Strong full-year revenue growth
Total revenues for FY2025 were $2.2 billion, up 16% year-over-year, including $1.86 billion in net product revenue (PMOs $966M; ELEVIDYS $899M) showing continued commercial traction.
Solid cash position and positive core cash generation
Ended 2025 with $954 million in cash and investments (up $89M in Q4); base business (ex-Arrowhead payments) generated more than $330 million of positive cash flow in 2025 and management expects to be cash-flow positive and non-GAAP profitable in 2026 under reasonable scenarios.
ELEVIDYS durable, disease-modifying data (EMBARK 3-year)
Three-year EMBARK Part 1 results show durable, statistically significant efficacy vs external control: 73% slowing in disease progression for time-to-rise, 70% for 10m walk/run, NSAA +4.39 point difference at year 3 (p=0.0002); no new safety signals reported through three years.
PMO franchise stability and compliance
PMO net product revenue totaled $966 million in 2025; Q4 PMO revenue $259 million (EXONDYS $148M, VYONDYS $34M, AMONDYS $77M) with year-after-year compliance rates consistently over 90%.
Pipeline advancement: multiple clinical-stage siRNA programs
Five clinical-stage siRNA programs advancing (DM1 SRP-1003, FSHD, IPF, SCA2, Huntington's SRP-1005 initiated), with additional preclinical programs (SCA1, SCA3) and planned readouts (preliminary DM1/FSHD data end of quarter; further PD/splice data later in 2026).
Regulatory and commercial milestones
ELEVIDYS received traditional approval for ambulatory patients and approval to run a sirolimus pretreatment study for non-ambulatory patients; meeting with FDA scheduled to discuss transitioning AMONDYS and VYONDYS to traditional approval following ESSENCE confirmatory data.
2026 revenue and collaboration visibility
Provided net product revenue guidance for 2026 of $1.2B–$1.4B (management advises modeling toward the low end given timing uncertainty) and expects collaboration, contract manufacturing, and royalty revenues of $450M–$550M in 2026 (including a $40M Roche milestone and ~$325M noncash collaboration revenue).