Celldex (CLDX) AI Stock Analysis

• Market Cap: $1.61B
• Dividend Yield: N/A
• Average Volume (3M): 591.10K
• Price to Earnings (P/E): ―
• Beta (1Y): 1.34
• Revenue Growth: -73.94%
• EPS Growth: -31.70%
• Country: US
• Employees: 186
• Sector: Healthcare
• Sector Strength: 45
• Industry: Biotechnology
• EPS (TTM): -1.01
• Shares Outstanding: 66,449,470
• 10 Day Avg. Volume: 521,235
• 30 Day Avg. Volume: 591,102
• PEG Ratio: 0.64
• Price to Book (P/B): 2.18
• Price to Sales (P/S): 231.80
• P/FCF Ratio: -10.19
• Enterprise Value/Market Cap: 0.91
• Enterprise Value/Revenue: 564.24
• Enterprise Value/Gross Profit: 823.70
• Enterprise Value/Ebitda: -5.80
• 1Y Price Target: $53.50
• Price Target Upside: 120.44% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 9
• EPS Forecast (FY): N/A
• Revenue Forecast (FY): N/A

• Rating: 53 Neutral
• Price Target: $28.00 ▲(15.37% Upside)

The score is held back primarily by weak financial performance (large losses and sustained cash burn), partially offset by a strong low-debt balance sheet. Technical indicators are mildly supportive with price above key moving averages, while valuation signals remain weak due to negative earnings and no dividend data.

Positive Factors

Innovative Pipeline

Celldex's innovative pipeline, including Barzolvolimab, showcases strong potential in immuno-oncology, enhancing its competitive edge in the biotech sector.

Leadership in Mast Cell Biology

Leadership in mast cell biology positions Celldex as a frontrunner in developing targeted therapies, potentially leading to breakthrough treatments and market differentiation.

Strategic Leadership Appointment

The appointment of an experienced CCO strengthens Celldex's commercial strategy, potentially improving market penetration and revenue generation.

Negative Factors

Declining Revenue

Declining revenue indicates challenges in product commercialization and market demand, which could hinder long-term financial stability and growth.

Persistent Losses

Persistent losses reflect operational inefficiencies and high R&D costs, posing risks to sustainability and necessitating strategic adjustments for profitability.

Weak Cash Flow

Weak cash flow limits Celldex's ability to fund operations and invest in R&D, potentially impacting its capacity to innovate and compete effectively.

Celldex Business Overview & Revenue Model

Company Description

Celldex Therapeutics, Inc., a biopharmaceutical company, engages in developing therapeutic monoclonal and bispecific antibodies for the treatment of various diseases. Its drug candidates include antibody-based therapeutics to treat patients with inflammatory diseases and various forms of cancer. The company's clinical development programs CDX-0159, a Phase I monoclonal antibody that binds the receptor tyrosine kinase KIT and inhibits its activity; CDX-1140, a human agonist monoclonal antibody targeted to CD40, a key activator of immune response, which is found on dendritic cells, macrophages, and B cells, as well as is expressed on various cancer cells; and CDX-527, a bispecific antibody, which uses the company's proprietary active anti-PD-L1 and CD27 human antibodies to couple CD27 costimulation with blockade of the PD-L1/PD-1 pathway to help prime and activate anti-tumor T cell responses through CD27 costimulation. The company has research collaboration and license agreements with University of Southampton to develop human antibodies towards CD27; Amgen Inc. with exclusive rights to CDX-301 and CD40 ligand; and Yale University. Celldex Therapeutics, Inc. was incorporated in 1983 and is headquartered in Hampton, New Jersey.

How the Company Makes Money

Celldex Therapeutics generates revenue primarily through the development and commercialization of its therapeutic products. The company has a revenue model that includes proceeds from collaborations and partnerships with larger pharmaceutical companies, which may involve upfront payments, milestone payments, and royalties on sales of approved products. Additionally, Celldex may engage in licensing agreements for its technology platforms or products, providing another stream of income. The success of its clinical trials and the subsequent approval of its therapies are critical to its earnings potential, as market demand for effective cancer treatments can significantly impact revenue. Furthermore, government grants and funding for research and development can also contribute to the company's financial resources.

Celldex Financial Statement Overview

Summary

Financials are mixed: the balance sheet is strong with minimal leverage and higher equity, but operating performance is very weak with sharply lower TTM revenue, large recurring net losses, and substantial ongoing cash burn (negative operating and free cash flow).

Income Statement

CLDX remains a deep-loss biotechnology profile. In TTM (Trailing-Twelve-Months), revenue is very small ($2.6M) and down sharply (-55% vs. the prior period provided), while losses are extremely large (net loss of ~$225M) leading to highly negative profit rates. The annual trend shows recurring losses every year (2020–2024) with profit pressure worsening versus earlier years, indicating the business is still heavily dependent on R&D spend and not operating near breakeven.

Balance Sheet

The balance sheet is a relative strength: leverage is minimal with very low debt compared with equity (debt-to-equity ~0.4% in TTM (Trailing-Twelve-Months)). Equity has grown meaningfully versus earlier years (2020–2025), which provides financial flexibility. The key weakness is negative returns on equity (TTM (Trailing-Twelve-Months) ROE roughly -33%), reflecting persistent losses and ongoing dilution/earnings drag risk if cash burn continues.

Cash Flow

Cash generation remains weak with sustained cash burn. TTM (Trailing-Twelve-Months) operating cash flow is about -$179M and free cash flow about -$182M, with free cash flow slightly worse versus the prior period (negative growth). A modest positive is that free cash flow and net income track closely (free cash flow to net income ~1.0), suggesting losses are largely reflected in cash outflows rather than being masked by accounting items—however, the absolute burn level remains the primary concern.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	2.60M	7.02M	6.88M	2.36M	4.65M	7.42M
Gross Profit	1.78M	-156.53M	-111.13M	-79.90M	-48.66M	-35.12M
EBITDA	-252.86M	-191.90M	-139.03M	-104.20M	-66.08M	-45.64M
Net Income	-224.53M	-157.86M	-141.43M	-112.33M	-70.51M	-59.78M
Balance Sheet
Total Assets	648.44M	792.34M	465.63M	352.74M	444.65M	235.84M
Cash, Cash Equivalents and Short-Term Investments	583.22M	725.28M	421.70M	304.95M	408.25M	194.42M
Total Debt	2.62M	3.81M	2.54M	4.03M	3.04M	3.48M
Total Liabilities	50.08M	45.34M	36.46M	26.53M	25.18M	26.48M
Stockholders Equity	598.36M	747.00M	429.17M	326.20M	419.48M	209.36M
Cash Flow
Free Cash Flow	-181.67M	-159.70M	-109.11M	-105.56M	-62.16M	-41.96M
Operating Cash Flow	-179.48M	-157.78M	-107.29M	-103.73M	-60.91M	-40.40M
Investing Cash Flow	177.69M	-290.13M	-105.78M	89.94M	-216.16M	-98.22M
Financing Cash Flow	1.43M	441.45M	218.46M	4.08M	272.37M	171.23M

Celldex Technical Analysis

• Technical Analysis Sentiment: Negative
• Last Price: 24.27
• 50DMA: Negative
• 100DMA: Negative
• 200DMA: Positive
• MACD: Positive
• RSI: Neutral
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CLDX, the sentiment is Negative. The current price of 24.27 is below the 20-day moving average (MA) of 25.84, below the 50-day MA of 26.53, and above the 200-day MA of 23.76, indicating a neutral trend. The MACD of -0.49 indicates Positive momentum. The RSI at 40.26 is Neutral, neither overbought nor oversold. The STOCH value of 25.04 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for CLDX.

Celldex Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
VRDN	60 Neutral	$2.90B	-8.59	-47.40%	―	23340.07%	18.06%
TVTX	56 Neutral	$2.83B	-29.21	-410.78%	―	114.22%	77.02%
VERA	56 Neutral	$2.99B	-10.72	-73.25%	―	―	-53.44%
CLDX	53 Neutral	$1.61B	-7.18	-32.44%	―	-73.94%	-31.70%
Sector *	51 Neutral	$7.86B	-0.30	-43.30%	2.27%	22.53%	-2.21%
JANX	49 Neutral	$801.77M	-7.96	-12.48%	―	-23.37%	-42.45%