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AbSci (ABSI)
NASDAQ:ABSI
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AbSci (ABSI) AI Stock Analysis

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AB

AbSci

(NASDAQ:ABSI)

Rating:50Neutral
Price Target:
$3.00
▲(4.17%Upside)
AbSci's overall stock score reflects a challenging financial performance with significant operational inefficiencies. However, recent governance improvements and strategic initiatives in AI-driven drug discovery provide a potential path forward. Technical indicators and valuation show mixed signals, suggesting cautious optimism.
Positive Factors
Financial Performance
Absci's cash & equivalents balance as of the end of 1Q25 was ~$135M, which management estimates provides a runway into 1H27.
Partnerships
Management cited strong potential partnership interest for ABS-101, allowing for a collaboration independent of the TL1A bispecific that Absci is progressing through its early pipeline.
Technology and Innovation
Absci's AI-driven Antibody Design Model could help select antibody variants that are more human-like to mitigate potential downstream issues.
Negative Factors
Revenue
Absci reported 1Q25 revenues of $1.2M, which fell short of the consensus estimate of $2.6M.
Risks
Risks to the Buy rating include potential issues with partnerships, technology, clinical and regulatory challenges, and competition.

AbSci (ABSI) vs. SPDR S&P 500 ETF (SPY)

AbSci Business Overview & Revenue Model

Company DescriptionAbsci Corporation, a drug and target discovery company, provides biologic drug candidates and production cell lines using integrated drug creation platform for partners in the United States. Its integrated drug creation platform enables the creation of biologics by unifying the drug discovery and cell line development processes into one process. Absci Corporation was founded in 2011 and is headquartered in Vancouver, Washington.
How the Company Makes MoneyAbSci generates revenue primarily through collaborations and partnerships with pharmaceutical and biotechnology companies. These partnerships typically involve research and development agreements where AbSci provides its expertise and technology to help partners discover, design, and optimize protein-based drugs. The company earns money through upfront payments, milestone payments, and royalties based on the success and commercialization of the therapeutics developed using its platform. Additionally, AbSci may offer contract services for specific research and development projects, contributing further to its revenue streams.

AbSci Earnings Call Summary

Earnings Call Date:May 13, 2025
(Q1-2025)
|
% Change Since: -2.70%|
Next Earnings Date:Aug 19, 2025
Earnings Call Sentiment Positive
The earnings call highlighted significant milestones, including the initiation of clinical trials and a robust financial position. Despite increased expenses and modest revenue, the company's strategic focus on AI-driven drug discovery and potential partnerships indicates a positive outlook.
Q1-2025 Updates
Positive Updates
Initiation of First-in-Human Clinical Trial
Absci initiated its first-in-human clinical trial for ABS-101, marking its transition to a clinical-stage biotech company. The trial focuses on safety and tolerability, with interim results expected later this year.
Strong Financial Position
Absci ended the quarter with $134 million in cash, cash equivalents, and short-term investments, up from $112.4 million at the end of 2024. The company expects these funds to support operations into the first half of 2027.
AI-Driven Drug Discovery Advancements
Absci's generative AI platform continues to accelerate the development of therapeutics, with promising progress in AI-designed antibodies for unmet medical needs.
Partnership and Collaboration Prospects
Absci anticipates signing one or more drug creation partnerships this year, including with a large pharma company, leveraging its AI platform.
Negative Updates
Increased Expenses
Research and development expenses increased to $16.4 million from $12.2 million in the prior year period, driven by internal program advancements and increased personnel and stock compensation expenses.
Modest Revenue
Revenue for the first quarter was $1.2 million, reflecting the early-stage nature of Absci's programs and the focus on progressing partner programs.
Company Guidance
In the recent call, Absci provided detailed guidance on their progress and future plans. The company announced the initiation of their first-in-human clinical trial for ABS-101, which is now in a Phase I study involving approximately 40 healthy adult volunteers. The trial aims to evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD), with interim results expected later this year. Additionally, Absci is advancing ABS-201, an anti-prolactin receptor antibody, with a Phase I trial slated for early 2026 and interim efficacy data by the end of that year. The company reported Q1 2025 revenue of $1.2 million, with R&D expenses at $16.4 million, up from $12.2 million the previous year, and SG&A expenses at $9.5 million. Absci ended the quarter with $134 million in cash and short-term investments, projecting sufficient funding into the first half of 2027. The company also expressed optimism about potential partnerships, including with large pharmaceutical companies, and emphasized their commitment to leveraging AI for drug discovery.

AbSci Financial Statement Overview

Summary
AbSci is struggling with profitability and cash flow generation, as evidenced by negative margins and cash flow metrics. The balance sheet remains relatively stable, with a solid equity base and low leverage, but operational inefficiencies and growth challenges present substantial risks that need to be addressed to improve financial health.
Income Statement
35
Negative
The income statement reveals persistent revenue stagnation and consistent net losses. The Gross Profit Margin and Net Profit Margin are negative, highlighting ongoing operational challenges. Revenue growth remains unstable with a decline in recent periods, while negative EBIT and EBITDA margins indicate significant operational inefficiencies.
Balance Sheet
45
Neutral
The balance sheet shows a strong equity position with a low debt-to-equity ratio, indicating financial leverage is not a major concern. However, the continued net losses impede returns, as evidenced by the negative ROE. The equity ratio is relatively stable but has been decreasing, reflecting potential asset allocation challenges.
Cash Flow
40
Negative
Operating Cash Flow remains negative, reflecting ongoing cash burn, while Free Cash Flow also faces significant challenges. The company’s cash flow from operations compared to net income shows issues in converting income into cash, despite positive financing activities in recent periods providing liquidity support.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue4.53M5.72M5.75M4.78M4.78M
Gross Profit-8.86M-41.85M-7.29M-1.87M-6.67M
EBITDA-89.08M-95.46M-91.36M-99.77M-12.59M
Net Income-103.11M-110.57M-104.90M-100.96M-14.57M
Balance Sheet
Total Assets213.61M217.30M321.01M426.19M88.57M
Cash, Cash Equivalents and Short-Term Investments112.42M97.66M164.43M252.57M69.87M
Total Debt10.11M15.96M22.98M20.01M14.50M
Total Liabilities34.48M41.12M46.59M60.09M178.00M
Stockholders Equity179.13M176.18M274.41M366.11M-89.43M
Cash Flow
Free Cash Flow-72.81M-65.50M-97.51M-98.64M-13.15M
Operating Cash Flow-72.40M-64.64M-81.34M-60.60M-10.97M
Investing Cash Flow-41.58M81.94M-126.98M-67.38M-2.17M
Financing Cash Flow82.53M-4.48M5.24M336.19M70.97M

AbSci Technical Analysis

Technical Analysis Sentiment
Positive
Last Price2.88
Price Trends
50DMA
2.77
Positive
100DMA
2.91
Negative
200DMA
3.30
Negative
Market Momentum
MACD
-0.02
Negative
RSI
56.24
Neutral
STOCH
50.40
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ABSI, the sentiment is Positive. The current price of 2.88 is above the 20-day moving average (MA) of 2.71, above the 50-day MA of 2.77, and below the 200-day MA of 3.30, indicating a neutral trend. The MACD of -0.02 indicates Negative momentum. The RSI at 56.24 is Neutral, neither overbought nor oversold. The STOCH value of 50.40 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for ABSI.

AbSci Risk Analysis

AbSci disclosed 83 risk factors in its most recent earnings report. AbSci reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

AbSci Peers Comparison

Overall Rating
UnderperformOutperform
Sector (46)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
78
Outperform
$641.51M15.1320.50%2333.50%
UPUPB
64
Neutral
$587.43M
63
Neutral
$699.35M-204.78%44.92%-40.06%
50
Neutral
$349.51M-48.98%-9.95%20.78%
46
Neutral
C$197.02M-3.33-23.14%2.65%20.75%-0.36%
40
Underperform
$211.52M87.26%-43.76%
33
Underperform
$976.65M-71.44%19.94%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ABSI
AbSci
2.88
-1.09
-27.46%
OMER
Omeros
3.48
-1.40
-28.69%
ZVRA
Zevra Therapeutics
12.66
6.61
109.26%
STOK
Stoke Therapeutics
12.35
-1.23
-9.06%
SANA
Sana Biotechnology
4.45
-1.35
-23.28%
UPB
Upstream Bio, Inc.
11.04
-12.34
-52.78%

AbSci Corporate Events

Executive/Board Changes
AbSci Appoints Mary Szela to Board of Directors
Neutral
Jul 8, 2025

On July 7, 2025, Absci Corporation appointed Mary Szela to its Board of Directors, expanding the board to seven members. Ms. Szela, who is also the CEO, President, and Director of Trisalus Life Sciences, will serve as a Class III director until the 2027 annual meeting. She was granted an option to purchase 178,400 shares of the company’s stock, which will vest monthly over three years, and will receive an annual $40,000 cash retainer.

The most recent analyst rating on (ABSI) stock is a Buy with a $7.00 price target. To see the full list of analyst forecasts on AbSci stock, see the ABSI Stock Forecast page.

Executive/Board ChangesShareholder Meetings
Absci Elects New Board Members at Annual Meeting
Positive
Jun 12, 2025

On June 11, 2025, Absci Corporation held its Annual Meeting of Stockholders, where shareholders voted to elect Frans van Houten and Karen McGinnis as Class I board members and ratified Ernst & Young LLP as the independent accounting firm for 2025. The approval of these proposals is expected to strengthen Absci’s governance and financial oversight, potentially enhancing its industry positioning and stakeholder confidence.

The most recent analyst rating on (ABSI) stock is a Buy with a $7.00 price target. To see the full list of analyst forecasts on AbSci stock, see the ABSI Stock Forecast page.

Product-Related AnnouncementsBusiness Operations and StrategyFinancial Disclosures
Absci Initiates First Human Study for ABS-101
Neutral
May 13, 2025

On May 13, 2025, Absci Corporation announced the initiation of its first-in-human study for ABS-101, marking its transition to a clinical-stage biotech company. The company also shared promising preclinical data for ABS-201, indicating potential for a more effective treatment for androgenetic alopecia. Financially, Absci reported a net loss of $26.3 million for Q1 2025, with cash reserves expected to fund operations into the first half of 2027. The company’s strategic focus remains on advancing its internal pipeline and expanding partnerships, with anticipated new collaborations in 2025.

The most recent analyst rating on (ABSI) stock is a Buy with a $7.00 price target. To see the full list of analyst forecasts on AbSci stock, see the ABSI Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 18, 2025