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Spyre Therapeutics (SYRE)
NASDAQ:SYRE
US Market
SYRE
Spyre Therapeutics
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Spyre Therapeutics (SYRE) Ratios

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Spyre Therapeutics Ratios

SYRE's free cash flow for Q1 2026 was $0.00. For the 2026 fiscal year, SYRE's free cash flow was decreased by $ and operating cash flow was $0.00. See a summary of the company’s cash flow.
Ratios
TTM
Dec 25Dec 24Dec 23Dec 22
Liquidity Ratios
Current Ratio
 8.97 13.25 11.26 10.68 4.25
Quick Ratio
 8.97 13.25 11.26 10.68 4.25
Cash Ratio
 1.14 1.46 1.65 5.91 2.38
Solvency Ratio
 -1.93 -2.32 -2.29 -2.14 -3.93
Operating Cash Flow Ratio
 -2.18 -2.88 -2.91 -3.12 -5.47
Short-Term Operating Cash Flow Coverage
 0.00 0.00 0.00 0.00 0.00
Net Current Asset Value
$ 670.81M$ 715.24M$ 517.79M$ 183.69M$ 41.42M
Leverage Ratios
Debt-to-Assets Ratio
 0.00 0.00 0.00 0.00 0.07
Debt-to-Equity Ratio
 0.00 0.00 0.00 0.00 0.09
Debt-to-Capital Ratio
 0.00 0.00 0.00 0.00 0.08
Long-Term Debt-to-Capital Ratio
 0.00 0.00 0.00 0.00 0.00
Financial Leverage Ratio
 1.14 1.09 1.18 1.86 1.41
Debt Service Coverage Ratio
 0.00 0.00 0.00 0.00 0.00
Interest Coverage Ratio
 0.00 0.00 0.00 0.00 0.00
Debt to Market Cap
 0.00 0.00 0.00 0.00 0.00
Interest Debt Per Share
 0.00 0.00 0.00 0.00 1.37
Net Debt to EBITDA
 0.57 0.41 0.43 1.48 0.37
Profitability Margins
Gross Profit Margin
0.00%0.00%0.00%100.00%100.00%
EBIT Margin
-222.43%0.00%0.00%-14510.61%-3640.23%
EBITDA Margin
-189.28%0.00%0.00%-14401.81%-3555.90%
Operating Profit Margin
-255.97%0.00%0.00%-27347.97%-3640.23%
Pretax Profit Margin
-198.28%0.00%0.00%-38241.08%-3604.59%
Net Profit Margin
-198.28%0.00%0.00%-38238.15%-3598.75%
Continuous Operations Profit Margin
-198.28%0.00%0.00%-38238.15%-3598.75%
Net Income Per EBT
100.00%99.99%100.02%99.99%99.84%
EBT Per EBIT
77.46%74.07%99.71%139.83%99.02%
Return on Assets (ROA)
-23.49%-19.95%-34.19%-99.10%-117.81%
Return on Equity (ROE)
-31.25%-21.70%-40.17%-184.11%-166.61%
Return on Capital Employed (ROCE)
-34.12%-29.14%-37.62%-78.19%-150.09%
Return on Invested Capital (ROIC)
-34.12%-29.14%-37.62%-78.19%-148.20%
Return on Tangible Assets
-23.49%-19.95%-34.19%-99.10%-117.81%
Earnings Yield
-0.69%-1.37%-19.00%-228.26%-220.99%
Efficiency Ratios
Receivables Turnover
 19.67 0.00 0.00 0.00 6.21
Payables Turnover
 15.90 19.28 0.00 0.00 0.00
Inventory Turnover
 0.00 0.00 0.00 0.00 0.00
Fixed Asset Turnover
 0.00 0.00 0.00 0.00 0.35
Asset Turnover
 0.12 0.00 0.00 <0.01 0.03
Working Capital Turnover Ratio
 0.13 0.00 0.00 <0.01 0.04
Cash Conversion Cycle
 -4.40 -18.93 0.00 0.00 58.77
Days of Sales Outstanding
 18.55 0.00 0.00 0.00 58.77
Days of Inventory Outstanding
 0.00 0.00 0.00 0.00 0.00
Days of Payables Outstanding
 22.96 18.93 0.00 0.00 0.00
Operating Cycle
 18.55 0.00 0.00 0.00 58.77
Cash Flow Ratios
Operating Cash Flow Per Share
 -0.54 -0.49 -3.35 -14.49 -23.77
Free Cash Flow Per Share
 -0.54 -0.49 -3.35 -14.49 -23.78
CapEx Per Share
 0.00 0.00 0.00 0.00 0.01
Free Cash Flow to Operating Cash Flow
 1.00 1.00 1.00 1.00 1.00
Dividend Paid and CapEx Coverage Ratio
 0.00 0.00 0.00 0.00 -2.11K
Capital Expenditure Coverage Ratio
 0.00 0.00 0.00 0.00 -2.11K
Operating Cash Flow Coverage Ratio
 0.00 0.00 0.00 0.00 -17.31
Operating Cash Flow to Sales Ratio
 -2.05 0.00 0.00 -112.77 -34.41
Free Cash Flow Yield
-4.10%-1.49%-14.38%-67.31%-211.42%
Valuation Ratios
Price-to-Earnings (P/E) Ratio
 -144.73 -73.04 -5.26 -0.44 -0.45
Price-to-Sales (P/S) Ratio
 50.09 0.00 0.00 167.52 16.28
Price-to-Book (P/B) Ratio
 38.71 15.85 2.11 0.81 0.75
Price-to-Free Cash Flow (P/FCF) Ratio
 -24.40 -66.98 -6.96 -1.49 -0.47
Price-to-Operating Cash Flow Ratio
 -139.77 -66.98 -6.96 -1.49 -0.47
Price-to-Earnings Growth (PEG) Ratio
 2.86 1.94 0.06 >-0.01 0.71
Price-to-Fair Value
 38.71 15.85 2.11 0.81 0.75
Enterprise Value Multiple
 -25.90 -53.69 -4.83 0.32 -0.09
Enterprise Value
 4.44B 11.25B 1.01B -40.47M 7.69M
EV to EBITDA
 -25.90 -53.69 -4.83 0.32 -0.09
EV to Sales
 49.02 0.00 0.00 -45.68 3.30
EV to Free Cash Flow
 -23.87 -66.47 -6.39 0.41 -0.10
EV to Operating Cash Flow
 -23.87 -66.47 -6.39 0.41 -0.10
Tangible Book Value Per Share
 1.94 2.07 11.01 26.68 14.92
Shareholders’ Equity Per Share
 1.94 2.07 11.01 26.68 14.92
Tax and Other Ratios
Effective Tax Rate
 0.00 <0.01 >-0.01 <0.01 <0.01
Revenue Per Share
 0.26 0.00 0.00 0.13 0.69
Net Income Per Share
 -0.52 -0.45 -4.42 -49.12 -24.86
Tax Burden
 1.00 1.00 1.00 1.00 1.00
Interest Burden
 0.89 0.71 1.00 2.64 0.99
Research & Development to Revenue
 2.10 0.00 0.00 101.02 25.15
SG&A to Revenue
 0.57 0.00 0.00 45.09 12.25
Stock-Based Compensation to Revenue
 0.32 0.00 0.00 28.98 3.05
Income Quality
 1.86 1.09 0.76 0.29 0.96
Currency in USD