Spyre Therapeutics, Inc (SYRE)
NASDAQ:SYRE
SYRE Analyst Ratings
Strong Buy
13 Buy
0 Hold
0 Sell
TipRanks enables you to focus on the analyst rating consensus of all analysts or only the top performers in the past 3 months
SYRE Stock 12 Month Forecast
Average Price Target
$78.67
▲(53.38% Upside)
| Highest Price Target$107.00 | Average Price Target$78.67 | Lowest Price Target$50.00 |
The highest, average, and lowest price target of all analysts. Click on ‘Top Analysts’ to focus on the best performers.
Detailed List of Analyst Forecasts
Detailed List of Analyst Forecasts
Leerink Partners
$49→$106
Buy
106.67%
Upside
Reiterated
04/13/26
LifeSci Capital
$64→$107
Buy
108.62%
Upside
Assigned
04/13/26
BTIG
$70→$98
Buy
91.07%
Upside
Reiterated
04/13/26
TD Cowen
―
Buy
―
Reiterated
04/13/26
JonesTrading
$64
Buy
24.78%
Upside
Reiterated
04/13/26
Wedbush
$80
Buy
55.98%
Upside
Reiterated
04/13/26
Jefferies
$47→$85
Buy
65.72%
Upside
Reiterated
04/13/26
Raymond James
$80
Buy
55.98%
Upside
Initiated
04/10/26
Stifel Nicolaus
$70→$92
Buy
79.37%
Upside
Reiterated
03/22/26
Wells Fargo
$50
Buy
-2.52%
Downside
Reiterated
03/17/26
Mizuho Securities
$53
Buy
3.33%
Upside
Reiterated
02/20/26
Citi
$64
Buy
24.78%
Upside
Reiterated
02/20/26
Deutsche Bank
$43
Buy
-16.16%
Downside
Initiated
09/26/25
Evercore ISI
―
Buy
―
Reiterated
06/18/25
Analyst Type
Any
Ranks
Any
Analyst Rating
Any
Upside/ Downside
Any
Action
Any
Leerink Partners
$49→$106
Buy
106.67%
Upside
Reiterated
04/13/26
LifeSci Capital
$64→$107
Buy
108.62%
Upside
Assigned
04/13/26
BTIG
$70→$98
Buy
91.07%
Upside
Reiterated
04/13/26
TD Cowen
―
Buy
―
Reiterated
04/13/26
JonesTrading
$64
Buy
24.78%
Upside
Reiterated
04/13/26
Wedbush
$80
Buy
55.98%
Upside
Reiterated
04/13/26
Jefferies
$47→$85
Buy
65.72%
Upside
Reiterated
04/13/26
Raymond James
$80
Buy
55.98%
Upside
Initiated
04/10/26
Stifel Nicolaus
$70→$92
Buy
79.37%
Upside
Reiterated
03/22/26
Wells Fargo
$50
Buy
-2.52%
Downside
Reiterated
03/17/26
Mizuho Securities
$53
Buy
3.33%
Upside
Reiterated
02/20/26
Citi
$64
Buy
24.78%
Upside
Reiterated
02/20/26
Deutsche Bank
$43
Buy
-16.16%
Downside
Initiated
09/26/25
Evercore ISI
―
Buy
―
Reiterated
06/18/25
Best Analysts Covering Spyre Therapeutics
3 Months
xxx
Success Rate
8/12 ratings generated profit
Average Return
+24.03%
Copying xxxxxxxxxxxxxxxxxx
trades and holding each position for 3 Months would result in 66.67% of your transactions generating a profit, with an average return of +24.03% per trade.
1 Year
Success Rate
10/12 ratings generated profit
Average Return
+80.53%
Copying Alex Thompson CFA's trades and holding each position for 1 Year would result in 83.33% of your transactions generating a profit, with an average return of +80.53% per trade.
2 Years
xxx
Success Rate
12/12 ratings generated profit
Average Return
+120.38%
Copying xxxxxxxxxxxxxxxxxx
trades and holding each position for 2 Years would result in 100.00% of your transactions generating a profit, with an average return of +120.38% per trade.
The Best Analyst Covering tool allows you to follow the analysts who have the best success rates and average returns on a specific stock. Only analysts that gave a Buy or Sell rating on the stock in the past 12 months are eligible for inclusion in this tool. Follow the analysts of your choice to receive real-time updates when they publish a new rating.
SYRE Analyst Recommendation Trends
Rating
Dec 25
Jan 26
Feb 26
Mar 26
Apr 26
Strong Buy
7
11
11
11
13
Buy
2
3
7
10
12
Hold
0
0
0
0
0
Sell
0
0
0
0
0
Strong Sell
0
0
0
0
0
total
9
14
18
21
25
Each month's total comprises the sum of three months' worth of ratings.
SYRE Financial Forecast
SYRE Stock Forecast FAQ
What is SYRE’s average 12-month price target, according to analysts?
Based on analyst ratings, Spyre Therapeutics, Inc’s 12-month average price target is 78.67.
What is SYRE’s upside potential, based on the analysts’ average price target?
Spyre Therapeutics, Inc has 53.38% upside potential, based on the analysts’ average price target.
Can I see which stocks the top-ranking analysts are rating?
Yes, go to the Analysts’ Top Stocks tool to see stocks with a Strong Buy or Strong Sell analyst rating consensus, according to the top performers.
How can I follow the stock ratings of top Wall Street analysts?
Head over to our Expert Center to see a list of the top 100 Wall Street analysts and follow the analysts of your choice. Visit their profiles for more details about their stock ratings and see how they perform on a stock-by-stock basis.
Is SYRE a Buy, Sell or Hold?
Spyre Therapeutics, Inc has a consensus rating of Strong Buy which is based on 13 buy ratings, 0 hold ratings and 0 sell ratings.
What is Spyre Therapeutics, Inc’s price target?
The average price target for Spyre Therapeutics, Inc is 78.67. This is based on 13 Wall Streets Analysts 12-month price targets, issued in the past 3 months.
The highest analyst price target is $107.00 ,the lowest forecast is $50.00. The average price target represents 53.38% Increase from the current price of $51.29.
The highest analyst price target is $107.00 ,the lowest forecast is $50.00. The average price target represents 53.38% Increase from the current price of $51.29.
What do analysts say about Spyre Therapeutics, Inc?
Spyre Therapeutics, Inc’s analyst rating consensus is a Strong Buy. This is based on the ratings of 13 Wall Streets Analysts.
How can I buy shares of SYRE?
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