Alto Neuroscience, Inc. (ANRO) AI Stock Analysis

• Market Cap: $112.37M
• Dividend Yield: N/A
• Average Volume (3M): 112.05K
• Price to Earnings (P/E): ―
• Beta (1Y): 1.73
• Revenue Growth: N/A
• EPS Growth: N/A
• Country: US
• Employees: 76
• Sector: General
• Sector Strength: N/A
• Industry: Biotechnology
• EPS (TTM): -0.65
• Shares Outstanding: 27,076,630
• 10 Day Avg. Volume: 101,696
• 30 Day Avg. Volume: 112,045
• PEG Ratio: N/A
• Price to Book (P/B): N/A
• Price to Sales (P/S): N/A
• P/FCF Ratio: N/A
• Enterprise Value/Market Cap: -0.54
• Enterprise Value/Revenue: -154.11
• Enterprise Value/Gross Profit: 221.60
• Enterprise Value/Ebitda: 0.95
• 1Y Price Target: $10.40
• Price Target Upside: 150.60% Upside
• Rating Consensus: Strong Buy
• Number of Analyst Covering: 7

• Rating: 42 Neutral
• Price Target: ―

Alto Neuroscience, Inc. faces significant financial challenges with zero revenue, increasing losses, and negative cash flows, reflecting in a low financial performance score. Despite some technical indicators suggesting short-term upward momentum, the stock's valuation remains risky due to a negative P/E ratio and lack of dividends, resulting in an overall low stock score.

Positive Factors

Financial Stability

The financial position is strong, with a cash runway estimated to last until 2028, which provides stability for continued operations and research.

Market Potential

The market acceptance and experience of esketamine, marketed as SPRAVATO by Johnson & Johnson, highlights potential for ANRO's offerings in treatment-resistant depression and major depressive disorder.

Pipeline Development

ANRO's pipeline includes ALTO-300, ALTO-207, and ALTO-101 with a focus on upcoming clinical catalysts.

Negative Factors

Clinical Trial Risks

The negative or mixed data readouts from CNS companies highlight the high development risk in the space.

Financial Performance

ANRO reported a net loss of $17.7M in the second quarter of 2025, reflecting financial challenges despite a strong cash position.

Product Efficacy Concerns

The lack of improvement over placebo on BL-VAS means analysts are less confident in ALTO-203's potential in MDD with anhedonia and are decreasing the probability of success to 2.5% from 5%.

Alto Neuroscience, Inc. Business Overview & Revenue Model

Company Description

Alto Neuroscience, Inc. (ANRO) is a biotechnology company focused on developing precision medicine approaches for the treatment of mental health disorders. The company leverages advancements in brain biomarkers and artificial intelligence to create personalized treatment plans for conditions such as depression and anxiety. By integrating cutting-edge neuroscience with clinical data, Alto aims to provide effective and targeted therapeutic solutions.

How the Company Makes Money

Alto Neuroscience, Inc. generates revenue through the development and commercialization of its precision medicine treatments for mental health disorders. The company's revenue model primarily involves partnerships with pharmaceutical companies and healthcare providers to co-develop and distribute its personalized treatment solutions. Additionally, Alto may leverage licensing agreements for its proprietary technology and biomarker discoveries, facilitating further revenue through royalties and milestone payments. Strategic collaborations with research institutions and involvement in clinical trials also contribute to its financial growth.

Alto Neuroscience, Inc. Financial Statement Overview

Summary

Alto Neuroscience, Inc. faces significant challenges with zero revenue generation, increasing losses, and negative cash flows. While there are improvements in equity and leverage, the company's financial performance suggests ongoing difficulties in achieving sustainable growth and profitability.

Income Statement

Alto Neuroscience, Inc. has consistently reported zero total revenue in recent years, indicating a lack of sales generation. The company has also experienced increasing net losses, with the net income deteriorating further from -$9.19 million in 2021 to -$61.43 million in 2024. The absence of revenue and consistent losses highlight significant challenges in achieving profitability.

Balance Sheet

The balance sheet shows improvement in stockholders' equity from negative values to $151.46 million in 2024, indicating better financial stability. However, the company maintains a low equity ratio given the previous negative equity and sustained liabilities. The debt-to-equity ratio has improved due to reduced debt, but historical high leverage poses potential risks.

Cash Flow

Operating cash flow remains negative, reflecting cash outflows from operations. Free cash flow is also negative, though large financing inflows ($135.69 million in 2024) have supported cash positions. Despite these inflows, the company struggles with cash generation and operational sustainability.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021
Income Statement
Total Revenue	394.00K	0.00	0.00	0.00	210.00K
Gross Profit	-274.00K	-502.00K	-373.00K	-342.00K	65.00K
EBITDA	-64.09M	-68.61M	-34.56M	-27.37M	-9.04M
Net Income	-64.86M	-61.43M	-36.30M	-27.71M	-9.19M
Balance Sheet
Total Assets	157.88M	177.54M	86.63M	50.85M	28.79M
Cash, Cash Equivalents and Short-Term Investments	147.59M	168.23M	82.55M	48.34M	25.70M
Total Debt	4.21M	16.94M	9.99M	82.11M	38.16M
Total Liabilities	34.47M	26.08M	158.30M	89.26M	41.27M
Stockholders Equity	123.41M	151.46M	-71.67M	-38.41M	-12.48M
Cash Flow
Free Cash Flow	-56.62M	-49.50M	-33.92M	-21.13M	-9.94M
Operating Cash Flow	-55.08M	-47.42M	-33.45M	-20.39M	-9.26M
Investing Cash Flow	-1.53M	-2.08M	-470.00K	-732.00K	-680.00K
Financing Cash Flow	11.11M	135.69M	68.13M	43.79M	31.69M

Alto Neuroscience, Inc. Technical Analysis

• Technical Analysis Sentiment: Positive
• Last Price: 4.15
• 50DMA: Positive
• 100DMA: Positive
• 200DMA: Positive
• MACD: Negative
• RSI: Negative
• STOCH: Negative

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ANRO, the sentiment is Positive. The current price of 4.15 is above the 20-day moving average (MA) of 3.35, above the 50-day MA of 2.90, and above the 200-day MA of 3.20, indicating a bullish trend. The MACD of 0.31 indicates Negative momentum. The RSI at 86.10 is Negative, neither overbought nor oversold. The STOCH value of 89.56 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for ANRO.

Alto Neuroscience, Inc. Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
VTGN	59 Neutral	$95.11M	―	-46.28%	―	-33.00%	54.91%
Sector *	56 Neutral	$6.56B	-1.65	0.45%	6.25%	14.92%	10.98%
MGX	50 Neutral	$70.19M	―	-37.45%	―	-39.62%	6.83%
ANRO	42 Neutral	$112.37M	―	-42.78%	―	―	―
JSPR	35 Underperform	$47.46M	―	-146.87%	―	―	-17.96%
VIGL	35 Underperform		―		―	―	3.01%
UNCY	28 Underperform	$75.06M	―	-3987.11%	―	―	68.02%

Alto Neuroscience, Inc. Corporate Events

Alto Neuroscience Announces Board Member Departures

On March 17, 2025, Alto Neuroscience announced that two of its board members, Jeff (Po Yu) Chen, Ph.D., and Maha Radhakrishnan, M.D., will not stand for re-election at the 2025 Annual Meeting of Stockholders. This decision was not due to any disagreements with the company. Following their departure, the board will reduce its size from seven to five members. Additionally, Alto Neuroscience reported its full-year 2024 financial results and highlighted significant progress in its clinical trials, including favorable interim analysis outcomes for the ALTO-300 Phase 2b MDD trial and completion of enrollment for the ALTO-203 Phase 2 trial. The company maintains a strong cash position to support its operations and upcoming clinical study readouts.