Efficacy Durability RiskAn initial complete response signal might not translate into long lasting benefit, and lack of durable responses could significantly limit upside for the program.
Financial Runway And Reliance On ReadoutsContinued operating losses increase dependence on positive clinical results to justify valuation, creating downside risk if upcoming readouts fail to meet expectations.
Safety And Tolerability ConcernsPrior therapies in this class exhibited significant tolerability issues, including frequent dose reductions and disruptive side effects, which raises the risk that safety problems could impede approval or commercial adoption.