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AbSci (ABSI)
NASDAQ:ABSI
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AbSci (ABSI) AI Stock Analysis

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ABSI

AbSci

(NASDAQ:ABSI)

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Neutral 43 (OpenAI - 4o)
Rating:43Neutral
Price Target:
$2.50
▼(-9.75% Downside)
AbSci's overall stock score is primarily impacted by its financial challenges, including unprofitability and cash flow issues. Technical analysis supports a bearish outlook, while valuation metrics indicate unattractiveness. However, the earnings call provides a more positive outlook with strategic pipeline developments and potential partnerships.
Positive Factors
Pipeline Expansion
The expansion of ABS-201 into AGA and endometriosis represents a strategic focus on high-potential markets, enhancing long-term growth prospects.
Financial Position
A strong cash position provides financial stability and supports ongoing R&D efforts, enabling strategic investments and partnerships.
AI-Driven Drug Discovery
Leveraging AI for drug discovery enhances innovation and competitive edge, potentially leading to unique therapeutic solutions and partnerships.
Negative Factors
Unprofitability
Persistent unprofitability and cash burn pose risks to sustainability, limiting the company's ability to invest in growth and innovation.
High R&D Expenses
Rising R&D expenses strain financial resources, potentially impacting profitability and necessitating efficient resource allocation.
Challenges with ABS-101
Development challenges with ABS-101 may hinder progress and necessitate partnerships, affecting the timeline and success of product commercialization.

AbSci (ABSI) vs. SPDR S&P 500 ETF (SPY)

AbSci Business Overview & Revenue Model

Company DescriptionAbSci (ABSI) is a biotechnology company specializing in the development of innovative solutions for protein production and drug development. The company focuses on utilizing its proprietary platform, which combines advanced cell-free protein synthesis technology with synthetic biology, to create high-quality proteins for various applications in the pharmaceutical and biotechnology sectors. AbSci’s core offerings include its contract development and manufacturing services, as well as its proprietary pipeline of therapeutic proteins aimed at addressing unmet medical needs.
How the Company Makes MoneyAbSci generates revenue primarily through its contract development and manufacturing services, where it collaborates with pharmaceutical and biotech companies to produce proteins for research and therapeutic purposes. This includes providing services for protein engineering, optimization, and large-scale production. Additionally, AbSci earns revenue from partnerships and collaborations with major pharmaceutical companies, where it may receive milestone payments and royalties based on the success of developed products. The company's proprietary pipeline of therapeutic proteins also has the potential to contribute to revenue through licensing agreements or direct sales once products are commercialized.

AbSci Earnings Call Summary

Earnings Call Date:Nov 12, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 24, 2026
Earnings Call Sentiment Positive
The earnings call highlighted Absci Corporation's strategic focus on expanding its pipeline and leveraging its AI platform for drug discovery. Significant progress was made in the development of ABS-201, with promising market opportunities in AGA and endometriosis. Despite challenges with ABS-101, the company remains financially robust and anticipates new partnerships, indicating a positive outlook.
Q3-2025 Updates
Positive Updates
Pipeline Expansion and Strategic Focus
Absci Corporation is accelerating the development of ABS-201 in androgenetic alopecia (AGA) and expanding into endometriosis. The phase 1/2a trial for AGA is expected to start in December 2025, with proof of concept readouts anticipated in 2026 and 2027 for AGA and endometriosis, respectively.
Financial Position and Partnerships
Cash, cash equivalents, and marketable securities increased to $152.5 million as of 09/30/2025. Absci anticipates signing one or more drug creation partnerships, including with a large pharma company, by year-end.
Positive Interim Results for ABS-101
Interim results for ABS-101 showed extended half-life compared to first-generation competitors and a favorable safety profile with no serious adverse events.
Focus on AI-Driven Drug Discovery
Absci continues to expand its AI platform capabilities, generating interest in partnerships and enabling the creation of a unique pipeline of therapeutic programs.
Negative Updates
Challenges with ABS-101 Development
ABS-101 did not achieve the desired half-life compared to next-generation competitors, leading to the decision to seek a partner for its further development.
High R&D Expenses
Research and development expenses increased to $19.2 million for the quarter ended 09/30/2025, primarily due to the advancement of internal programs.
Company Guidance
During the Absci Corporation Q3 2025 business update call, significant guidance was provided on the company's ongoing and future projects. The call highlighted the interim phase one results for ABS-101, noting extended half-life compared to first-generation competitors but not next-generation ones, with a favorable safety profile and no serious adverse events reported. The development of ABS-201 for androgenetic alopecia (AGA) is ahead of schedule, with a phase 1/2a trial set to commence in December 2025 and an interim proof of concept readout expected in 2026. Additionally, ABS-201's development is expanding into endometriosis, with a phase two proof of concept clinical trial anticipated in 2026. The company aims to partner ABS-101 and reallocate resources towards ABS-201 due to its potential in treating conditions with significant unmet need and the multibillion-dollar market opportunities they present. Financially, Absci reported Q3 2025 revenues of $400,000, R&D expenses of $19.2 million, and SG&A expenses of $8.4 million, with cash and equivalents at $152.5 million as of September 30, 2025, projecting operational funding into 2028.

AbSci Financial Statement Overview

Summary
AbSci faces significant financial challenges, with persistent unprofitability and cash flow issues. The income statement shows negative margins, and the cash flow analysis reveals cash burn. Despite low leverage, the company's inability to generate positive returns and cash flow poses risks.
Income Statement
25
Negative
AbSci's income statement reflects significant challenges, with negative gross and net profit margins indicating unprofitability. The TTM data shows a sharp decline in revenue growth, exacerbating the financial strain. The company is struggling to convert revenue into profit, as evidenced by negative EBIT and EBITDA margins.
Balance Sheet
40
Negative
The balance sheet shows a relatively low debt-to-equity ratio, suggesting limited leverage, which is a positive aspect. However, the negative return on equity indicates that the company is not generating returns for shareholders, and the equity ratio suggests a high reliance on equity financing.
Cash Flow
30
Negative
Cash flow analysis reveals negative operating and free cash flows, indicating cash burn. Although there is a slight improvement in free cash flow growth, the operating cash flow to net income ratio is negative, highlighting inefficiencies in cash generation relative to net income.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue2.81M4.53M5.72M5.75M4.78M4.78M
Gross Profit-50.98M-57.92M-41.85M-53.16M-39.80M-6.67M
EBITDA-103.91M-94.10M-79.68M-93.71M-67.68M-12.59M
Net Income-114.60M-103.11M-110.57M-104.90M-100.96M-14.35M
Balance Sheet
Total Assets244.99M213.61M217.30M321.01M426.19M88.57M
Cash, Cash Equivalents and Short-Term Investments152.47M112.42M97.66M164.43M252.57M69.87M
Total Debt6.22M10.11M15.88M22.98M20.01M14.50M
Total Liabilities34.65M34.48M41.12M46.59M60.09M21.56M
Stockholders Equity210.34M179.13M176.18M274.41M366.11M67.00M
Cash Flow
Free Cash Flow-81.94M-72.81M-65.50M-97.51M-98.64M-13.15M
Operating Cash Flow-80.71M-72.40M-64.64M-81.34M-60.60M-10.97M
Investing Cash Flow-50.66M-41.58M81.94M-126.98M-67.38M-2.17M
Financing Cash Flow103.09M82.53M-4.48M5.24M336.19M70.97M

AbSci Technical Analysis

Technical Analysis Sentiment
Negative
Last Price2.77
Price Trends
50DMA
3.52
Negative
100DMA
3.15
Negative
200DMA
3.16
Negative
Market Momentum
MACD
-0.29
Positive
RSI
34.58
Neutral
STOCH
21.56
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ABSI, the sentiment is Negative. The current price of 2.77 is below the 20-day moving average (MA) of 3.58, below the 50-day MA of 3.52, and below the 200-day MA of 3.16, indicating a bearish trend. The MACD of -0.29 indicates Positive momentum. The RSI at 34.58 is Neutral, neither overbought nor oversold. The STOCH value of 21.56 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for ABSI.

AbSci Risk Analysis

AbSci disclosed 83 risk factors in its most recent earnings report. AbSci reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

AbSci Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
53
Neutral
$617.06M-45.38%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
48
Neutral
$338.00M-60.52%407.86%30.14%
47
Neutral
$497.99M6.35%39.57%
47
Neutral
$355.36M-5.58-29.83%-40.26%
43
Neutral
$430.06M-55.68%-33.09%3.38%
39
Underperform
$708.83M-2.01-85.37%50.23%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ABSI
AbSci
2.77
0.21
8.20%
AUTL
Autolus Therapeutics
1.23
-1.71
-58.16%
RAPT
RAPT Therapeutics
27.28
18.64
215.74%
ADCT
ADC Therapeutics
3.99
2.00
100.50%
FDMT
4D Molecular Therapeutics
10.34
2.55
32.73%
DSGN
Design Therapeutics
7.87
2.25
40.04%

AbSci Corporate Events

Absci Corp’s Earnings Call Highlights Strategic Growth
Nov 14, 2025

Absci Corporation’s recent earnings call conveyed a positive sentiment, emphasizing the company’s strategic focus on expanding its pipeline and leveraging its AI platform for drug discovery. The company reported significant progress in the development of ABS-201, with promising market opportunities in androgenetic alopecia (AGA) and endometriosis. Despite some challenges with ABS-101, Absci remains financially robust and anticipates forming new partnerships, indicating a positive outlook.

Absci Corporation Advances AI-Driven Therapeutics
Nov 13, 2025

Absci Corporation is a clinical-stage biopharmaceutical company leveraging generative AI to advance breakthrough therapeutics, focusing on biologics for challenging therapeutic targets.

Business Operations and StrategyFinancial Disclosures
Absci Reports Q3 Results, Focuses on ABS-201
Neutral
Nov 12, 2025

On November 12, 2025, Absci Corporation reported its third-quarter financial and operating results, highlighting significant advancements in its pipeline. The company is focusing on ABS-201, targeting androgenetic alopecia and endometriosis, with clinical trials scheduled for late 2025 and 2026. Absci’s strategic shift involves reallocating resources to ABS-201 due to its high unmet medical need and market potential, while exploring partnerships for ABS-101. The company reported a net loss of $28.7 million for the quarter but has sufficient cash reserves to fund operations until the first half of 2028.

The most recent analyst rating on (ABSI) stock is a Hold with a $4.00 price target. To see the full list of analyst forecasts on AbSci stock, see the ABSI Stock Forecast page.

Financial DisclosuresM&A Transactions
Absci Finalizes Milestone Distribution Agreement with SBGH
Neutral
Nov 4, 2025

On October 31, 2025, Absci Corporation executed a Letter Agreement with SBGH, LLC, amending a previous Merger Agreement from June 4, 2021, involving Totient, Inc. This agreement finalizes the distribution of Milestone Consideration, with former Totient stockholders receiving approximately $7.6 million and Absci receiving about $8.7 million, impacting the financial settlements under the original merger terms.

The most recent analyst rating on (ABSI) stock is a Hold with a $4.50 price target. To see the full list of analyst forecasts on AbSci stock, see the ABSI Stock Forecast page.

Absci Corp. Earnings Call: Strategic Gains Amid Challenges
Sep 1, 2025

Absci Corp. recently held its earnings call, showcasing a mixed sentiment. The company reported significant progress in clinical trials and strategic partnerships, which are pivotal in strengthening its financial position and enhancing its drug development capabilities. However, challenges such as increased R&D expenses and low revenue figures were also highlighted, indicating areas that need attention.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Nov 14, 2025