Strong Full-Year Revenue Growth
Total revenues increased to $236.2M in 2025 from $160.2M in 2024, a ~47% year-over-year increase driven by the U.S. introduction of Vafseo and higher Auryxia sales.
Net Product Revenue and Launch Traction
Vafseo and Auryxia combined generated $227M in net product revenue in 2025. Vafseo net product revenue totaled $45.8M for the year ($6.2M in Q4) following commercial launch.
Growing Prescriber Base and Clinic Access
More than 1,000 prescribers across 24 dialysis organizations have written prescriptions for Vafseo; ~290,000 patients have access in dialysis clinics with protocols in place. In Q4 ~800 prescribers wrote scripts (128 were new), averaging ~10.3 prescriptions per prescriber.
Improving Adherence Metrics
First-refill adherence improved from ~75% (earlier 2025) to ~91% among the observed-dosing subset in Q4, with January early-Q1 data showing ~87% first-refill adherence in a larger observed-dosing population and sustained high 80s–90s adherence into subsequent refills.
Clinical Evidence Supporting Benefits and Cost Savings
Post-hoc INNO2VATE analysis showed lower risk of death/hospitalization vs ESA; cost comparison presented shows 7.7% lower annual hospitalization rate, 16% fewer hospitalization days and ~15% lower Medicare hospitalization costs with Vafseo, implying ~$3,700 per patient-year savings (nearly $2B/year if broadly adopted).
Material Balance Sheet Improvement
Cash and cash equivalents increased to $184.8M as of Dec 31, 2025 from $51.9M a year earlier, an increase of ~$133M, and management expects existing cash and operations to fund plans for at least two years.
Pipeline Progress and Near-Term Catalysts
Multiple clinical and pipeline milestones planned: VOCAL topline (Vafseo 3x weekly) expected late 2026, VOICE data expected early 2027, AKB-097 Phase II basket trial initiation in H2 2026 (initial data 2027), praliciguat FSGS Phase II enrolling, and AKB-9090 Phase I initiation in H1 2026 with topline later in 2026.
Improved Profitability Trends
Net loss narrowed materially to $5.3M for calendar year 2025 from $69.4M in 2024. Q4 net loss improved to $12.2M from $22.8M a year earlier, reflecting higher product revenue partially offset by investment spending.