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Aptamer Group Plc (GB:APTA)
LSE:APTA

Aptamer Group Plc (APTA) AI Stock Analysis

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GB:APTA

Aptamer Group Plc

(LSE:APTA)

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Neutral 52 (OpenAI - 5.2)
Rating:52Neutral
Price Target:
0.88p
▲(10.50% Upside)
The score is held back primarily by very weak financial performance (sharp revenue decline, ongoing losses, and negative cash flows). Technicals are the main offset, showing a clear uptrend with supportive momentum. Valuation remains constrained by unprofitability and the absence of dividend information.
Positive Factors
Improved leverage management
An improved debt-to-equity ratio indicates the company has reduced leverage pressure, enhancing financial flexibility. Over months this reduces refinancing risk, preserves optionality for R&D or partnerships, and supports a steadier runway for executing its aptamer commercialization strategy.
Diversified revenue model (services, partnerships, product sales)
Multiple revenue streams — fee-for-service discovery, milestone-driven partnerships, and direct product sales — provide structural diversification. This mix can stabilize cash flows, create recurring client relationships, and align incentives with pharma partners for sustained long-term revenue generation.
Lean headcount supports lower fixed costs
A small employee base suggests a lean cost structure and operational agility. Over several months this can stretch cash runway, enable focused R&D investment, and allow faster pivots in development priorities versus larger peers, aiding survival while commercial traction is pursued.
Negative Factors
Severe recent revenue collapse
A near-total revenue decline undermines the firm's ability to achieve scale and fund ongoing R&D. Over 2-6 months, recovering from such a structural drop typically requires new contracts or financing; failure to restore sustainable top-line puts strategic plans and partner confidence at risk.
Persistent negative operating and free cash flow
Ongoing negative operating and free cash flow erodes liquidity and forces reliance on external capital. Structurally this constrains the firm's ability to fund development milestones, scale commercial operations, or absorb setbacks without dilutive financings or curtailed programs over the medium term.
Negative margins and returns
Sustained negative gross, EBIT and net margins indicate fundamental issues in pricing, cost structure or product mix. This makes it difficult to convert revenue growth into profitability, implying structural work is needed on margins before the business can generate durable shareholder returns.

Aptamer Group Plc (APTA) vs. iShares MSCI United Kingdom ETF (EWC)

Aptamer Group Plc Business Overview & Revenue Model

Company DescriptionAptamer Group Plc (APTA) is a biotechnology company that specializes in the development of novel aptamer-based technologies for various applications in diagnostics, therapeutics, and research. The company operates primarily in the life sciences sector, focusing on providing high-quality, synthetic aptamers—short, single-stranded oligonucleotides that can bind to specific target molecules. Aptamer Group's core products and services include the design and production of aptamers for use in pharmaceutical development, as well as tools for biomarker discovery and diagnostics.
How the Company Makes MoneyAptamer Group Plc generates revenue through several key streams. Primarily, the company earns income by providing custom aptamer discovery services to pharmaceutical and biotech companies, which are looking for specific binding agents for their drug development processes. Additionally, the company may generate revenue from partnerships and collaborations with industry players that leverage its aptamer technology for research and development purposes. These partnerships often involve upfront payments and milestone payments tied to the progress of joint projects. Furthermore, Aptamer Group may also sell its proprietary aptamer products directly to customers in the diagnostics and life sciences sectors, contributing to its revenue. Overall, the company's financial success is supported by its innovative technology, strategic collaborations, and a growing demand for aptamer-based solutions in the biotechnology industry.

Aptamer Group Plc Financial Statement Overview

Summary
Weak fundamentals: severe revenue decline (-98.8%), persistent losses (negative net/EBIT margins), and negative operating/free cash flow. Balance sheet leverage has improved, but returns remain negative.
Income Statement
25
Negative
Aptamer Group Plc has experienced significant revenue declines, with a negative revenue growth rate of -98.8% in the most recent year. The company is facing substantial losses, as indicated by negative net profit margins and EBIT margins. The gross profit margin has also decreased over time, indicating challenges in maintaining profitability.
Balance Sheet
40
Negative
The company's debt-to-equity ratio has improved, indicating better leverage management. However, the return on equity remains negative, reflecting ongoing losses. The equity ratio is relatively stable, but the overall financial health is weakened by consistent negative returns.
Cash Flow
30
Negative
Aptamer Group Plc's cash flow situation is concerning, with negative operating and free cash flows. Although there is a slight improvement in free cash flow growth, the operating cash flow to net income ratio is negative, indicating cash flow challenges relative to net income.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue1.20M1.20M860.00K1.75M4.04M1.28M
Gross Profit465.00K350.00K250.00K359.00K2.69M538.40K
EBITDA-2.33M-2.28M-2.81M-7.36M-2.19M-2.24M
Net Income-2.42M-2.42M-2.96M-7.84M-2.09M-1.85M
Balance Sheet
Total Assets2.83M2.83M2.77M2.75M11.52M2.06M
Cash, Cash Equivalents and Short-Term Investments1.06M1.06M870.00K234.00K6.69M369.00K
Total Debt491.00K491.00K817.00K1.08M1.31M78.00K
Total Liabilities1.45M1.45M1.88M2.45M3.47M1.96M
Stockholders Equity1.38M1.38M887.00K304.00K8.05M105.00K
Cash Flow
Free Cash Flow-1.98M-2.01M-2.41M-6.09M-2.79M-1.26M
Operating Cash Flow-1.97M-2.00M-2.28M-4.06M-2.38M-1.10M
Investing Cash Flow-92.00K-92.00K-122.00K-2.03M-418.00K-339.20K
Financing Cash Flow2.28M2.28M3.04M-365.00K9.12M1.50M

Aptamer Group Plc Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price0.80
Price Trends
50DMA
0.90
Negative
100DMA
0.90
Negative
200DMA
0.68
Positive
Market Momentum
MACD
-0.01
Positive
RSI
43.89
Neutral
STOCH
22.62
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:APTA, the sentiment is Neutral. The current price of 0.8 is below the 20-day moving average (MA) of 0.94, below the 50-day MA of 0.90, and above the 200-day MA of 0.68, indicating a neutral trend. The MACD of -0.01 indicates Positive momentum. The RSI at 43.89 is Neutral, neither overbought nor oversold. The STOCH value of 22.62 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for GB:APTA.

Aptamer Group Plc Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
75
Outperform
£96.66M12.7364.40%8.33%-3.61%-6.35%
56
Neutral
£30.77M-3.69-204.29%3.31%21.91%
52
Neutral
£23.60M-6.25-213.66%39.88%81.33%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
44
Neutral
£16.88M-9.38-164.37%-11.43%23.40%
42
Neutral
£225.26M
38
Underperform
£11.80M-0.29-407.49%72.17%79.03%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:APTA
Aptamer Group Plc
0.88
0.46
108.33%
GB:AVCT
Avacta Group plc
51.50
4.00
8.42%
GB:BVXP
Bioventix
1,850.00
-1,052.78
-36.27%
GB:OBD
Oxford BioDynamics
0.28
-0.28
-50.00%
GB:FAB
Fusion Antibodies Plc
13.50
5.90
77.63%
GB:AREC
Arecor Therapeutics PLC
81.50
25.00
44.25%

Aptamer Group Plc Corporate Events

Business Operations and StrategyFinancial Disclosures
Aptamer Group Secures New Pharma Contracts and First Cash from Optimer Licensing
Positive
Jan 29, 2026

Aptamer Group has reported £190,000 of new fee-for-service contracts and extensions, largely driven by repeat Optimer® development work with top‑tier global pharmaceutical companies, lifting its FY26 fee-for-service order book to more than £2.1 million and reinforcing the growing adoption of its platform. The company also received its first £80,000 in cash licensing receipts from a non-exclusive hot‑start PCR Optimer® licence, a high-margin income stream that is expected, based on customer forecasts, to cover around 15% of annual overhead over the next three years, while additional licensing opportunities in diagnostics, tools and therapeutics, combined with a cash runway to June 2027, bolster revenue visibility and management’s confidence in ongoing growth and progress towards cash-flow break-even.

The most recent analyst rating on (GB:APTA) stock is a Hold with a £0.88 price target. To see the full list of analyst forecasts on Aptamer Group Plc stock, see the GB:APTA Stock Forecast page.

Business Operations and StrategyFinancial Disclosures
Aptamer Group Reasserts Cash Runway to June 2027 Amid Media Speculation
Positive
Jan 7, 2026

Aptamer Group plc issued a brief trading update to address media comment and speculation following an earlier announcement, reiterating that its current cash resources provide funding headroom through to June 2027. The confirmation of this cash runway aims to reassure investors and other stakeholders about the company’s near- to medium-term financial stability and its ability to continue executing its strategy without immediate need for additional financing.

The most recent analyst rating on (GB:APTA) stock is a Hold with a £1.00 price target. To see the full list of analyst forecasts on Aptamer Group Plc stock, see the GB:APTA Stock Forecast page.

Business Operations and StrategyFinancial Disclosures
Aptamer Group lifts H1 revenue 27% as licensing push builds recurring income
Positive
Jan 7, 2026

Aptamer Group reported a 27% year-on-year rise in unaudited first-half revenue to £0.83 million, backed by a fee-for-service order book of more than £2.0 million for FY26 and a £3.1 million sales pipeline, giving the board confidence that full-year revenue will materially exceed last year. The Group has accelerated its transition from development to commercialisation, signing non-exclusive licensing deals with Twist Bioscience and Alphazyme that bring immediate payments and future royalties, advancing additional licensing discussions for its Optimer® binders in diagnostics and enzymes, and securing a top-three pharmaceutical partner for radioligand development alongside substantial repeat contracts from other top-tier pharma clients. Progress with Unilever programmes, new Optimer® IHC reagents for a global diagnostics company, and a de-risked fibrotic liver therapeutic candidate collectively strengthen Aptamer’s IP base and validate its dual revenue strategy, positioning the company for higher-margin, recurring income streams and reinforcing its standing as a niche technology partner to blue-chip players across pharma, diagnostics and consumer goods.

The most recent analyst rating on (GB:APTA) stock is a Hold with a £1.00 price target. To see the full list of analyst forecasts on Aptamer Group Plc stock, see the GB:APTA Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Aptamer Group Secures Second Enzyme-Modulation Licence with Alphazyme for Hot-Start PCR Optimer
Positive
Dec 23, 2025

Aptamer Group has signed a non-exclusive worldwide OEM licensing agreement with Alphazyme, a Maravai LifeSciences company, for an enzyme‑modulating Optimer® used in hot‑start PCR and next-generation sequencing applications. The deal, which follows a successful development programme completed in late 2024, includes royalties on Alphazyme’s product sales, milestone payments, and a supply agreement under which Aptamer will manufacture the Optimer®, creating additional revenue streams and supply-chain leverage. The Optimer® binder enables temperature‑sensitive control of key enzyme activities and can replace two traditional antibodies with a single molecule, offering performance and cost advantages; this second enzyme‑modulation licence with Alphazyme is presented by Aptamer as a commercial and technical validation of its Optimer® platform and is expected to support further licensing opportunities and expansion of both companies’ product portfolios.

The most recent analyst rating on (GB:APTA) stock is a Hold with a £0.77 price target. To see the full list of analyst forecasts on Aptamer Group Plc stock, see the GB:APTA Stock Forecast page.

Business Operations and Strategy
Aptamer Group Partners with Twist Bioscience for NGS Market Expansion
Positive
Dec 16, 2025

Aptamer Group plc has entered into a non-exclusive licensing agreement with Twist Bioscience, a leader in synthetic biology and genomics, to commercialize its Optimer® binder technology in the next-generation sequencing (NGS) market. This partnership allows Aptamer to supply its proprietary binders to Twist Bioscience, maximizing the value of its intellectual property and enabling participation in the growing NGS market, projected to reach $23.6 billion by 2029. The agreement supports Aptamer’s strategy of building a licensing-led revenue model, providing sustainable income through upfront payments and royalties, while enhancing its market position alongside a proven industry leader.

The most recent analyst rating on (GB:APTA) stock is a Hold with a £0.50 price target. To see the full list of analyst forecasts on Aptamer Group Plc stock, see the GB:APTA Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Aptamer Group PLC Reports Strong Commercial Momentum and Strategic Progress
Positive
Nov 27, 2025

Aptamer Group PLC has reported significant commercial momentum and strategic progress, highlighted by contract wins with major pharmaceutical companies, resulting in a robust order book for FY26. The company has launched a Biomarker Discovery Service to enhance revenue streams and has raised £1.8 million to support operational expansion. With a focus on licensing deals and intellectual property retention, Aptamer is well-positioned for future growth and shareholder value enhancement.

The most recent analyst rating on (GB:APTA) stock is a Hold with a £0.50 price target. To see the full list of analyst forecasts on Aptamer Group Plc stock, see the GB:APTA Stock Forecast page.

Business Operations and Strategy
Aptamer Group Secures Key Contracts, Strengthening Commercial Momentum
Positive
Nov 14, 2025

Aptamer Group plc has announced significant contract wins totaling £192,000, contributing to a robust FY26 order book of £1.95 million. These contracts, including a repeat engagement with a top 5 global pharmaceutical company, highlight the company’s growing commercial momentum and the validation of its Optimer® technology. The company’s strategy of securing fee-for-service contracts while building a valuable intellectual property portfolio is proving successful, positioning Aptamer for long-term value through licensing and royalties. With strong demand from top-tier pharmaceutical companies and a replenished sales pipeline, Aptamer is confident in exceeding last year’s revenue and advancing towards therapeutic partnerships.

The most recent analyst rating on (GB:APTA) stock is a Hold with a £0.50 price target. To see the full list of analyst forecasts on Aptamer Group Plc stock, see the GB:APTA Stock Forecast page.

Business Operations and Strategy
Aptamer Group Secures Major Contract with Top Pharmaceutical Partner
Positive
Nov 4, 2025

Aptamer Group has secured a significant new contract with a top five pharmaceutical company, valued at up to £617,000, marking the third project with this partner. This contract highlights the commercial validation and increasing traction of Aptamer’s Optimer® technology platform, as it will develop binders against three key drug targets. The company retains full intellectual property rights, opening future licensing revenue opportunities. With a 46% increase in contract value visibility compared to last year, Aptamer is well-positioned for sustained revenue growth, reinforcing its foundation of repeat business with leading pharmaceutical partners.

The most recent analyst rating on (GB:APTA) stock is a Hold with a £0.50 price target. To see the full list of analyst forecasts on Aptamer Group Plc stock, see the GB:APTA Stock Forecast page.

Financial DisclosuresShareholder Meetings
Aptamer Group Announces 2025 AGM and Annual Report Release
Neutral
Nov 3, 2025

Aptamer Group plc has announced the posting of its Annual Report and Accounts for the year ending 30 June 2025, along with the Notice of its 2025 Annual General Meeting (AGM) to shareholders. The AGM is scheduled for 27 November 2025 and will be held in person, with results of voting to be announced to the London Stock Exchange and published on the company’s website.

The most recent analyst rating on (GB:APTA) stock is a Hold with a £0.50 price target. To see the full list of analyst forecasts on Aptamer Group Plc stock, see the GB:APTA Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 25, 2025