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Dyadic International (DYAI)
NASDAQ:DYAI
US Market

Dyadic International (DYAI) AI Stock Analysis

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Dyadic International

(NASDAQ:DYAI)

Rating:46Neutral
Price Target:
Dyadic International's overall score reflects significant financial challenges, notably ongoing losses and negative cash flows. While strategic partnerships and revenue growth are positive, they are offset by high leverage and operational inefficiencies. The stock's technical indicators suggest weak momentum, and its valuation remains unattractive due to unprofitability. The earnings call provides some optimism about future growth, but near-term challenges persist.

Dyadic International (DYAI) vs. SPDR S&P 500 ETF (SPY)

Dyadic International Business Overview & Revenue Model

Company DescriptionDyadic International, Inc., a biotechnology platform company, develops, produces, and sells enzymes and other proteins in the United States. The company utilizes its patented and proprietary C1 platform and other technologies to conduct research, development, and commercial activities for the development and manufacturing of human and animal vaccines and drugs, such as virus like particles and antigens, monoclonal antibodies, bi/tri-specific antibodies, fab antibody fragments, Fc-fusion proteins, biosimilars and/or biobetters, and other therapeutic enzymes and proteins. It offers DYAI-100, SARS-CoV-2-RBD antigen vaccine candidate towards a first-in-human Phase 1 clinical trial, is to validate to serve as proof of concept for the development of next generation multivariant COVID-19 vaccine candidates. The company has a research and development agreement with VTT Technical Research Centre of Finland, Ltd.; strategic research services agreement with Biotechnology Developments for Industry in Pharmaceuticals, S.L.U.; and collaboration with Syngene International Limited. Dyadic International, Inc. was founded in 1979 and is headquartered in Jupiter, Florida.
How the Company Makes MoneyDyadic International generates revenue through licensing its C1 gene expression technology to pharmaceutical and biotechnology companies. These partnerships often involve upfront payments, milestone payments, and royalties based on the commercial success of products developed using the C1 platform. The company also engages in research and development collaborations, where it provides its expertise and technology in exchange for funding. Additionally, Dyadic may generate revenue through the sale of its proprietary enzymes and other bio-based products developed using its platform.

Dyadic International Earnings Call Summary

Earnings Call Date:May 14, 2025
(Q1-2025)
|
% Change Since: -9.62%|
Next Earnings Date:Aug 06, 2025
Earnings Call Sentiment Neutral
The earnings call highlighted significant progress in Dyadic's transition towards commercializing non-pharmaceutical products and securing strategic partnerships with milestone payments. However, the call also reflected concerns over reduced collaborations and a decrease in cash reserves, alongside a consistent net loss. The focus on non-pharmaceutical commercialization and milestone achievements suggests a promising outlook despite the financial challenges.
Q1-2025 Updates
Positive Updates
Increase in Total Revenue
Total revenue for the quarter ended March 31, 2025 increased to approximately $394,000 compared to $335,000 for the same period 1 year ago.
Major Collaboration and Grant Achievements
Dyadic secured a $4.5 million grant from CEPI and a $3 million program funded by the Gates Foundation, contributing to non-dilutive funding for vaccine and antibody development.
Commercialization of Non-Pharmaceutical Products
Focus on commercial-ready non-pharmaceutical products, including the expected launch of recombinant human serum albumin in Q3 2025 and ongoing development of other enzyme products.
Strategic Partnerships and Milestone Payments
Anticipation of achieving a third milestone payment related to productivity improvements in Q2 2025.
Cost Reduction
G&A expenses decreased by 10.8% to $1,596,000 compared to $1,789,000 for the same period a year ago.
Progress in Industrial Applications
Significant progress with enzyme systems that enhance process efficiency, including a large follow-on purchase order for EN3ZYME from Fermbox Bio.
Negative Updates
Reduced Collaborations
Decrease in the number of collaborations from 9 to 4, indicating a consolidation of focus which may limit diversification.
Decreased Cash and Securities Balance
As of March 31, 2025, cash and investment grade securities were $7.4 million compared to $9.4 million as of December 31, 2024.
Net Loss
Net loss for the quarter ended March 31, 2025 was $2,028,000 or $0.07 per share compared to $2,010,000 or $0.07 per share for the same period a year ago.
Company Guidance
During the Dyadic International First Quarter 2025 Financial Results Conference Call, the guidance provided highlighted strategic shifts and upcoming initiatives aimed at driving revenue growth. The company emphasized its focus on commercializing non-pharmaceutical products across life sciences, bioactives, ingredients, and industrial sectors, leveraging its proprietary C1 and Dapibus microbial expression platforms. Dyadic anticipates launching recombinant human serum albumin in Q3 2025, targeting a $6.1 billion cell culture media market, and expects a third milestone payment in Q2 related to productivity improvements. The company is also advancing recombinant transferrin and fibroblast growth factors, with plans for Q2 sampling. In DNA/RNA tools, Dyadic is progressing with DNase1 and other enzyme prototypes targeting a $4 billion market by 2028. Furthermore, developments in animal-free dairy proteins, with a market value of $26.5 billion in 2023, include alpha-lactalbumin and human lactoferrin, with sampling efforts anticipated in late 2025. In industrial applications, Dyadic's EN3ZYME, launched in 2024, received a large follow-on order in Q1 2025. Financially, Dyadic reported Q1 2025 revenue of approximately $394,000, a net loss of $2,028,000, and cash reserves of $7.4 million as of March 31, 2025, as the company aims to support near-term revenue growth and strategic objectives.

Dyadic International Financial Statement Overview

Summary
Dyadic International faces significant financial challenges, including ongoing losses and negative cash flows. Despite some revenue growth, the company's high leverage and operational inefficiencies pose risks. However, maintaining liquidity through cash reserves is a positive aspect.
Income Statement
30
Negative
Dyadic International has shown some revenue growth over the years, with a 20.6% increase from 2023 to 2024. However, the company has consistently reported negative net income, leading to negative net profit margins. The EBIT and EBITDA margins are also negative, indicating ongoing operational challenges.
Balance Sheet
45
Neutral
The company's debt-to-equity ratio has increased significantly in 2024, indicating higher leverage and potential financial risk. The equity ratio has decreased over the years, reflecting a lower proportion of equity financing. However, the company maintains a reasonable amount of cash and short-term investments, providing some liquidity cushion.
Cash Flow
40
Negative
Operating cash flows have been negative, reflecting challenges in generating cash from operations. Free cash flow has also remained negative, though there was a notable decrease in the cash outflow in 2024 compared to previous years. The operating cash flow to net income ratio indicates a gap between reported earnings and cash generation, which may concern investors.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue3.55M3.50M2.90M2.93M2.40M1.60M
Gross Profit2.38M2.30M922.96K807.11K459.39K176.99K
EBITDA-8.47M-5.38M-8.19M-10.07M-13.07M-10.19M
Net Income-5.83M-5.81M-6.80M-9.37M-12.92M-9.33M
Balance Sheet
Total Assets7.89M9.93M8.22M13.71M21.30M30.07M
Cash, Cash Equivalents and Short-Term Investments7.35M9.26M7.26M12.64M20.26M29.09M
Total Debt5.07M5.07M136.93K0.000.000.00
Total Liabilities6.97M7.46M2.34M2.63M2.91M1.63M
Stockholders Equity923.61K2.47M5.88M11.09M18.39M28.45M
Cash Flow
Free Cash Flow-4.81M-3.97M-6.73M-8.08M-11.28M-6.57M
Operating Cash Flow-4.81M-3.97M-6.73M-8.08M-11.28M-6.57M
Investing Cash Flow-739.24K-1.88M7.45M-2.37M5.22M22.12M
Financing Cash Flow48.50K5.85M0.00543.59K1.23M255.47K

Dyadic International Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.94
Price Trends
50DMA
1.04
Negative
100DMA
1.21
Negative
200DMA
1.31
Negative
Market Momentum
MACD
-0.02
Negative
RSI
41.66
Neutral
STOCH
24.90
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For DYAI, the sentiment is Negative. The current price of 0.94 is below the 20-day moving average (MA) of 0.97, below the 50-day MA of 1.04, and below the 200-day MA of 1.31, indicating a bearish trend. The MACD of -0.02 indicates Negative momentum. The RSI at 41.66 is Neutral, neither overbought nor oversold. The STOCH value of 24.90 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for DYAI.

Dyadic International Risk Analysis

Dyadic International disclosed 41 risk factors in its most recent earnings report. Dyadic International reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Dyadic International Peers Comparison

Overall Rating
UnderperformOutperform
Sector (66)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
66
Neutral
€1.74B33.928.73%1.75%7.10%103.68%
48
Neutral
$162.14M10.83-107.28%-71.68%-397.61%
46
Neutral
$28.29M-214.26%20.58%15.90%
44
Neutral
$38.16M-45.40%4413.19%10.56%
42
Neutral
$12.00M-90.83%650.00%89.72%
41
Neutral
$48.62M-232.51%138.11%76.60%
34
Underperform
$32.59M-49.32%38.98%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
DYAI
Dyadic International
0.94
-0.50
-34.72%
IBIO
Ibio
0.74
-1.18
-61.46%
SPRO
Spero Therapeutics
2.91
1.60
122.14%
CELU
Celularity
1.98
-0.96
-32.65%
BRNS
Barinthus Biotherapeutics
0.92
-0.48
-34.29%
ANTX
AN2 Therapeutics, Inc.
1.05
-1.58
-60.08%

Dyadic International Corporate Events

Executive/Board ChangesShareholder Meetings
Dyadic International Director Arindam Bose Announces Retirement
Neutral
Apr 29, 2025

On April 28, 2025, Arindam Bose announced his decision to retire as a director of Dyadic International, Inc., effective at the company’s annual meeting on June 20, 2025. His retirement is not due to any disagreements with the company regarding its operations, policies, or practices.

Spark’s Take on DYAI Stock

According to Spark, TipRanks’ AI Analyst, DYAI is a Neutral.

Dyadic International’s overall score reflects significant financial challenges, notably ongoing losses and negative cash flows. While strategic partnerships and revenue growth are positive, they are offset by high leverage and operational inefficiencies. The stock’s technical indicators suggest weak momentum, and its valuation remains unattractive due to unprofitability. The earnings call provides some optimism about future growth, but near-term challenges persist.

To see Spark’s full report on DYAI stock, click here.

Private Placements and FinancingBusiness Operations and Strategy
Dyadic International Secures $4.5M for Vaccine Development
Positive
Mar 20, 2025

On March 20, 2025, Dyadic International announced a $4.5 million funding award from CEPI to accelerate the development of protein-based vaccines using its C1 fungus technology. The initiative aims to reduce vaccine development timelines significantly, potentially enabling vaccines to enter Phase 1 trials in just 35 days compared to the traditional four to six months. This approach could also lower production costs and increase accessibility, particularly in regions with less established manufacturing infrastructure, aligning with the global 100 Days Mission to expedite vaccine readiness against pandemic threats.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 22, 2025