Strong topline and cabozantinib franchise revenue growth
Total revenue of approximately $611 million in Q1 2026; U.S. cabo franchise net product revenues grew 8% year-over-year to $555 million; global cabo franchise net product revenues grew 12.5% year-over-year to $764 million. CABOMETYX net product revenues were $552.8 million (including $3.6 million in clinical trial sales).
Solid profitability and liquidity position
GAAP net income of ~$210.5 million (EPS $0.81 basic / $0.79 diluted) and non-GAAP net income of ~$232.8 million (EPS $0.90 basic / $0.87 diluted), excluding ~$22.3 million stock‑based compensation (net of tax). Cash and marketable securities of ~ $1.4 billion at 03/31/2026.
Commercial momentum and market share gains
CABOMETYX TRx volume grew 14% in Q1 2026 vs Q1 2025 while the oral TKI market basket grew 7% in the same period; CABOMETYX market share increased three percentage points from 44% to 47% (2025 to Q1 2026). Q1 had the highest number of new patient starts ever for CABOMETYX and the highest quarterly first-line RCC market share to date for CABOMETYX + nivolumab.
Aggressive capital return via share repurchases
Repurchased approximately $430.8 million of common stock in Q1 2026, retiring ~10 million shares at an average price of $42.99. $159.4 million remained under the prior $750 million repurchase plan and an additional $50 million buyback authorization was approved in May 2026.
ZANZA regulatory progress and broad pivotal program
NDA under review for ZANZA + atezolizumab in third-line-plus colorectal cancer (STELLAR-303); STELLAR-303 met one dual primary endpoint demonstrating a 20% reduction in risk of death in the ITT population. PDUFA date set for early December 2026. The ZANZA program includes seven ongoing or soon-to-start pivotal trials and multiple additional Phase II/III studies across CRC, RCC (including STELLAR-304 in non–clear cell RCC), NETs (STELLAR-311), meningioma (STELLAR-201 initiated), and other indications (STELLAR-316 adjuvant MRD trial planned midyear).
Clinical development momentum and enrollment
STELLAR-311 (ZANZA vs everolimus in NET) enrollment is pacing well and is ahead of initial projections; STELLAR-304 enrollment completed and top-line results expected in 2026 (second half). STELLAR-316 (MRD-positive resected stage 2/3 CRC) is on track to start around midyear, targeting a high‑risk ~20% MRD‑positive population.
Early-stage pipeline advancement
Four early clinical molecules (XL309, XB010, XB628, XB371) progressing in Phase 1, plus additional discovery-stage small molecule and ADC programs (including DLL3-targeted ADC XB773) being advanced to identify next franchise opportunities beyond cabo and ZANZA.
Operating expense control with modest sequential improvement
Total operating expenses of approximately $359 million in Q1 2026 versus $363 million in Q1 2025, reflecting lower clinical trial costs partially offset by higher FTE-related costs and stock-based compensation.