Celldex's Barzolvolimab: A Promising Treatment for Eosinophilic Esophagitis with Market PotentialCelldex (Nasdaq: CLDX) plans to report topline 12-week data in the randomized, double-blind, placebo-controlled Phase 2 study tesng its KIT targeng mAb, barzolvolimab, for eosinophilic esophagis (EoE). Below we discuss the background of EoE, the epidemiology of the disorder, the study design and biologic raonale for tesng barzolvolimab, and the compev e landscape/reference Dupixent and Eohilia datasets for comparison. Given the large size of the EoE populaon (recently esmated at upwards of 472,380 cases in the US) and pricing potenal (Dupixent’s annual WAC in EoE is $95,840 given its QW dosing), we believe this could be a meaningful market opportunity for barzolvolimab, if successful. In addion, a posive readout would add support to the idea of KIT inhibitors working in a wide range of atopic condions. Brief Background on EoE.