Akebia Therapeutics (AKBA)
NASDAQ:AKBA
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Akebia Therapeutics (AKBA) AI Stock Analysis

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AKBA

Akebia Therapeutics

(NASDAQ:AKBA)

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Neutral 49 (OpenAI - 4o)
Rating:49Neutral
Price Target:
Akebia Therapeutics faces significant financial challenges, including declining revenue and high leverage. However, the strong launch of Vafseo and strategic market expansion provide some optimism. Despite these positive developments, the stock remains a risk due to ongoing financial instability and valuation challenges.
Positive Factors
Product Launch Success
The strong launch of Vafseo with higher-than-expected revenue indicates effective market penetration and potential for sustained growth in the nephrology space.
Market Expansion
The broad availability of Vafseo through IRC clinics enhances market reach and supports long-term revenue growth by establishing a solid presence in the dialysis market.
Regulatory Engagement
Positive regulatory engagement for the VALOR study suggests potential future approvals, expanding treatment options and market opportunities.
Negative Factors
Financial Instability
Ongoing financial challenges, including high leverage and negative cash flow, threaten long-term stability and could hinder strategic initiatives.
Declining Product Revenue
The decline in Auryxia revenue highlights challenges in maintaining product demand, impacting overall revenue growth and profitability.
Increased Net Loss
The increase in net loss underscores financial difficulties, potentially affecting the company's ability to invest in growth and innovation.

Akebia Therapeutics (AKBA) vs. SPDR S&P 500 ETF (SPY)

Akebia Therapeutics Business Overview & Revenue Model

Company DescriptionAkebia Therapeutics, Inc. (AKBA) is a biopharmaceutical company that focuses on the development and commercialization of therapeutics for patients with kidney disease. The company operates primarily in the healthcare sector, targeting the nephrology space. Akebia's core products include vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor designed to treat anemia due to chronic kidney disease (CKD).
How the Company Makes MoneyAkebia Therapeutics makes money through the development and commercialization of pharmaceutical products for kidney-related conditions. The company's revenue model is primarily based on product sales, licensing agreements, and collaboration partnerships. Akebia generates revenue from sales of its approved therapies and through strategic partnerships with other pharmaceutical companies, which may include milestone payments and royalties. These partnerships help in the co-development, marketing, and distribution of its products, significantly contributing to its revenue streams. The company's financial performance is influenced by the regulatory approval of its products, market demand, and the competitive landscape in the biopharmaceutical industry.

Akebia Therapeutics Earnings Call Summary

Earnings Call Date:Nov 10, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 12, 2026
Earnings Call Sentiment Neutral
The earnings call reflects a mix of strong prescription growth and financial improvements, offset by operational and adherence challenges impacting Vafseo's rollout. While revenue and patient access have grown significantly, the company faces hurdles in addressing logistics and adherence issues to sustain this growth.
Q3-2025 Updates
Positive Updates
Vafseo Prescription Milestone
Vafseo has generated more total prescriptions in the first 41 weeks of launch than any recent launch in dialysis, reflecting strong reception from the dialysis community.
Significant Increase in Patient Access
Accessible patients increased from 40,000 in the first half of the year to almost 70,000 by the end of Q3, with further expansion expected with DaVita and other providers.
Revenue Growth
Total revenues increased to $58.8 million in Q3 2025 from $37.4 million in Q3 2024, with net product revenues rising to $56.8 million from $35.6 million.
Positive Financial Performance
Reported a net income of approximately $540,000 in Q3 2025 compared to a net loss of $20 million in Q3 2024, driven by increased net product revenues.
Negative Updates
Operational Challenges
Delays in aligning logistics and processes for Vafseo's delivery have impacted the speed of patient adoption, especially in transitioning to home delivery.
Adherence Issues
Lower than expected adherence rates at USRC, attributed to anemia managers switching patients back to ESA instead of titrating Vafseo dosage.
Inventory Transition Impact
The transition to 300-milligram tablets for in-center use at USRC might impact inventory levels and new patient starts in Q4 2025.
Company Guidance
During the third quarter of 2025, Akebia highlighted several key metrics and strategic developments in their financial results conference call. Vafseo, their lead product for treating anemia in dialysis patients, generated $14.3 million in revenue, with more total prescriptions in its first 41 weeks of launch than any recent dialysis launch. The company expanded accessible patient numbers from 40,000 to almost 70,000 by the end of Q3, significantly increasing prescribing access to over 260,000 patients. This growth was bolstered by a successful DaVita pilot, which extended Vafseo's availability to over 200,000 patients. Despite operational challenges, such as aligning logistics for home delivery and improving patient adherence, Akebia is working swiftly with dialysis providers to overcome these hurdles. The quarter also saw Vafseo's Win-Odds analysis from the INNO2VATE trial presented, showing a lower risk of death or hospitalization compared to ESA control, which the company expects will drive future prescribing growth. Financially, Akebia reported total revenues of $58.8 million, a significant increase from $37.4 million in the same period last year, and achieved a net income of approximately $540,000.

Akebia Therapeutics Financial Statement Overview

Summary
Akebia Therapeutics is facing financial challenges across all aspects of its financial statements. Revenue and profitability are declining, leverage is high, and cash flow is negative, posing risks to financial stability. The company needs to address these issues to improve its financial health.
Income Statement
40
Negative
Akebia Therapeutics shows a declining revenue trend with a significant reduction from previous years. Gross Profit Margin has improved, but the company remains unprofitable with negative Net Profit Margin and EBIT Margin. Overall, the income statement highlights ongoing challenges in achieving profitability.
Balance Sheet
35
Negative
The balance sheet reveals high leverage with negative stockholders' equity, indicating financial instability. The Debt-to-Equity Ratio is not calculable due to negative equity, and the company has been unable to maintain a positive Return on Equity. Equity Ratio is negative, suggesting more liabilities than assets.
Cash Flow
45
Neutral
Operating cash flow remains negative, reflecting ongoing operational cash burn. Free Cash Flow is also negative, although there is some improvement in reducing cash outflows. However, the company's ability to generate cash remains a concern, affecting overall financial health.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue225.07M160.18M194.62M292.48M211.65M294.64M
Gross Profit177.46M97.00M120.47M269.99M130.16M230.68M
EBITDA21.23M-13.72M-8.27M3.06M-189.91M-139.83M
Net Income-15.90M-69.41M-51.92M-94.23M-282.02M-384.84M
Balance Sheet
Total Assets364.15M220.67M241.70M356.05M529.35M644.14M
Cash, Cash Equivalents and Short-Term Investments166.44M51.87M42.92M90.47M149.80M269.08M
Total Debt52.58M188.73M104.18M99.78M136.05M126.28M
Total Liabilities322.56M269.86M272.29M350.82M455.34M396.52M
Stockholders Equity41.59M-49.19M-30.58M5.23M74.01M247.62M
Cash Flow
Free Cash Flow32.17M-40.69M-23.38M-73.27M-253.02M-110.70M
Operating Cash Flow32.40M-40.66M-23.38M-73.15M-252.97M-110.39M
Investing Cash Flow-51.00K-33.00K0.00-114.00K39.94M-40.00M
Financing Cash Flow100.10M49.66M-25.21M14.60M133.73M231.72M

Akebia Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.76
Price Trends
50DMA
2.68
Negative
100DMA
3.10
Negative
200DMA
2.75
Negative
Market Momentum
MACD
-0.29
Positive
RSI
30.31
Neutral
STOCH
34.55
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AKBA, the sentiment is Negative. The current price of 1.76 is below the 20-day moving average (MA) of 2.42, below the 50-day MA of 2.68, and below the 200-day MA of 2.75, indicating a bearish trend. The MACD of -0.29 indicates Positive momentum. The RSI at 30.31 is Neutral, neither overbought nor oversold. The STOCH value of 34.55 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for AKBA.

Akebia Therapeutics Risk Analysis

Akebia Therapeutics disclosed 58 risk factors in its most recent earnings report. Akebia Therapeutics reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Akebia Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
$895.42M31.9114.03%27.12%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
$490.93M32.49%65.88%
46
Neutral
$794.40M-49.06%-78.55%7.74%
41
Neutral
$1.33B-7.54-23.05%63.85%
39
Underperform
$759.04M-4.66-51.98%-75.31%
29
Underperform
$806.24M2.35%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AKBA
Akebia Therapeutics
1.76
-0.10
-5.38%
ORKA
Oruka Therapeutics
26.38
2.38
9.92%
TBPH
Theravance Biopharma
17.95
8.38
87.57%
VIR
Vir Biotechnology
5.47
-3.17
-36.69%
PROK
ProKidney
2.28
0.13
6.05%
AVBP
ArriVent BioPharma, Inc.
19.68
-8.40
-29.91%

Akebia Therapeutics Corporate Events

Private Placements and Financing
Akebia Therapeutics Announces Public Offering Pricing
Neutral
Mar 20, 2025

On March 19, 2025, Akebia Therapeutics announced the pricing of its public offering of 25 million shares of common stock at $2.00 per share, aiming to raise approximately $50 million before expenses. The offering, managed by Leerink Partners and Piper Sandler, is expected to close on March 21, 2025, and includes an option for underwriters to purchase an additional 3.75 million shares. Akebia anticipates net proceeds of $46.5 million, which could increase to $53.6 million if the additional shares are fully purchased, supporting its goal of achieving profitability.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Mar 27, 2025