Adverse EventsGrade 3+ adverse events occurred in 58% of patients, notably including anemia, neutrophil count decrease, rash, fatigue, and diarrhea.
Competitive LandscapeCompetitor's data showed an objective response rate slightly exceeding zoldonrasib’s in small patient numbers, limiting the comparison.
Development Path ChallengesRMC-5127 may not follow the same registration path in PDAC due to being early in development and the likely broad penetration of daraxonrasib.