Addressable Market LimitationsA small real-world population that fits the teclistamab plus daratumumab study criteria suggests limited immediate uptake for similar regimens, which may constrain overall market growth dynamics in the near term.
Competitive Pressure From BispecificsStrong clinical data for BCMA bispecific antibodies could capture market share and exert pricing and access pressure on CAR-T therapies, challenging anito-cel's commercial opportunity.
Trial Population RepresentativenessLow prior exposure to anti-CD38 therapy in key bispecific trials raises concerns about how well those trial outcomes translate to the typical second- and third-line multiple myeloma population, complicating competitive comparisons.