tiprankstipranks
Trending News
More News >
Celldex Therapeutics (CLDX)
:CLDX
Advertisement

Celldex (CLDX) AI Stock Analysis

Compare
1,221 Followers

Top Page

CLDX

Celldex

(NASDAQ:CLDX)

Rating:50Neutral
Price Target:
$23.50
▲(3.16% Upside)
Celldex's overall stock score is primarily impacted by its financial challenges, including declining revenues and persistent losses. Technical analysis provides some support with a stable upward trend, while valuation remains a concern due to negative earnings. Corporate events offer a mixed outlook, with strategic initiatives partially offsetting the halted drug development.
Positive Factors
Phase 3 Development
The safety data from the trial boosts confidence in barzolvolimab's use in ongoing Phase 3 development for chronic urticarias.
Safety and Tolerability
Barzolvolimab's safety and tolerability profile was clean with no anaphylaxis, no hypersensitivity, and no treatment-related serious adverse events.
Negative Factors
Clinical Outcomes
No symptomatic or endoscopic improvements were observed with barzolvolimab at week 12 compared to placebo.
Efficacy in Eosinophilic Esophagitis
The Phase 2 trial did not meet key endpoints on symptom improvement in eosinophilic esophagitis compared to placebo.
Program Discontinuation
The company announced the discontinuation of the EoE program.

Celldex (CLDX) vs. SPDR S&P 500 ETF (SPY)

Celldex Business Overview & Revenue Model

Company DescriptionCelldex Therapeutics, Inc., a biopharmaceutical company, engages in developing therapeutic monoclonal and bispecific antibodies for the treatment of various diseases. Its drug candidates include antibody-based therapeutics to treat patients with inflammatory diseases and various forms of cancer. The company's clinical development programs CDX-0159, a Phase I monoclonal antibody that binds the receptor tyrosine kinase KIT and inhibits its activity; CDX-1140, a human agonist monoclonal antibody targeted to CD40, a key activator of immune response, which is found on dendritic cells, macrophages, and B cells, as well as is expressed on various cancer cells; and CDX-527, a bispecific antibody, which uses the company's proprietary active anti-PD-L1 and CD27 human antibodies to couple CD27 costimulation with blockade of the PD-L1/PD-1 pathway to help prime and activate anti-tumor T cell responses through CD27 costimulation. The company has research collaboration and license agreements with University of Southampton to develop human antibodies towards CD27; Amgen Inc. with exclusive rights to CDX-301 and CD40 ligand; and Yale University. Celldex Therapeutics, Inc. was incorporated in 1983 and is headquartered in Hampton, New Jersey.
How the Company Makes MoneyCelldex generates revenue through several key streams, primarily from the development and commercialization of its therapeutic products. The company may earn revenue from product sales once its therapies receive regulatory approval and are marketed. Additionally, Celldex often engages in partnerships and collaborations with larger pharmaceutical companies, which can provide upfront payments, milestone payments as development progresses, and royalties on sales once products are commercialized. These partnerships are critical for funding research and development efforts and expanding market reach. Grant funding and research contracts may also contribute to its earnings, although product sales and collaborations remain the primary sources of revenue.

Celldex Financial Statement Overview

Summary
Celldex shows modest revenue growth but faces substantial losses with negative net income and EBIT margins. The balance sheet is strong with a high equity ratio and minimal leverage, but cash flow is challenged with negative free cash flow, indicating reliance on external funding.
Income Statement
40
Negative
Celldex shows modest revenue growth with a 7.7% increase in the most recent TTM period. However, the company is struggling with substantial losses, as evidenced by negative net income and EBIT margins. The gross profit margin remains positive at 78.6%, but the net profit margin is significantly negative at -2366.6%, indicating the company is not yet profitable. The biotechnology industry often experiences prolonged periods of negative earnings due to high R&D expenses.
Balance Sheet
50
Neutral
The balance sheet is relatively strong with a high equity ratio of 95.1%, which denotes a solid capital structure. The debt-to-equity ratio is very low at 0.005, suggesting minimal leverage. Despite these strengths, the company is facing consistent net losses, impacting its return on equity, which stands at -25.4% in the TTM period.
Cash Flow
45
Neutral
Celldex's cash flow is challenged, with a negative free cash flow of -$171.9 million in the TTM period. The operating cash flow to net income ratio is slightly positive at 0.96, indicating some alignment with reported losses. However, the free cash flow to net income ratio is negative, reflecting operational cash burn. Positive financing cash flow suggests reliance on external funding.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue5.79M7.02M6.88M2.36M4.65M7.42M
Gross Profit4.97M7.02M-111.13M-79.90M1.58M-35.12M
EBITDA-231.40M-191.90M-139.03M-104.20M-66.08M-45.64M
Net Income-199.61M-157.86M-141.43M-112.33M-70.51M-59.78M
Balance Sheet
Total Assets692.41M792.34M465.63M352.74M444.65M235.84M
Cash, Cash Equivalents and Short-Term Investments630.34M725.28M423.60M304.95M408.25M194.42M
Total Debt3.03M3.81M2.54M4.03M3.04M3.48M
Total Liabilities37.00M45.34M36.46M26.53M25.18M26.48M
Stockholders Equity655.41M747.00M429.17M326.20M419.48M209.36M
Cash Flow
Free Cash Flow-187.06M-159.70M-109.11M-105.56M-62.16M-41.96M
Operating Cash Flow-186.19M-157.78M-107.29M-103.73M-60.91M-40.40M
Investing Cash Flow164.60M-290.13M-105.78M89.94M-216.16M-98.22M
Financing Cash Flow1.89M441.45M218.46M4.08M272.37M171.23M

Celldex Technical Analysis

Technical Analysis Sentiment
Positive
Last Price22.78
Price Trends
50DMA
22.38
Positive
100DMA
21.12
Positive
200DMA
22.07
Positive
Market Momentum
MACD
0.07
Positive
RSI
51.24
Neutral
STOCH
72.38
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CLDX, the sentiment is Positive. The current price of 22.78 is above the 20-day moving average (MA) of 22.71, above the 50-day MA of 22.38, and above the 200-day MA of 22.07, indicating a bullish trend. The MACD of 0.07 indicates Positive momentum. The RSI at 51.24 is Neutral, neither overbought nor oversold. The STOCH value of 72.38 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for CLDX.

Celldex Risk Analysis

Celldex disclosed 2 risk factors in its most recent earnings report. Celldex reported the most risks in the "Legal & Regulatory" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Celldex Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
61
Neutral
$1.52B-62.99%5.90%-0.36%
51
Neutral
$7.91B-0.36-41.71%2.23%23.45%-1.86%
50
Neutral
$1.46B-27.17%-30.25%-9.70%
49
Neutral
$1.89B-705.73%87.94%57.84%
45
Neutral
$1.37B-12.82%-97.10%-96.30%
42
Neutral
$1.36B-86.86%-82.75%
39
Underperform
$1.44B-54.83%-62.51%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CLDX
Celldex
22.78
-20.98
-47.94%
TVTX
Travere Therapeutics
21.15
10.17
92.62%
VRDN
Viridian Therapeutics
18.64
4.55
32.29%
ETNB
89bio
8.61
0.14
1.65%
VERA
Vera Therapeutics
21.90
-15.30
-41.13%
JANX
Janux Therapeutics Inc
23.94
-17.32
-41.98%

Celldex Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
Celldex Halts Barzolvolimab Development for EoE
Negative
Aug 19, 2025

On August 19, 2025, Celldex Therapeutics announced results from its Phase 2 study of barzolvolimab in eosinophilic esophagitis (EoE). The study met its primary endpoint by demonstrating significant mast cell depletion in the gastrointestinal tract. However, this did not translate into improved clinical outcomes, leading Celldex to halt further development of barzolvolimab for EoE. The company remains committed to advancing barzolvolimab in other conditions where mast cells play a crucial role, such as chronic urticaria and atopic dermatitis.

Executive/Board ChangesShareholder MeetingsBusiness Operations and Strategy
Celldex Approves Equity Plan Amendment and Elects New Director
Positive
Jun 6, 2025

On June 5, 2025, Celldex Therapeutics held its Annual Meeting of Stockholders, where several key decisions were made, including the approval of an amendment to the 2021 Omnibus Equity Incentive Plan, increasing the shares available for issuance by 2,000,000. Additionally, Denice M. Torres was elected to the Board of Directors, bringing extensive leadership experience from the pharmaceutical and consumer healthcare sectors. The election of new board members and the amendment to the equity plan are expected to bolster Celldex’s strategic growth and operational capabilities as it advances its clinical programs, particularly with the promising drug barzolvolimab.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Sep 04, 2025