Strong Q1 Revenue Beat
Total revenue of $400 million in Q1 2026, coming in above guidance and representing a $300 million increase versus prior year (≈+300% YoY). Geographic mix ~80% international / 20% U.S.
Reiterated 2026 Revenue Growth Target
Company reiterated full-year revenue growth guidance of up to 10% for 2026, supported by long‑term strategic partnerships (UK, Canada, Australia) and continued mNEXSPIKE growth.
Material Cost Discipline and Cash Cost Reduction
Adjusted cash cost decreased 26% YoY in Q1 (excluding the litigation settlement). Company remains on track to achieve ~ $4.2 billion adjusted cash costs for full-year 2026.
Non-GAAP Profitability Improvement
Excluding the litigation settlement, net loss would have been $0.5 billion ($1.18 per share), down over 50% versus prior year, reflecting improved operating performance.
Operating Expense Reductions
R&D expenses fell to $649 million (down 24% YoY) as large Phase III respiratory programs and CMV Phase III wind down; SG&A expenses were $173 million (down 18% YoY), reflecting continued cost discipline.
Regulatory and Clinical Milestones
Secured two EU approvals: mNEXSPIKE (COVID vaccine for 12+) and the world's first flu+COVID combo vaccine (approved in EU for adults 50+). Initiated Phase III for Intismeran in Stage 1 NSCLC (monotherapy arm) and Phase III start for pandemic flu program mRNA-1018; norovirus Phase III fully enrolled for its second Northern Hemisphere season with data expected in 2026.
Product Portfolio Expansion and Approvals
Now have four approved products in infectious disease portfolio (including RSV and COVID products). mRNA-1010 (seasonal flu) has U.S. PDUFA date of August 5, 2026; additional filings planned to expand global access to mNEXSPIKE.
Strong Balance Sheet and Cash Planning
Ended Q1 with $7.5 billion in cash and investments; updated 2026 year-end cash target of $4.5–$5.0 billion and projected capex of $0.2–$0.3 billion, reflecting planned investment and liquidity runway.