Sarepta Therapeutics: Undervalued Stock with Strong US Market Potential Despite EMA HoldWe also know that this patient was on the older side (16-years old) and likely heavier (versus younger patients), which requires a higher dose. As we previously outlined (here), we acknowledge that such severe side effects associated with mortality can certainly be alarming and cause the community to question the risk/benefit of treating older patients. However, we believe that the very low overall incidence, which we estimate at <0.125% based on aggregate exposure to date, is encouraging (>800 patients dosed in clinical trials or as a prescribed therapy). Approvability in the EU has long been a question and as such, we continue to assume a 60% probability-of-success/PoS in the EU and RoW. Moreover, considering the partnership with Roche, ex- US sales are not a major value driver for our model, nor are they a core focus for investors.