Record Quarterly and Annual Revenue
Q4 2025 total revenue of $92.9M, up 23% year-over-year; full year 2025 total revenue of $276.3M, above the high end of guidance.
MACI Franchise Momentum
MACI Q4 revenue of $84.1M, up 23% year-over-year and +51% sequential vs. Q3; full year MACI revenue $239.5M, up 21% YoY; MACI has delivered ~24% CAGR over 9 years and 20%+ growth in each of the last 3 years; over 20,000 patients treated to date.
Strong Profitability and Margin Expansion
Q4 gross profit >$73M representing ~79% gross margin and adjusted EBITDA >$37M (40% margin) — highest quarterly margins to date; full year gross margin 74% (up ~200 bps YoY) and adjusted EBITDA margin 26% (up >300 bps YoY).
Solid Cash Position and Cash Generation
Ended 2025 with approximately $200M in cash and investments (increase of $35M in H2) and generated $52M of operating cash flow for the full year; no debt.
Commercial Expansion: Sales Force and MACI Arthro Training
Completed MACI sales force expansion (≈30% territory expansion, ~30 new reps) and trained ~1,000 surgeons on MACI Arthro; MACI Arthro-trained and implanting surgeons show higher biopsy and implant growth and higher conversion rates.
Clinical and Product Development Progress
Initiated Phase III MACI Ankle (MASCOT) clinical study in Q4 2025; on track to begin commercial manufacturing at new Burlington facility in 2026 and pursuing staged OUS expansion with planned MHRA submission mid-2026 and potential U.K. launch in 2027.
Clear 2026 Financial Guidance with Upside Potential
2026 guidance: total revenue $316M–$326M; MACI $280M–$286M; Burn Care ~$36M–$40M; full year gross margin ~75% and adjusted EBITDA margin ~27%; Q1 MACI guide $54M–$55M and Burn Care $9M–$10M with expected >20% company revenue growth in Q1.
Burn Care Performance and Cross-Selling
Burn Care Q4 revenue $8.8M (above guidance); full year Burn Care revenue $36.8M (Epicel $32.1M, NexoBrid $4.7M); Burn Care team consolidated (17 territories) cross-selling both products, with NexoBrid orders from >70 of ~90 target accounts.