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Amicus Therapeutics (FOLD)
NASDAQ:FOLD
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Amicus (FOLD) AI Stock Analysis

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FOLD

Amicus

(NASDAQ:FOLD)

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Neutral 62 (OpenAI - 4o)
Rating:62Neutral
Price Target:
$9.50
▲(7.10% Upside)
Amicus's strong earnings call and positive technical indicators are offset by financial risks and valuation concerns. The company's strategic growth and market expansion are promising, but high leverage and cash flow challenges remain significant risks.
Positive Factors
Revenue Growth
Consistent revenue growth indicates strong market demand and effective product adoption, supporting long-term business expansion.
Market Expansion
Expanding market access through reimbursement agreements enhances revenue potential and strengthens global market presence.
Pipeline Development
Progress in the pipeline, particularly in late-stage trials, suggests future product launches and revenue diversification.
Negative Factors
Profitability Challenges
Persistent profitability issues may hinder financial stability and limit reinvestment opportunities, impacting long-term growth.
High Leverage
Significant leverage increases financial risk, potentially constraining operational flexibility and future borrowing capacity.
Cash Flow Issues
Negative cash flow indicates challenges in funding operations internally, potentially leading to reliance on external financing.

Amicus (FOLD) vs. SPDR S&P 500 ETF (SPY)

Amicus Business Overview & Revenue Model

Company DescriptionAmicus Therapeutics, Inc. (FOLD) is a biopharmaceutical company focused on developing innovative therapies for rare and devastating diseases, particularly those caused by genetic mutations. The company operates primarily in the biotechnology sector, concentrating on the development of treatments for lysosomal storage disorders, including Fabry disease and Pompe disease. Amicus is known for its proprietary enzyme replacement therapies and small molecule pharmacological chaperones, which are designed to improve patient outcomes and quality of life.
How the Company Makes MoneyAmicus Therapeutics generates revenue primarily through the development and commercialization of its pharmaceutical products. The company earns money by selling its approved therapies directly to healthcare providers and through partnerships with larger pharmaceutical companies that may involve co-development or licensing agreements. Key revenue streams include sales of its lead products, such as Galafold (migalastat) for Fabry disease, which has been approved in various markets. Additionally, Amicus may receive milestone payments and royalties from collaborations with partners, contributing to its overall financial performance. The company's ability to secure reimbursement agreements with insurance providers and government healthcare programs also plays a critical role in its revenue generation.

Amicus Earnings Call Summary

Earnings Call Date:Nov 04, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Feb 19, 2026
Earnings Call Sentiment Positive
The earnings call for Amicus Therapeutics highlights strong financial performance with notable revenue growth and GAAP profitability, driven by their flagship products and global market expansion. Despite some increase in costs and early-stage profitability, the company's strategic focus on expanding their product pipeline and market presence suggests a positive outlook.
Q3-2025 Updates
Positive Updates
Strong Revenue Growth and GAAP Profitability
Amicus Therapeutics reported a 19% increase in total revenue over the same period in 2024, marking the first quarter of 2025 with positive GAAP net income of $17.3 million.
Galafold and Pombiliti/Opfolda Performance
Galafold revenue reached $138.3 million, up 12% at constant exchange rates and up 15% in reported terms, with a 13% year-over-year increase in patient demand. Pombiliti and Opfolda revenue reached $30.7 million, up 42% at constant exchange rates and 45% in reported terms.
Global Market Expansion
Amicus secured reimbursement in 15 countries, with new pricing and reimbursement agreements in Japan, Belgium, Ireland, and Luxembourg.
Promising Pipeline and Partnerships
Advancement of DMX-200 for FSGS, with the pivotal Phase III ACTION3 trial over 90% enrolled and on track to complete by year-end.
Negative Updates
Cost of Goods Sold Increase
Cost of goods sold as a percentage of net sales increased to 12% for Q3 compared to 9% in the same period last year.
Early Stages of Profitability
GAAP profitability may not be linear quarter-to-quarter, indicating potential volatility in achieving consistent profitability.
Company Guidance
During the Amicus Therapeutics Third Quarter 2025 Financial Results Conference Call, the company provided robust guidance across several metrics. They reported a 19% increase in total quarterly revenue, reaching $169.1 million, with Galafold revenue growing by 15% and Pombiliti and Opfolda by 42% at constant exchange rates. The company reaffirmed its full-year 2025 revenue growth guidance of 15% to 22% and projected total sales of $1 billion by 2028 for its two commercial products. Additionally, Amicus highlighted the successful enrollment of over 90% in the ACTION3 trial for DMX-200, targeting FSGS, and reiterated its confidence in achieving GAAP net income for the second half of the year. The company emphasized its strategic focus on continued revenue growth, market expansion, and new patient starts, particularly citing a 13% year-over-year increase in Galafold patient growth and a 45% revenue increase for Pombiliti and Opfolda.

Amicus Financial Statement Overview

Summary
Amicus shows strong revenue growth and gross profit margins, but low net profit margins and high leverage pose financial risks. Cash flow challenges are evident, though free cash flow covers net income.
Income Statement
65
Positive
Amicus has shown a positive trend in revenue growth with a 4.82% increase in the TTM period. The gross profit margin remains strong at approximately 89.77%, indicating efficient cost management. However, the net profit margin is relatively low at 3.32%, suggesting limited profitability. The EBIT and EBITDA margins are modest, reflecting operational challenges.
Balance Sheet
55
Neutral
The company has a high debt-to-equity ratio of 1.92, indicating significant leverage, which could pose financial risks. Return on equity is positive at 9.67%, showing some profitability for shareholders. The equity ratio is moderate, suggesting a balanced asset structure but with potential risk due to high debt levels.
Cash Flow
50
Neutral
Amicus's free cash flow growth is negative, indicating cash flow challenges. The operating cash flow to net income ratio is negative, reflecting inefficiencies in converting income to cash. However, the free cash flow to net income ratio is slightly above 1, indicating that free cash flow covers net income.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue598.70M528.29M399.36M329.23M305.51M260.89M
Gross Profit535.61M475.35M362.03M290.63M271.05M229.84M
EBITDA59.27M29.39M-92.08M-199.58M-202.87M-242.98M
Net Income-14.06M-56.11M-151.58M-236.57M-250.46M-276.85M
Balance Sheet
Total Assets868.81M785.03M777.88M724.17M905.14M886.52M
Cash, Cash Equivalents and Short-Term Investments263.84M249.95M286.20M293.60M482.50M483.27M
Total Debt442.82M443.64M445.06M452.12M440.13M441.73M
Total Liabilities638.39M590.99M617.71M601.12M597.77M600.14M
Stockholders Equity230.42M194.04M160.17M123.05M307.37M286.38M
Cash Flow
Free Cash Flow9.69M-37.44M-76.53M-170.34M-206.38M-236.52M
Operating Cash Flow12.98M-33.89M-69.09M-166.57M-202.49M-233.29M
Investing Cash Flow-60.33M-560.00K98.06M92.32M78.76M-13.58M
Financing Cash Flow-12.32M5.12M61.68M-7.46M212.07M262.86M

Amicus Technical Analysis

Technical Analysis Sentiment
Positive
Last Price8.87
Price Trends
50DMA
8.30
Positive
100DMA
7.39
Positive
200DMA
7.59
Positive
Market Momentum
MACD
0.23
Negative
RSI
57.82
Neutral
STOCH
37.67
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For FOLD, the sentiment is Positive. The current price of 8.87 is above the 20-day moving average (MA) of 8.64, above the 50-day MA of 8.30, and above the 200-day MA of 7.59, indicating a bullish trend. The MACD of 0.23 indicates Negative momentum. The RSI at 57.82 is Neutral, neither overbought nor oversold. The STOCH value of 37.67 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for FOLD.

Amicus Risk Analysis

Amicus disclosed 67 risk factors in its most recent earnings report. Amicus reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Amicus Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
83
Outperform
$2.58B12.4827.52%25.56%44.42%
62
Neutral
$2.84B-6.87%21.28%87.30%
54
Neutral
$3.02B-410.78%114.22%77.02%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
46
Neutral
$2.30B-81.83%-9.21%-8.84%
45
Neutral
$4.11B-77.58%-48.38%
43
Neutral
$3.30B-34.78%-34.96%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
FOLD
Amicus
8.87
-1.82
-17.03%
CPRX
Catalyst Pharma
21.39
-2.06
-8.78%
TVTX
Travere Therapeutics
32.34
13.31
69.94%
OCUL
Ocular Therapeutix
10.85
-0.11
-1.00%
IMVT
Immunovant
23.35
-7.79
-25.02%
IRON
Disc Medicine
83.85
17.28
25.96%

Amicus Corporate Events

Amicus Therapeutics’ Pompe Disease Study: A Potential Game-Changer for Investors
Sep 7, 2025

Amicus Therapeutics is currently recruiting for a global, prospective observational registry study titled ‘A Global Prospective Observational Registry of Patients With Pompe Disease.’ The study aims to evaluate the long-term safety, effectiveness, and impact on quality of life of treatments for Pompe disease, including both treated and untreated patients. This research is significant as it seeks to enhance understanding of the disease’s natural history and treatment outcomes.

Amicus Therapeutics’ Global Study on Pompe Disease: A Potential Game-Changer
Aug 14, 2025

Amicus Therapeutics is conducting a global, prospective observational registry study titled ‘A Global Prospective Observational Registry of Patients With Pompe Disease.’ The study aims to evaluate the long-term safety and effectiveness of treatments for Pompe disease, assess their impact on quality of life, and describe the natural history of untreated Pompe disease. This research is significant as it provides real-world data on patient outcomes.

Amicus Therapeutics’ Global Study on Pompe Disease: A Potential Game-Changer
Aug 12, 2025

Amicus Therapeutics is conducting a global observational study titled ‘A Global Prospective Observational Registry of Patients With Pompe Disease.’ The study aims to evaluate the long-term safety and effectiveness of treatments for Pompe disease, including their impact on quality of life and patient-reported outcomes. It also seeks to document the natural history of untreated Pompe disease.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 05, 2025