Clinical RisksRisks include commercial risk with respect to Cabometyx (cabozantinib) and failure to generate favorable data from ongoing clinical programs, particularly those involving zanzalintinib.
Sales ImpactInventory for the quarter decreased roughly 9%, to 2.0 weeks on hand, which corresponds to a negative impact of roughly $8 million on Cabometyx sales.
Toxicity ConcernsExelixis’s triplet did not yield a supportive risk/benefit profile, driven by toxicity concerns from the Phase III COSMIC-313 study.