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Aclaris Therapeutics (ACRS)
NASDAQ:ACRS

Aclaris Therapeutics (ACRS) AI Stock Analysis

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ACRS

Aclaris Therapeutics

(NASDAQ:ACRS)

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Neutral 52 (OpenAI - 5.2)
Rating:52Neutral
Price Target:
$4.00
▲(2.04% Upside)
Action:ReiteratedDate:03/12/26
The score is held back mainly by weak financial performance: sharply declining revenue, very large losses, and persistent negative free cash flow. Technicals are relatively supportive with the stock trading above key moving averages, while valuation is constrained by negative earnings and no dividend. Corporate events add a modest positive from improved funding access and early clinical progress, tempered by dilution.
Positive Factors
Low leverage / clean balance sheet
Near-zero reported debt materially reduces interest burden and financial distress risk for a clinical-stage biopharma. Low leverage preserves strategic optionality to fund trials via equity or partnerships and improves resilience against revenue volatility over the next 2–6 months.
Negative Factors
Sharp revenue decline
Top-line contraction to roughly $7.8M and ~50% YoY decline weakens the company's ability to internally fund development and magnifies reliance on external financing. Persistent revenue volatility undermines operational scalability and increases funding frequency over the medium term.
Read all positive and negative factors
Positive Factors
Negative Factors
Low leverage / clean balance sheet
Near-zero reported debt materially reduces interest burden and financial distress risk for a clinical-stage biopharma. Low leverage preserves strategic optionality to fund trials via equity or partnerships and improves resilience against revenue volatility over the next 2–6 months.
Read all positive factors

Aclaris Therapeutics (ACRS) vs. SPDR S&P 500 ETF (SPY)

Aclaris Therapeutics Business Overview & Revenue Model

Company Description
Aclaris Therapeutics, Inc. operates a clinical-stage biopharmaceutical company, develops novel drug candidates for immune-inflammatory diseases in the United States. It operates through two segments: Therapeutics and Contract Research. The Therape...
How the Company Makes Money
As a clinical-stage biopharmaceutical company, Aclaris Therapeutics primarily seeks to generate value by developing drug candidates and, if successful, monetizing them through commercialization and/or business development transactions (such as lic...

Aclaris Therapeutics Earnings Call Summary

Earnings Call Date:May 07, 2024
(Q1-2024)
|
% Change Since: |
Next Earnings Date:May 12, 2026
Earnings Call Sentiment Neutral
The earnings call highlights Aclaris' strong financial position and promising advancement of ATI-2138, despite some challenges in cash reserves and competitive landscape considerations. The company is making strategic moves in its drug development with a focus on efficiency and differentiation.
Positive Updates
Strong Financial Position
Aclaris ended the first quarter with $161 million in cash, cash equivalents, and marketable securities, with no outstanding debt. This positions the company well financially for upcoming initiatives.
Negative Updates
Decreased Cash Reserves
Cash reserves decreased from $182 million at year-end to $161 million at the end of Q1, partly due to nonrecurring payments related to discontinued programs and severance.
Read all updates
Q1-2024 Updates
Negative
Strong Financial Position
Aclaris ended the first quarter with $161 million in cash, cash equivalents, and marketable securities, with no outstanding debt. This positions the company well financially for upcoming initiatives.
Read all positive updates
Company Guidance
During the Aclaris Therapeutics Q1 2024 earnings call, several key metrics and strategic updates were provided. The company ended the first quarter with cash, cash equivalents, and marketable securities totaling $161 million, down from $182 million at the end of the previous year. Approximately $14 million of the expenditures in the first quarter were related to nonrecurring payments. Aclaris has decided to advance ATI-2138, their oral small molecule ITK JAK3 inhibitor, into a Phase II proof-of-concept study targeting atopic dermatitis. The study is designed as an open-label trial involving 15 patients over 12 weeks, with a focus on safety, pharmacokinetics (PK), and early efficacy signals. Joseph Monahan highlighted that ATI-2138 is 44.4 times more potent than ritlecitinib in blocking ITK-dependent cytokine production and 5.4 times more potent in JAK3-dependent readouts. Financially, Aclaris is committed to maintaining a strong balance sheet with ongoing cost containment initiatives and exploring business development opportunities to source nondilutive capital.

Aclaris Therapeutics Financial Statement Overview

Summary
Overall financial profile is high risk: TTM revenue fell sharply (~50% YoY) and profitability remains deeply negative (net margin ~-900%). Cash flow is consistently negative with sizable burn (TTM operating cash flow and free cash flow both about -$47M). The balance sheet is a partial offset with essentially no debt, but equity has contracted meaningfully alongside ongoing losses.
Income Statement
18
Very Negative
Balance Sheet
54
Neutral
Cash Flow
22
Negative
BreakdownDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue7.83M18.72M31.25M29.75M6.76M
Gross Profit5.74M15.93M13.17M17.79M2.05M
EBITDA-64.47M-51.72M-115.45M-84.36M-64.46M
Net Income-64.92M-132.06M-88.48M-86.91M-90.86M
Balance Sheet
Total Assets160.46M220.33M197.41M254.60M251.21M
Cash, Cash Equivalents and Short-Term Investments90.75M113.59M119.11M217.57M191.41M
Total Debt2.12M0.00426.00K684.00K693.00K
Total Liabilities57.38M64.77M40.23M56.98M53.87M
Stockholders Equity103.08M155.55M157.18M197.62M197.34M
Cash Flow
Free Cash Flow-47.11M-20.20M-79.63M-68.17M-52.44M
Operating Cash Flow-47.11M-20.07M-78.33M-67.57M-52.13M
Investing Cash Flow48.37M-69.77M46.22M12.63M-167.63M
Financing Cash Flow-5.86M74.54M26.71M72.87M225.05M

Aclaris Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price3.92
Price Trends
50DMA
3.52
Positive
100DMA
3.30
Positive
200DMA
2.59
Positive
Market Momentum
MACD
0.14
Negative
RSI
55.46
Neutral
STOCH
61.78
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ACRS, the sentiment is Positive. The current price of 3.92 is above the 20-day moving average (MA) of 3.77, above the 50-day MA of 3.52, and above the 200-day MA of 2.59, indicating a bullish trend. The MACD of 0.14 indicates Negative momentum. The RSI at 55.46 is Neutral, neither overbought nor oversold. The STOCH value of 61.78 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for ACRS.

Aclaris Therapeutics Risk Analysis

Aclaris Therapeutics disclosed 72 risk factors in its most recent earnings report. Aclaris Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Aclaris Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
52
Neutral
$470.32M-4.66-52.04%-41.87%-165.76%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
48
Neutral
$83.38M-4.40-47.69%1.06%22.41%
45
Neutral
$96.29M-2.33-138.87%78.62%32.39%
44
Neutral
$71.44M-6.57-126.62%14.08%1.34%
43
Neutral
$109.92M-5.33516.59%21.68%58.30%
42
Neutral
$8.52M-0.17-44.77%4.54%47.11%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ACRS
Aclaris Therapeutics
3.92
2.80
250.00%
NOTV
Inotiv
0.25
-1.53
-86.16%
MDXH
MDxHealth
2.27
0.67
41.87%
STIM
Neuronetics
1.43
-2.34
-62.07%
XGN
Exagen
3.04
-1.37
-31.07%
SERA
Sera Prognostics
2.14
-1.16
-35.15%

Aclaris Therapeutics Corporate Events

Business Operations and StrategyPrivate Placements and Financing
Aclaris Therapeutics Raises $20 Million in Equity Financing
Positive
Mar 12, 2026
On March 10, 2026, Aclaris Therapeutics, Inc. raised $20 million in gross proceeds through the sale of 5.7 million shares of its common stock under an amended and restated sales agreement with Leerink Partners and Cantor Fitzgerald. The shares wer...
Private Placements and FinancingRegulatory Filings and Compliance
Aclaris Therapeutics Raises Capital via Institutional Stock Sale
Positive
Mar 10, 2026
From March 2 to March 9, 2026, Aclaris Therapeutics, Inc. sold 12.7 million shares of its common stock, raising gross proceeds of $39.8 million under its amended and restated sales agreement with Leerink Partners LLC and Cantor Fitzgerald Co. The...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Mar 12, 2026