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Evaxion Biotech (EVAX)
NASDAQ:EVAX
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Evaxion Biotech (EVAX) AI Stock Analysis

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EVAX

Evaxion Biotech

(NASDAQ:EVAX)

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Neutral 47 (OpenAI - 4o)
Rating:47Neutral
Price Target:
$5.00
▼(-2.34% Downside)
Evaxion Biotech's overall score is driven by its strong earnings call performance, highlighting strategic achievements and financial stability. However, significant financial challenges and a negative valuation score weigh heavily on the overall assessment. Technical analysis indicates a bearish trend, further impacting the score.
Positive Factors
Revenue Growth
Strong revenue growth indicates successful product development and market acceptance, enhancing long-term financial stability.
Strategic Partnerships
Partnerships like the MSD deal validate Evaxion's technology and provide significant financial support, extending its cash runway.
AI-Driven Innovation
AI-driven innovation accelerates development timelines, improving competitive positioning and potential for new product launches.
Negative Factors
Financial Instability
Financial instability due to negative equity and high debt reliance could limit future growth and financing options.
Negative Cash Flow
Persistent negative cash flow suggests challenges in covering operational expenses, necessitating external financing for sustainability.
Market Uncertainty
Market uncertainties can delay strategic partnerships, impacting growth plans and revenue generation in the near to mid-term.

Evaxion Biotech (EVAX) vs. SPDR S&P 500 ETF (SPY)

Evaxion Biotech Business Overview & Revenue Model

Company DescriptionEvaxion Biotech (EVAX) is a biotechnology company focused on the development of innovative immunotherapies and vaccines to combat infectious diseases and cancer. Utilizing its proprietary artificial intelligence platform, Evaxion identifies and develops novel therapeutic and preventive solutions aimed at enhancing the immune response. The company operates primarily in the biopharmaceutical sector, with core products and services centered around its AI-driven drug discovery and development processes.
How the Company Makes MoneyEvaxion Biotech generates revenue through multiple streams, primarily from partnerships and collaborations with pharmaceutical companies and research institutions. These partnerships often involve co-development agreements where Evaxion provides its AI technology and expertise for drug discovery in exchange for milestone payments, royalties, and potential profit-sharing arrangements. Additionally, the company may receive funding through government grants and investments aimed at supporting the development of its vaccine and immunotherapy candidates. As Evaxion advances its product candidates through clinical trials, it has the potential to secure further investments and partnerships, enhancing its revenue opportunities.

Evaxion Biotech Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Apr 07, 2026
Earnings Call Sentiment Positive
The earnings call highlighted strong financial performance and significant advancements in R&D, including a transformative deal with MSD and promising clinical data for EVX-01. However, market uncertainties and extended evaluation periods for deals, like EVX-B2, present challenges. Overall, the achievements and financial stability significantly outweigh the challenges.
Q3-2025 Updates
Positive Updates
MSD Transformative Deal
Evaxion's first ever in-licensing of an AI discovered vaccine candidate by a major pharma company, MSD, exercised their option on EVX-B3. This included a $7.5 million exercise fee, extending the company's cash runway significantly and potentially up to $592 million in future revenue.
Strong Financial Performance
The company extended its cash runway into the second half of 2027, strengthened equity with a USD 31.8 million improvement, and recorded a quarterly operational gain for the first time. The balance sheet showed a strong cash balance of USD 10.6 million by the end of the quarter.
Clinical Efficacy of EVX-01
Presented highly encouraging two-year clinical outcome data from the EVX-01 Phase II study with a 75% objective overall response rate and a 34% conversion rate, indicating significant potential for long-term control of melanoma.
Enhanced AI-Immunology Platform
The platform was expanded with a new automated vaccine design module, significantly reducing design time and accelerating development timelines, ensuring optimal sequence and conformation of vaccine targets.
Negative Updates
Market Uncertainty Affects Partnerships
Ongoing partnership discussions are impacted by market uncertainty, which affects the deal climate and may delay potential collaborations.
Extended Evaluation Period for EVX-B2
The evaluation period for EVX-B2 was extended as MSD is conducting further confirmatory analysis, indicating potential delays in finalizing the deal.
Company Guidance
During the third-quarter 2025 call, Evaxion provided comprehensive updates on its achievements and strategic developments. Key metrics included the historical in-licensing of EVX-B3 by MSD, resulting in a $7.5 million option exercise fee, which significantly extended the company's cash runway to the second half of 2027. The company also reported a 75% overall response rate in its EVX-01 Phase II study, with 81% of vaccine neoantigens being immunogenic. Financially, Evaxion achieved a USD 4.6 million income for the quarter, driven by the MSD deal and a strong equity position of USD 16.6 million. The company highlighted its enhanced AI-Immunology platform, which includes a new automated vaccine design module, reducing design time and accelerating development timelines. Evaxion is engaged in multiple partnership discussions and aims to out-license its programs, leveraging its AI capabilities for both internal projects and potential collaborations.

Evaxion Biotech Financial Statement Overview

Summary
Evaxion Biotech shows significant revenue growth but continues to face financial challenges with persistent net losses and reliance on debt financing. The balance sheet instability and negative cash flow highlight the company's struggle to achieve sustainable profitability.
Income Statement
40
Negative
Evaxion Biotech's income statement shows a significant improvement in revenue from $73,000 in 2023 to $3,344,000 in 2024, indicating strong growth. However, the company continues to operate at a net loss, with negative EBIT and EBITDA margins, reflecting ongoing challenges in controlling operating costs and achieving profitability.
Balance Sheet
30
Negative
The balance sheet of Evaxion Biotech reveals financial instability, with negative stockholders' equity indicative of accumulated losses. The debt-to-equity ratio is undefined due to negative equity, presenting a risk. The company is heavily reliant on debt, which could challenge future financing.
Cash Flow
35
Negative
Evaxion Biotech's cash flow statements show a negative free cash flow, although there was a notable improvement in net cash provided by financing activities. The operating cash flow remains negative, suggesting the company may struggle to cover its operational expenses without external financing.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue7.65M3.34M73.00K0.000.000.00
Gross Profit7.65M3.34M73.00K0.000.000.00
EBITDA-5.96M-9.79M-21.40M-22.57M-24.21M-16.46M
Net Income-5.42M-10.57M-22.13M-23.17M-24.53M-15.02M
Balance Sheet
Total Assets29.74M12.48M12.89M22.02M40.16M11.96M
Cash, Cash Equivalents and Short-Term Investments10.57M5.05M4.18M13.18M32.17M5.83M
Total Debt0.0010.10M10.87M10.26M3.69M20.00K
Total Liabilities13.14M14.14M17.62M13.72M7.73M4.93M
Stockholders Equity16.60M-1.65M-4.73M8.30M32.44M7.04M
Cash Flow
Free Cash Flow0.00-12.94M-17.78M-26.07M-23.29M-12.83M
Operating Cash Flow0.00-12.94M-17.69M-25.77M-21.93M-12.44M
Investing Cash Flow0.00-3.00K-93.00K-268.00K-1.33M-393.00K
Financing Cash Flow0.0013.13M10.69M7.85M49.80M8.82M

Evaxion Biotech Technical Analysis

Technical Analysis Sentiment
Negative
Last Price5.12
Price Trends
50DMA
5.77
Negative
100DMA
4.31
Positive
200DMA
3.16
Positive
Market Momentum
MACD
-0.11
Positive
RSI
44.46
Neutral
STOCH
51.90
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For EVAX, the sentiment is Negative. The current price of 5.12 is below the 20-day moving average (MA) of 5.61, below the 50-day MA of 5.77, and above the 200-day MA of 3.16, indicating a neutral trend. The MACD of -0.11 indicates Positive momentum. The RSI at 44.46 is Neutral, neither overbought nor oversold. The STOCH value of 51.90 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for EVAX.

Evaxion Biotech Risk Analysis

Evaxion Biotech disclosed 117 risk factors in its most recent earnings report. Evaxion Biotech reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 3 New Risks
1.
Our failure to meet Nasdaq's continued listing requirements could result in a delisting of our ADSs. Q4, 2022
2.
Raising additional capital may cause dilution to our shareholders, restrict our operations or require us to relinquish rights to our technologies or product candidates. Q4, 2022
3.
The amount of NOLs and research and development credits and our ability to use the same to offset future taxable income may be subject to certain limitations and uncertainty. Q4, 2022

Evaxion Biotech Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
54
Neutral
$71.65M234.73%81.16%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
$34.33M4455.07%77.31%
43
Neutral
$28.44M-3071.15%36.89%43.58%
42
Neutral
$39.00M-0.87-14.92%72.81%
41
Neutral
$35.78M-4.85-83.34%-6.51%58.31%
41
Neutral
$26.58M49.57%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
EVAX
Evaxion Biotech
5.12
-2.03
-28.39%
IGC
IGC Pharma
0.31
-0.05
-13.89%
QTTB
Q32 Bio
3.41
-21.04
-86.05%
VRCA
Verrica Pharmaceuticals
6.73
-5.17
-43.45%
ELUT
Elutia
0.64
-4.11
-86.53%
NRXS
NeurAxis, Inc.
2.68
-0.39
-12.70%

Evaxion Biotech Corporate Events

Evaxion Reports Positive Data for CMV Vaccine Program
Nov 20, 2025

On November 20, 2025, Evaxion A/S announced positive data from its cytomegalovirus (CMV) vaccine program, EVX-V1. The program, which leverages Evaxion’s AI-Immunology™ platform, has identified novel antigens that significantly reduce viral infection in preclinical models. This advancement is crucial as no CMV vaccine has been approved despite decades of research, highlighting the importance of these findings. The company continues to optimize and investigate these AI-derived antigens while exploring strategic partnerships to advance the vaccine into clinical phases.

Evaxion Biotech Increases Share Capital Following Warrant Exercise
Nov 18, 2025

On November 4, 2025, Evaxion Biotech announced a share capital increase following the exercise of certain investor warrants. This resulted in the issuance of 1,875,000 ordinary shares, raising the company’s share capital to nominal DKK 104,252,689. The capital increase, registered with the Danish Business Authority, reflects a cash consideration of USD 101,625. This move is part of Evaxion’s strategic efforts to strengthen its financial position and potentially enhance its market presence.

Evaxion A/S Announces 2026 Financial Calendar
Nov 12, 2025

On November 12, 2025, Evaxion A/S announced its financial calendar for 2026, detailing key dates for business updates and financial results throughout the year. This announcement is significant for stakeholders as it outlines the company’s timeline for financial disclosures and strategic updates, which are crucial for investors and market analysts to track the company’s progress and financial health.

Evaxion Unveils New Immune Data for AI-Designed Cancer Vaccine
Nov 7, 2025

On November 7, 2025, Evaxion A/S announced new immune data from its phase 2 trial of the AI-designed personalized cancer vaccine EVX-01 at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting. The data, which builds on previous clinical efficacy results, highlights the vaccine’s ability to induce specific immune responses in patients with advanced melanoma when used in combination with Merck’s anti-PD-1 therapy, KEYTRUDA®. This development further strengthens EVX-01’s data package and underscores its potential impact on cancer treatment, drawing significant interest from the medical community.

Evaxion Biotech Announces New CEO and Promising Vaccine Developments
Nov 6, 2025

On November 6, 2025, Evaxion A/S announced significant business developments and financial results for the third quarter of 2025. Key highlights include the appointment of Dr. Helen Tayton-Martin as the new CEO, effective November 24, 2025, and the presentation of promising phase 2 trial data for their personalized cancer vaccine, EVX-01, at the ESMO Congress. The company also reported the out-licensing of their bacterial vaccine candidate, EVX-B3, to MSD, which has extended their cash runway to the second half of 2027. These developments underscore Evaxion’s strategic focus on leveraging its AI-Immunology™ platform for vaccine innovation and expanding its market presence through strategic partnerships.

Evaxion Unveils AI-Designed Cancer Vaccine Candidate EVX-04
Nov 3, 2025

On November 3, 2025, Evaxion A/S announced the expansion of its R&D pipeline with the introduction of EVX-04, a new AI-designed precision cancer vaccine candidate. EVX-04 targets non-conventional ERV tumor antigens and is designed as a therapeutic vaccine for acute myeloid leukemia. The vaccine, which induces strong T-cell responses, will be presented at the American Society of Hematology Annual Meeting in December, highlighting its potential to improve outcomes for patients who do not respond to conventional immunotherapies.

Evaxion A/S to Announce Q3 2025 Financial Results and Business Update
Oct 31, 2025

On October 31, 2025, Evaxion A/S announced it will provide a business update and report its third quarter 2025 financial results on November 6, 2025. The company will host a conference call and webcast to present the update and results, which will be open to the public. This announcement is part of Evaxion’s ongoing efforts to engage with stakeholders and provide transparency about its financial health and strategic direction.

Evaxion Biotech A/S Increases Share Capital Following Warrant Exercise
Oct 30, 2025

Evaxion Biotech A/S announced amendments to its Articles of Association following the exercise of certain investor warrants, resulting in an increase in share capital. From October 15 to October 28, 2025, the company registered a total share capital increase of nominal DKK 4,735,475, raising the total share capital to DKK 103,783,939. This move, which involved the issuance of multiple ordinary shares over several days, reflects the company’s ongoing efforts to enhance its financial standing and operational capacity, potentially impacting its market position and shareholder value.

Evaxion A/S Secures $7.2 Million to Extend Cash Runway
Oct 30, 2025

On October 30, 2025, Evaxion A/S announced it raised $7.2 million, extending its cash runway to the second half of 2027. This financial boost comes from the sale of shares and the exercise of warrants, strengthening Evaxion’s cash position and equity. The company has also reduced its outstanding warrants by 1.0 million, enhancing its financial stability. This development follows a $7.5 million payment from MSD for licensing a vaccine candidate in September 2025, further supporting Evaxion’s strategic focus on executing its R&D programs and operations.

Evaxion Appoints Dr. Helen Tayton-Martin as CEO Amid Strategic Growth
Oct 27, 2025

On October 27, 2025, Evaxion A/S announced the appointment of Dr. Helen Tayton-Martin as the new Chief Executive Officer, effective November 24, 2025. Dr. Tayton-Martin, with over 30 years of experience in biotech, including leadership roles in cancer immunotherapy, is expected to lead Evaxion’s strategic execution. Her appointment is seen as a significant step for the company, which is well-positioned for future growth with its AI-Immunology platform and recent strategic partnerships. Additionally, Jens Bitsch-Norhave will join the Board of Directors as an advisor, bringing extensive experience in corporate strategy and global expansion.

Evaxion Biotech Expands Capital Through ADS Sales and Warrant Exercises
Oct 17, 2025

On September 25, 2025, Evaxion Biotech A/S sold 1,018,000 American Depositary Shares (ADSs) in an at-the-market offering, generating approximately $4.3 million in proceeds. The company’s share capital increased significantly, with amendments to the Articles of Association reflecting these changes. Between October 3 and October 10, 2025, further share capital increases occurred due to the exercise of investor warrants, raising additional funds and expanding the company’s capital base. These financial activities are part of Evaxion’s strategic efforts to bolster its market position and operational capabilities.

Evaxion Reports 75% Response Rate in Cancer Vaccine Trial
Oct 17, 2025

On October 17, 2025, Evaxion Biotech announced impressive results from a phase 2 trial of its AI-designed personalized cancer vaccine, EVX-01, for advanced melanoma. The trial demonstrated a 75% Objective Response Rate, with 12 out of 16 patients showing clinical responses, and 92% of patients still responding after 24 months. The data, presented at the ESMO Congress, highlights the vaccine’s potential as a new treatment option and underscores the precision of Evaxion’s AI-Immunology platform in identifying neoantigens. The company plans further clinical development in partnership, marking a significant milestone in personalized immunotherapy.

Evaxion to Showcase Phase 2 Data of AI-Powered Cancer Vaccine at ESMO 2025
Oct 14, 2025

On October 13, 2025, Evaxion A/S announced that it will present comprehensive data from its phase 2 trial of the AI-designed personalized cancer vaccine, EVX-01, at the ESMO Congress 2025 in Berlin. The presentation will include two-year clinical efficacy, immunogenicity, and safety data, highlighting the vaccine’s potential in treating advanced melanoma. The trial, conducted in combination with Merck’s KEYTRUDA®, has shown promising results, including a 69% overall response rate and significant tumor-specific immune responses. This presentation underscores Evaxion’s innovative approach and strengthens its position in the personalized cancer vaccine sector.

Evaxion Unveils Automated Vaccine Design Module
Oct 8, 2025

On October 8, 2025, Evaxion A/S announced the expansion of its AI-Immunology™ platform with a new automated vaccine design module. This advancement automates previously manual processes, enhancing vaccine quality and significantly reducing design time and costs. The module is applicable for both new and existing vaccines, potentially leading to improved vaccine generations. Evaxion will present validation data on these improvements at the World Vaccine Congress Europe on October 15, 2025, highlighting its strategic focus on leading AI-based vaccine discovery and design.

Evaxion to Present New Data on AI-Designed Cancer Vaccine at SITC 2025
Oct 6, 2025

On October 3, 2025, Evaxion A/S announced that it will present new biomarker data for its AI-designed personalized cancer vaccine, EVX-01, at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting. The data, stemming from an ongoing phase 2 trial, will contribute to the strong data package of EVX-01, which is being evaluated in combination with KEYTRUDA® for advanced melanoma. The presentation aims to highlight the vaccine’s efficacy and the predictive power of Evaxion’s AI-Immunology™ platform, potentially impacting the company’s industry positioning and offering significant insights for stakeholders.

Evaxion Out-Licenses Vaccine Candidate EVX-B3 to MSD
Sep 25, 2025

On September 25, 2025, Evaxion A/S announced the out-licensing of its vaccine candidate EVX-B3 to MSD, marking a significant milestone in its strategic partnership. This agreement includes a $7.5 million cash payment to Evaxion, extending its cash runway into the first half of 2027, and potential milestone payments up to $592 million. MSD will assume full responsibility for the development of EVX-B3, while also retaining an option for a second vaccine candidate, EVX-B2, with a decision expected in the first half of 2026. This collaboration not only provides financial benefits but also validates Evaxion’s AI-Immunology™ platform, enhancing its industry positioning and potential for future partnerships.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 03, 2025