Fulcrum Therapeutics (FULC)
NASDAQ:FULC
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Fulcrum Therapeutics
(NASDAQ:FULC)
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Rating:55Neutral
Price Target:
$8.00
▼(-3.50% Downside)
Action:ReiteratedDate:04/28/26
The score reflects strong clinical momentum and multi-year liquidity runway from the latest update (supportive for future value), but is held back by weak current financial performance (no revenue, large losses, and sustained cash burn) and a softer technical picture with the stock below key moving averages. Valuation contributes only modestly given a loss-driven negative P/E and no dividend yield provided.
Positive Factors
Strong balance sheet & runway
A sizable cash position and very low leverage give Fulcrum multi-year funding visibility to advance a registration‑enabling sickle cell trial and sustain discovery work. This reduces near-term dilution risk and supports sustained clinical programs despite ongoing burn.
Negative Factors
No revenue, sustained losses & cash burn
Persistent zero revenue and large negative free cash flow mean the company remains dependent on capital markets or partnerships to fund operations. Any clinical delays or higher-than-expected development costs would increase dilution risk and could constrain the ability to advance multiple programs.
Read all positive and negative factors
Positive Factors
Negative Factors
Strong balance sheet & runway
A sizable cash position and very low leverage give Fulcrum multi-year funding visibility to advance a registration‑enabling sickle cell trial and sustain discovery work. This reduces near-term dilution risk and supports sustained clinical programs despite ongoing burn.
Read all positive factors
Fulcrum Therapeutics (FULC) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$490.42M
Dividend YieldN/A
Average Volume (3M)1.09M
Price to Earnings (P/E)―
Beta (1Y)0.99
Revenue Growth-100.00%
EPS Growth-2365.81%
CountryUS
Employees45
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-1.15
Shares Outstanding66,633,320
10 Day Avg. Volume822,437
30 Day Avg. Volume1,086,005
Financial Highlights & Ratios
PEG Ratio-0.02
Price to Book (P/B)2.05
Price to Sales (P/S)0.00
P/FCF Ratio-11.87
Enterprise Value/Market Cap0.68
Enterprise Value/RevenueN/A
Enterprise Value/Gross Profit-992.51
Enterprise Value/Ebitda-4.30
Forecast
1Y Price Target
$18.33Price Target Upside121.15% Upside
Rating ConsensusModerate Buy
Number of Analyst Covering9
EPS Forecast (FY)-1.21
Revenue Forecast (FY)N/A
Fulcrum Therapeutics Business Overview & Revenue Model
Company Description
Fulcrum Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing products for improving the lives of patients with genetically defined diseases in the areas of high unmet medical need in the United States. Its product ...
How the Company Makes Money
As a clinical-stage biotechnology company, Fulcrum Therapeutics has historically generated little to no revenue from commercial product sales and has primarily funded operations through external financing and, when applicable, collaboration-relate...
Fulcrum Therapeutics Earnings Call Summary
Earnings Call Date:Apr 27, 2026
(Q1-2026)
| % Change Since: |
Next Earnings Date:Aug 05, 2026
Earnings Call Sentiment Positive
The call conveyed strong positive clinical momentum for potociredir — notably a large, rapid increase in HbF, early VOC reduction signals and a clean safety profile — paired with a solid balance sheet and a clear plan for regulatory interactions and a potential registration-enabling trial. Offsetting risks include modestly higher operating losses and expenses, a quarterly cash decline (while runway remains into 2029), delayed availability of meaningful long-term OLE data (likely into 2027), ongoing regulatory uncertainty about surrogate endpoints and emerging competition in the oral HbF inducer space. Overall, the clinical and financial highlights outweigh the operational and regulatory uncertainties.Positive Updates
Robust HbF Increase in Phase Ib PIONEER
Potociredir 20 mg once daily produced an increase in fetal hemoglobin (HbF) from 7.1% at baseline to 19.3% at Week 12 — an absolute increase of 12.2 percentage points (≈171.8% relative increase). Additional signals included improvements in markers of hemolysis and anemia and continued progression toward pancellular HbF expression.
Negative Updates
Increased Net Loss
Net loss for Q1 2026 was $22.2 million versus $20.4 million in Q1 2025 — an increase of $1.8 million (≈8.8%), reflecting ongoing investment in development and operations.
Read all updates
Q1-2026 Updates
Positive
Negative
Robust HbF Increase in Phase Ib PIONEER
Potociredir 20 mg once daily produced an increase in fetal hemoglobin (HbF) from 7.1% at baseline to 19.3% at Week 12 — an absolute increase of 12.2 percentage points (≈171.8% relative increase). Additional signals included improvements in markers of hemolysis and anemia and continued progression toward pancellular HbF expression.
Read all positive updates
Company Guidance
Management guided that after an upcoming end‑of‑phase meeting with the FDA they will provide a trial design update later this quarter and, pending FDA feedback and final meeting minutes, plan to initiate a potential registration‑enabling trial in H2 2026 (with EMA engagement later in the year and a full PIONEER presentation planned at a medical conference in 2026); operationally they enrolled the first patient in an open‑label long‑term dosing study (targeting up to 17 U.S. patients from Cohorts 3b/4) and expect meaningful longer‑term safety and durability data in 2027 (not ASH 2026); financial guidance included cash, cash equivalents and marketable securities of $333.3M at March 31, 2026 (down $19.0M from $352.3M at 12/31/25) providing runway into 2029, and Q1 results of R&D expense $14.1M (vs $13.4M Q1 2025), G&A $8.1M (vs $7.0M), and a net loss of $22.2M (vs $20.4M); clinical metrics reiterated: 20 mg once‑daily increased HbF from 7.1% baseline to 19.3% at week 12, 7 of 12 patients had no VOCs during 12 weeks, and no treatment‑related serious adverse events were reported.Fulcrum Therapeutics Financial Statement Overview
Summary
Income Statement
18
Very Negative
Balance Sheet
72
Positive
Cash Flow
24
Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 0.00 | 0.00 | 80.00M | 2.81M | 6.34M | 19.16M |
| Gross Profit | -338.00K | -1.39M | 78.41M | 2.81M | -70.44M | -50.54M |
| EBITDA | -78.04M | -73.49M | -18.24M | -108.49M | -109.72M | -78.54M |
| Net Income | -76.12M | -74.88M | -9.72M | -97.33M | -109.87M | -80.85M |
Balance Sheet | ||||||
| Total Assets | 346.77M | 366.28M | 260.72M | 257.69M | 226.69M | 235.00M |
| Cash, Cash Equivalents and Short-Term Investments | 333.32M | 352.31M | 241.02M | 236.22M | 202.92M | 218.16M |
| Total Debt | 5.87M | 6.44M | 8.63M | 10.82M | 13.42M | 0.00 |
| Total Liabilities | 13.47M | 17.28M | 17.68M | 22.50M | 27.74M | 23.46M |
| Stockholders Equity | 333.30M | 349.00M | 243.03M | 235.19M | 198.94M | 211.54M |
Cash Flow | ||||||
| Free Cash Flow | -63.88M | -60.38M | -2.50M | -91.47M | -99.01M | -80.19M |
| Operating Cash Flow | -63.56M | -60.06M | -2.22M | -90.97M | -97.05M | -78.48M |
| Investing Cash Flow | -96.71M | 30.72M | 32.23M | -36.69M | 12.41M | -129.67M |
| Financing Cash Flow | 168.35M | 168.67M | 2.75M | 118.12M | 84.32M | 186.51M |
Fulcrum Therapeutics Technical Analysis
Neutral
8.29
Price Trends
8.41
Negative
9.75
Negative
8.84
Negative
Market Momentum
>-0.01
Negative
56.11
Neutral
84.41
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For FULC, the sentiment is Neutral. The current price of 8.29 is above the 20-day moving average (MA) of 7.50, below the 50-day MA of 8.41, and below the 200-day MA of 8.84, indicating a neutral trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 56.11 is Neutral, neither overbought nor oversold. The STOCH value of 84.41 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for FULC.
Fulcrum Therapeutics Risk Analysis
Fulcrum Therapeutics disclosed 71 risk factors in its most recent earnings report. Fulcrum Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Fulcrum Therapeutics Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
55 Neutral | $490.42M | -7.74 | -27.80% | ― | -100.00% | -2365.81% | |
54 Neutral | $1.50B | -33.72 | -15.12% | ― | 63.54% | 40.61% | |
53 Neutral | $1.88B | -8.74 | -269.56% | ― | 550.00% | -107.76% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
48 Neutral | $356.36M | -35.28 | -0.04% | ― | ― | 44.89% | |
47 Neutral | $487.14M | -3.14 | 66.23% | ― | 14.85% | 27.54% |
* Healthcare Sector Average
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Fulcrum Therapeutics Corporate Events
Business Operations and StrategyExecutive/Board ChangesFinancial Disclosures
Fulcrum Therapeutics Highlights Q1 Results and Sickle Cell Progress
Positive
Apr 27, 2026
On April 23, 2026, Fulcrum Therapeutics terminated its 2023 license agreement with CAMP4 Therapeutics covering rights to a Diamond-Blackfan anemia program, unwinding a deal that had provided Fulcrum with a worldwide exclusive license to certain sm...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.