Adverse EffectsSide effects came in higher than expectations as gastrointestinal adverse events like nausea, vomiting, diarrhea, and constipation featured prominently across all tested doses.
Discontinuation RatesDiscontinuation rates ranged from 20-38% in a largely dose-dependent manner, with the placebo arm having unusually high 18% discontinuations.
Market ReactionVKTX shares are under pressure following the data release and investor call, partly due to elevated expectations and concerns around the safety/tolerability profile of oral '2735.