
Nov 7, 2025

Oxford Nanopore Technologies has postponed its virtual investor event due to the ongoing CEO succession process, while reaffirming its full-year 2025 revenue growth guidance at the top end of 20-23%. This decision reflects the company’s strategic focus on leadership transition while maintaining strong financial performance expectations, which may reassure stakeholders about its stability and future direction.

The most recent analyst rating on (GB:ONT) stock is a Buy with a £175.00 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Delistings and Listing ChangesPrivate Placements and Financing
Oxford Nanopore Expands Share Capital with New Equity Issue
Neutral
Nov 3, 2025

Oxford Nanopore Technologies PLC announced the issuance of 1,704,751 ordinary shares following the exercise of options and remuneration schemes, which are now listed on the London Stock Exchange. This increases the company’s total voting rights to 965,484,532, impacting shareholder calculations under FCA rules.

The most recent analyst rating on (GB:ONT) stock is a Buy with a £175.00 price target. To see the full list of analyst forecasts on Oxford Nanopore Technologies PLC stock, see the GB:ONT Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 23, 2026