Strong Top-Line Growth
Total revenues of EUR 7.7 billion in FY2025, up 26% (29% at constant exchange rates); net sales near EUR 7.4 billion, up 32% (35% at constant exchange rates).
Five Growth Drivers Doubling Contribution
The five growth drivers reached EUR 3.3 billion in 2025 — more than double the revenue they delivered in the prior year — with BIMZELX contributing >EUR 2.2 billion.
BIMZELX Commercial Momentum
BIMZELX net sales >EUR 2.2 billion in 2025, approved in 50+ countries, treated >116,000 patients; dynamic patient share ~30% in psoriasis, ~20% in rheumatology, ~45% in HS; U.S. HS market share ~32% (up from ~25% in July).
Significant Profitability Expansion
Adjusted gross profit EUR 6.1 billion (up 27%), gross margin 79.2%; adjusted EBITDA EUR 2.6 billion (up 79%, 87% at constant FX) with EBITDA margin up 10 percentage points to 34%; group profit EUR 1.6 billion (vs EUR 1.1 billion prior year).
EPS and Cash / Balance Sheet Strength
Core EPS EUR 9.99, roughly doubled year-over-year. Strong cash generation allowed the company to fully deleverage the balance sheet and reduce net financial expenses to EUR 126 million.
Pipeline and Regulatory Milestones
KYGEVVI received U.S. approval and positive CHMP opinion (TK2 deficiency) with U.S. launch planned Q1 2026; two bispecifics in atopic dermatitis met primary endpoints and UCB is prioritizing galvokimig; bepranemab (anti-tau) achieved positive Phase II and received FDA fast-track designation.
Clinical & Development Momentum
Upcoming/accelerated readouts and starts: BE BOLD psoriatic arthritis results moved earlier to H1 2026; FINTEPLA headed to Rett syndrome Phase III; RYSTIGGO ocular myasthenia gravis Phase III to start; galvokimig entering COPD and bronchiectasis programs.
Strategic Manufacturing Investment
Announced a major U.S. investment of $5 billion (direct and indirect) to build a mammalian manufacturing site to produce BIMZELX, strengthening supply and U.S. footprint.
Partner Contributions and Other Franchise Strength
EVENITY partner net contribution EUR 632 million (up 32%); RYSTIGGO + ZILBRYSQ generated incremental net sales >EUR 270 million; FINTEPLA grew 26% YoY to EUR 427 million and >14,000 patients treated; CIMZIA volumes grew 4% despite pricing pressures.
2026 Guidance & Margin Upside
2026 guidance: revenues expected to grow high single-digit to low double-digit at constant FX; adjusted EBITDA expected to grow high single-digit to high-teens (and on an adjusted EUR 2.4B base, high-teens to high-20s), driven by portfolio mix and margin expansion.
ESG Recognition
Improved CDP climate change rating to A and ranked #2 Industry Leader in Global Biotech by Sustainalytics.