Clinical DataAtumelnant was generally well tolerated with no treatment-related severe or serious adverse events, and all participants completed the 12-week treatment period.
Clinical EfficacySubstantial reductions of 60-80% in the primary hormone involved in CAH disease, serum androstenedione (A4), were seen across all 3 dose cohorts, indicating strong treatment efficacy.
Phase AdvancementBased on the positive Phase 2 readout, Crinetics plans to initiate a Phase 3 pivotal trial in the adult CAH population and also start a Phase 2b/3 pivotal trial in the pediatric CAH population.