Strong Financial Performance
Exelixis reported total revenues of approximately $598 million for the third quarter of 2025, with cabozantinib franchise net product revenues of approximately $543 million, marking a 14% year-over-year increase.
Successful Launch and Growth in Neuroendocrine Tumors
CABOMETYX has rapidly become the market leader in second-line plus neuroendocrine tumors with greater than 40% new patient share for oral therapies.
Zanzalintinib Clinical Success
Positive results for STELLAR-303 in colorectal cancer (CRC) with a 20% reduction in the risk of death in the ITT population, marking the first clinical success in a non-MSI-high third-line plus CRC population.
Share Repurchase Program
Exelixis repurchased approximately $99 million of the company's shares in the third quarter, with an additional $750 million share repurchase program authorized.